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公开(公告)号：US10751555B2
公开(公告)日：2020-08-25
申请号：US16533761
申请日：2019-08-06
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.
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公开(公告)号：US10112060B2
公开(公告)日：2018-10-30
申请号：US15847772
申请日：2017-12-19
申请人： W. Davis Lee , Mark R. Amato , James P. Bennett
发明人： W. Davis Lee , Mark R. Amato , James P. Bennett
摘要： The invention comprises an apparatus and method of use thereof for extracting ions from an ion source, such as for use in cancer treatment or tomographic imaging. The extraction apparatus uses a triode extraction system, with the ion source and/or first electrode held at a first potential; an extraction electrode held at a second potential; and a gating electrode, positioned between the ion source and the extraction electrode, oscillating and/or alternating between a first suppression potential proximate that of the ion source potential and a second extraction potential between the ion source potential and the extraction electrode potential. Optionally, the ion source comprises an electron cyclotron resonance ion source.
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公开(公告)号：US20180200538A1
公开(公告)日：2018-07-19
申请号：US15919067
申请日：2018-03-12
申请人： James P. Bennett , W. Davis Lee , Mark R. Amato
发明人： James P. Bennett , W. Davis Lee , Mark R. Amato
CPC分类号： A61N5/1077 , A61B6/00 , A61B6/03 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/087 , G21K1/093 , G21K5/04 , G21K5/10 , H01J35/14
摘要： The invention comprises a method and apparatus for treating a tumor of a patient with charged particles, comprising the step of developing a multi-modality treatment plan, the multi-modality treatment plan directing: (1) use of a first beam type to treat a first volume of the tumor, the first beam type a first mass per particle and (2) use of a second beam type to treat a second volume of the tumor, the second beam type comprising a second mass per particle, where the second mass per particle is at least ten percent different than the first mass per particle and the second volume differs from the first volume. The multi-modality treatment plan is optionally formed by selectively merging treatment plans using the respective particle types or is developed using properties of the multiple particle types.
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公开(公告)号：US20170150933A1
公开(公告)日：2017-06-01
申请号：US15430008
申请日：2017-02-10
申请人： James P. Bennett , W. Davis Lee
发明人： James P. Bennett , W. Davis Lee
CPC分类号： A61B6/4258 , A61B6/032 , A61B6/037 , A61B6/12 , A61B6/4014 , A61B6/4085 , A61B6/4216 , A61B6/4266 , A61B6/4417 , A61B6/482 , A61B6/485 , A61B6/487 , A61B6/5205 , A61B6/5211 , A61B6/582 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a multiplexed proton tomography imaging apparatus and method of use thereof. In one embodiment, a method for imaging a tumor of a patient comprises the steps of: (1) simultaneously detecting spatially resolved positively charged particle positions passing through each of a set of cross-section planes, where the cross-section planes are both prior to and posterior to the patient along a path of the positively charged particles; (2) determining a prior vector for each of the individual positively charged particles entering a patient using the detected positions; (3) determining a posterior vector for each of the individual positively charged particles exiting the patient using the detected positions; (4) generating a probable path of each positively charged particle through the patient; and (5) generating an image of the patient using the n probable proton paths and optionally a detected residual energy of each proton.
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公开(公告)号：US12042672B2
公开(公告)日：2024-07-23
申请号：US17391886
申请日：2021-08-02
IPC分类号： A61N5/10
CPC分类号： A61N5/1078 , A61N5/1049 , A61N2005/1087
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.
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公开(公告)号：US20210393988A1
公开(公告)日：2021-12-23
申请号：US17391886
申请日：2021-08-02
IPC分类号： A61N5/10
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.
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67.发明授权公开(公告)号：US11185717B2
公开(公告)日：2021-11-30
申请号：US16434123
申请日：2019-06-06
申请人： Jillian Reno , Armin Huseinovic , Mark R. Amato , Daniel J. Raymond , W. Davis Lee , Lou Wainwright , James P. Bennett
发明人： Jillian Reno , Armin Huseinovic , Mark R. Amato , Daniel J. Raymond , W. Davis Lee , Lou Wainwright , James P. Bennett
摘要： The invention comprises a segmented rolling floor apparatus and method of use thereof, such as for use in a charged particle cancer therapy system. The segmented rolling floor comprises a first spool and a second spool, attached to opposite ends of the rolling floor, which cooperatively wind and unwind the rolling floor. The segmented rolling floor circumferentially surrounds a nozzle system penetrating through an aperture in the segmented rolling floor, where the nozzle system is used to deliver charged particles, from an accelerator, to a tumor of a patient. The rolling floor and nozzle systems move at respective rates maintaining the nozzle system in the aperture allowing for a safe/walkable floor while allowing treatment of the tumor as a gantry rotates the nozzle system and delivers protons to the tumor from positions above and below the floor.
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公开(公告)号：US10555710B2
公开(公告)日：2020-02-11
申请号：US15430208
申请日：2017-02-10
申请人： James P. Bennett , W. Davis Lee
发明人： James P. Bennett , W. Davis Lee
摘要： The invention comprises a method and apparatus for imaging a tumor with X-rays while, simultaneously or alternatingly, treating or imaging the tumor with positively charged particles. An X-ray imaging system, such as one or two sets of a cone beam X-ray source coupled to an X-ray detector, is rotatable about a first axis and a patient. The X-ray imaging system is positioned off axis a path of charged particles delivered through an exit port of a nozzle system from a synchrotron and does not block a path of the positively charged particles from the exit nozzle to the patient or an imaging path from the patient to a scintillation detector. Fiducial indicators are used to confirm an unobstructed path of the positively charged particles in a treatment room comprising many movable elements, such as the X-ray imaging system and a patient positioning system/couch.
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公开(公告)号：US10029124B2
公开(公告)日：2018-07-24
申请号：US15432724
申请日：2017-02-14
申请人： W. Davis Lee , Jillian Reno , James P. Bennett
发明人： W. Davis Lee , Jillian Reno , James P. Bennett
摘要： The invention comprises a method and apparatus for treating a tumor with protons using multiple beamline positions not having an isocenter, including the steps of: (1) delivering the protons from a synchrotron along a redirectable beam transport path to yield a plurality of incident vectors, each of the plurality of incident vectors directed toward the treatment room and (2) redirecting the protons traveling along each of the plurality of incident vectors, with an output nozzle, to the tumor, where a first vector, of the plurality of incident vectors, comprises a first direction intersecting the tumor and where a second vector, of the plurality of incident vectors, comprises a second direction passing by the tumor without entering the tumor. The step of redirecting directs the protons traveling along the first and second incident vectors, respectively, to a first and second path intersecting a front and the back of the tumor.
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70.发明申请公开(公告)号：US20170216632A1
公开(公告)日：2017-08-03
申请号：US15489396
申请日：2017-04-17
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61B6/032 , A61B6/037 , A61B6/4258 , A61B6/5205 , A61N5/103 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/093 , G21K5/04
摘要： The invention comprises a method and apparatus for directing a positively charged particle beam to a tumor of a patient, comprising the steps of: (1) transporting the positively charged particle beam sequentially from a synchrotron, through a beam transport line, and through a nozzle system toward the tumor, the beam transport line comprising a rotatable beamline section; (2) pre-rotating the positively charged particle beam using a solenoid, the solenoid positioned in the beam transport line between the synchrotron and the rotatable beamline section; and (3) rotating the rotatable beamline section, where the step of pre-rotating maintains a geometric relationship between a radial cross-section of the positively charged particle beam and magnet surfaces in the rotatable beamline section as a function of rotation of the rotatable beamline section, which reduces otherwise changed dispersive forces as the rotatable beamline is positioned in separate areas about the patient.
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