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公开(公告)号：US11827881B2
公开(公告)日：2023-11-28
申请号：US18066223
申请日：2022-12-14
IPC分类号： C12N15/11 , A61K31/7105 , C12N9/12 , C12N9/22 , C12N15/10 , C12N15/85 , C12N15/113 , C12N15/90
CPC分类号： C12N15/111 , A61K31/7105 , C12N9/1276 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/85 , C12N15/907 , C12N2310/20 , C12N2310/3519 , C12Y207/07049
摘要： This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
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公开(公告)号：US20230135673A1
公开(公告)日：2023-05-04
申请号：US18066233
申请日：2022-12-14
IPC分类号： C12N15/11 , A61K31/7105 , C12N9/12 , C12N9/22 , C12N15/10 , C12N15/85 , C12N15/113 , C12N15/90
摘要： This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
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公开(公告)号：US20220154224A1
公开(公告)日：2022-05-19
申请号：US17649308
申请日：2022-01-28
IPC分类号： C12N15/90 , C12N9/22 , C12N15/113 , C12N15/10 , C12N9/12
摘要： This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
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公开(公告)号：US20220145293A1
公开(公告)日：2022-05-12
申请号：US17451734
申请日：2021-10-21
摘要： This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
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公开(公告)号：US20240229023A9
公开(公告)日：2024-07-11
申请号：US18234690
申请日：2023-08-16
发明人： Omar Abudayyeh , Jonathan Gootenberg , Hiroshi Nishimasu , Kazuki Kato , Cian Schmitt-Ulms , Kaiyi Jiang
CPC分类号： C12N15/111 , C12N9/22 , C12N9/50 , C12N15/102 , C12N15/11 , C12Y304/22 , C07K2319/33 , C07K2319/50 , C07K2319/60 , C07K2319/61 , C12N2310/20
摘要： Disclosed are methods of RNA-triggered protein cleavage by the CRISPR Cas7-11-Csx29 complex. A guide RNA specifically hybridizes to a RNA target, and Csx29 cleaves Csx30 when Cas7-11:Csx29 complex binds to the target RNA.
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公开(公告)号：US20240132883A1
公开(公告)日：2024-04-25
申请号：US18234690
申请日：2023-08-15
发明人： Omar Abudayyeh , Jonathan Gootenberg , Hiroshi Nishimasu , Kazuki Kato , Cian Schmitt-Ulms , Kaiyi Jiang
CPC分类号： C12N15/111 , C12N9/22 , C12N9/50 , C12N15/102 , C12N15/11 , C12Y304/22 , C07K2319/33 , C07K2319/50 , C07K2319/60 , C07K2319/61 , C12N2310/20
摘要： Disclosed are methods of RNA-triggered protein cleavage by the CRISPR Cas7-11-Csx29 complex. A guide RNA specifically hybridizes to a RNA target, and Csx29 cleaves Csx30 when Cas7-11:Csx29 complex binds to the target RNA.
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公开(公告)号：US11952571B2
公开(公告)日：2024-04-09
申请号：US18487744
申请日：2023-10-16
IPC分类号： C12N15/85 , A61K31/7105 , C12N9/12 , C12N9/22 , C12N15/10 , C12N15/11 , C12N15/113 , C12N15/90
CPC分类号： C12N15/111 , A61K31/7105 , C12N9/1276 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/85 , C12N15/907 , C12N2310/20 , C12N2310/3519 , C12Y207/07049
摘要： This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.
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公开(公告)号：US20230383274A1
公开(公告)日：2023-11-30
申请号：US18303533
申请日：2023-04-19
发明人： Omar Abudayyeh , Jonathan Gootenberg , Kaiyi Jiang
CPC分类号： C12N9/22 , C12N15/63 , C12N15/102
摘要： Provided herein are compositions comprising, inter alia, a ttRNAs comprising (i) a primer binding site, (ii) a reverse transcriptase template sequence, (iii) an aptamer, and (iv) an integration sequence comprising an integration site. Also described herein are method of use of the ttRNAs in methods of editing and integrating polynucleotide sequences.
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公开(公告)号：US20220073891A1
公开(公告)日：2022-03-10
申请号：US17365777
申请日：2021-07-01
摘要： This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.
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公开(公告)号：US20240294890A1
公开(公告)日：2024-09-05
申请号：US18649077
申请日：2024-04-29
IPC分类号： C12N9/22 , A61K38/00 , A61K48/00 , C12N9/78 , C12N15/10 , C12N15/11 , C12N15/63 , C12Q1/6825
CPC分类号： C12N9/22 , A61K48/005 , C12N9/78 , C12N15/102 , C12N15/11 , C12N15/63 , C12Y305/04004 , C12Y305/04005 , A61K38/00 , C07K2319/85 , C12N2310/20 , C12N2320/10 , C12N2320/33 , C12Q1/6825
摘要： This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.
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