METHODS AND REAGENTS FOR ACTIVATING HEAT SHOCK PROTEIN 70
    62.
    发明申请
    METHODS AND REAGENTS FOR ACTIVATING HEAT SHOCK PROTEIN 70 审中-公开
    激活热休克蛋白的方法和试剂70

    公开(公告)号:US20070259820A1

    公开(公告)日:2007-11-08

    申请号:US11743439

    申请日:2007-05-02

    IPC分类号: A61K38/05 C07K5/08

    CPC分类号: C07D239/36

    摘要: The present disclosure is directed to new compounds useful as modulators of Heat Shock Proteins (HSP). In particular, the present disclosure provides new small molecule peptide-derived compounds having HSP modulation activity, especially Hsp70 modulation activity, and methods of preventing or ameliorating beta-amyloid or polyglutamine aggregation, decreasing cell proliferation, or increasing chaperon activity of the HSPs.

    摘要翻译: 本公开涉及可用作热休克蛋白(HSP)的调节剂的新化合物。 特别地,本公开提供了具有HSP调节活性,特别是Hsp70调节活性的新型小分子肽衍生化合物,以及预防或改善β-淀粉样蛋白或聚谷氨酰胺聚集,降低细胞增殖或增加HSP的伴侣活性的方法。

    Application programming interface for changing the visual style
    63.
    发明授权
    Application programming interface for changing the visual style 有权
    应用程序编程界面,用于改变视觉风格

    公开(公告)号:US07190369B2

    公开(公告)日:2007-03-13

    申请号:US11083177

    申请日:2005-03-15

    IPC分类号: G09G5/00 G06T1/00 G06F5/02

    CPC分类号: G06F9/451

    摘要: A method of communicating between a graphical component library and an appearance manager is provided that includes issuing a request, that includes component defining parameters, for rendering services by a graphical component library. The appearance manager receives the request for rendering services and assigns appearance characteristics to the graphical component based upon the provided parameters. A method of rendering graphical components on the display of a computer system is also provided that includes rendering the requested graphical component according to the appearance characteristics assigned by the appearance manager. A method is also provided for communicating between a graphical component library and an appearance manager that includes issuing a request that includes component defining parameters, for information about the defined component. The appearance manager receives the request for information and provides the requested information to the graphical component library based upon the provided parameters.

    摘要翻译: 提供了一种在图形组件库和外观管理器之间进行通信的方法,其包括发出包括用于通过图形组件库呈现服务的定义参数的组件的请求。 外观管理器接收呈现服务的请求,并根据提供的参数为图形组件分配外观特征。 还提供了在计算机系统的显示器上呈现图形组件的方法,其包括根据由外观管理器分配的外观特征呈现所请求的图形组件。 还提供了一种用于在图形组件库和外观管理器之间进行通信的方法,所述图形组件库和外观管理器包括发布包括组件定义参数的请求,用于关于所定义的组件的信息。 外观管理器接收信息请求,并根据提供的参数将所请求的信息提供给图形组件库。

    Moisture retention seal
    64.
    发明申请
    Moisture retention seal 有权
    保湿密封

    公开(公告)号:US20070045315A1

    公开(公告)日:2007-03-01

    申请号:US11212111

    申请日:2005-08-25

    IPC分类号: B65D51/18 B65D39/00 B65D43/04

    摘要: Provided is a moisture retention seal for use with a package. The moisture retention seal includes an opened-ended canister having a plurality of canister sealing surfaces. Snap-fitted with spatial interference to the canister at its opened-end, is a moisture retention closure having a plurality of closure sealing surfaces. Each canister sealing surface cooperates with a corresponding one of the closure sealing surfaces to form a plurality of partial seals. At least one of the partial seals includes a micro-bead surface comprising one or more small, inwardly directed, narrowly spaced-apart, micro-bead elements. The package that includes a moisture retention seal of the present invention employs only molded parts and does not require gaskets or secondary seals.

    摘要翻译: 提供了用于包装的保湿密封件。 保湿密封件包括具有多个罐密封表面的开口的罐。 具有在其开口端处对罐进行空间干涉的紧配合是具有多个封闭密封表面的保湿封闭件。 每个罐密封表面与相应的一个闭合密封表面配合以形成多个局部密封。 部分密封件中的至少一个包括微珠表面,微珠表面包括一个或多个小的,向内的,狭窄间隔的微珠元件。 包括本发明的保湿密封件的包装件仅使用模制​​部件,并且不需要垫圈或二次密封。

    Method and apparatus for tilt corrected lateral shear in a lateral shear plus rotational shear absolute flat test
    65.
    发明申请
    Method and apparatus for tilt corrected lateral shear in a lateral shear plus rotational shear absolute flat test 有权
    用于横向剪切加旋转剪切绝对平面测试中的倾斜校正侧向剪切的方法和装置

    公开(公告)号:US20060285123A1

    公开(公告)日:2006-12-21

    申请号:US11453677

    申请日:2006-06-15

    IPC分类号: G01B11/02

    CPC分类号: G01B11/2441

    摘要: A Fizeau or other interferometer is used to provide high resolution, in-situ calibration of an external angle measurement system such as widely spaced high stability plane mirror interferometers (HSPMIs)). The calibrated measurement system then measures mechanical tilt during shearing. The tilt data is used to correct the sheared data, preferably before computation of the rotationally invariant (RI) terms. Altematively, the data may be used to compute the spurious quadratic term and correct after integration.

    摘要翻译: Fizeau或其他干涉仪用于提供外部角度测量系统(例如间隔高度稳定的平面镜干涉仪(HSPMI))的高分辨率原位校准。 然后,校准的测量系统在剪切过程中测量机械倾斜。 倾斜数据用于校正剪切数据,优选在旋转不变(RI)项的计算之前。 或者,数据可以用于计算杂散二次项,并在积分后进行校正。

    Pump assembly
    67.
    发明申请
    Pump assembly 有权
    泵总成

    公开(公告)号:US20060184079A1

    公开(公告)日:2006-08-17

    申请号:US11325803

    申请日:2006-01-05

    IPC分类号: A61H7/00 A61H19/00

    CPC分类号: A47C27/082 A61G7/05776

    摘要: A pump assembly (200) for therapeutic inflatable cell apparatus, the assembly comprising a common pump unit (210), control means (160), and, first and second valve means (201;202), each valve means comprising a cycle control valve means, said cycle control valve means being provided with at least one fluid passageway and each valve means being adapted to be positioned to predetermined conditions so as to regulate fluid quantity in respective therapeutic inflatable cell apparatus, each valve means is adapted to perform at least one respective inflation/deflation sequence, and the assembly being such that, in use, on air being required by a valve means at a particular instance during the respective inflation/deflation sequence, the control means activates the common pump unit and air is pumped to an air outlet to feed air to the at least two valve means, and the pump assembly being such that the first and second valve means are operable both singularly and simultaneously.

    摘要翻译: 一种用于治疗性充气细胞装置的泵组件(200),该组件包括公共泵单元(210),控制装置(160)以及第一和第二阀装置(201; 202),每个阀装置包括循环控制阀 装置,所述循环控制阀装置设置有至少一个流体通道,并且每个阀装置适于被定位到预定条件以便调节相应的治疗性可充气细胞装置中的流体量,每个阀装置适于执行至少一个 相应的充气/放气顺序,并且组件使得在使用中,在相应的充气/放气序列期间在特定情况下由阀装置需要空气,控制装置激活公共泵单元,并且将空气泵送到 空气出口以将空气供给到所述至少两个阀装置,并且所述泵组件使得所述第一和第二阀装置可单独地同时操作。

    Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies

    公开(公告)号:US20060099182A1

    公开(公告)日:2006-05-11

    申请号:US11300698

    申请日:2005-12-14

    IPC分类号: A61K48/00 A61K9/127

    摘要: The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors.

    Apparatus and method of dispensing fluid
    70.
    发明申请
    Apparatus and method of dispensing fluid 有权
    分配液体的装置和方法

    公开(公告)号:US20060091153A1

    公开(公告)日:2006-05-04

    申请号:US11199587

    申请日:2005-08-08

    IPC分类号: G01F11/00 B67B7/00

    CPC分类号: G01F11/262 G01F11/26

    摘要: An apparatus for dispensing a flowable substance (e.g., a fluid) has a first housing with an indicating apparatus and a pour chamber. The indicating apparatus may have an indicating chamber with an indicating inlet for receiving fluid. The indicating apparatus also has indicia identifying amounts of fluid flowing through the pour chamber. The pour chamber has a pour inlet for receiving fluid, and an outlet in fluid communication with the pour inlet. To provide a definite separation, the first housing additionally has a wall between the indicating chamber and the pour chamber.

    摘要翻译: 用于分配可流动物质(例如流体)的装置具有带有指示装置和倾倒室的第一壳体。 指示装置可以具有指示室,其具有用于接收流体的指示入口。 指示装置还具有识别流过倾倒室的流体的量的标记。 倾倒室具有用于接收流体的倾倒入口和与倾倒入口流体连通的出口。 为了提供确定的分离,第一壳体还在指示室和倾倒室之间具有壁。