摘要:
The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.
摘要:
The present invention relates to releasable fusogenic lipids and nanoparticle compositions containing the same for the delivery of oligonucleotides and methods of modulating gene expression using the same. In particular, this invention relates to releasable fusogenic lipids containing an imine linker and a zwitterionic moiety.
摘要:
A process for preparing an ink jet print head front face or nozzle plate having a textured superoleophobic surface comprising providing a silicon substrate; using photolithography to create a textured pattern in the silicon substrate; optionally, modifying the textured silicon surface by disposing a conformal oleophobic coating thereon; and forming an ink jet print head front face or nozzle plate from the textured oleophobic silicon material to provide an ink jet print head front face or nozzle plate having a textured superoleophobic surface.
摘要:
Apparatuses and methods for model quality estimation and model adaptation in multivariable process control are disclosed. A method for updating a multiple input multiple output (MIMO) dynamical model of a process includes perturbing the process, auditing the controller model, identifying poor performing submodels and re-testing the relevant process variables, re-identifying submodels and adapting the model online while the process continues to operate within normal operating parameters. An apparatus comprises an online multivariable controller, a tester, a database to store data corresponding to manipulated variables and controlled variables, and a performance diagnosis module configured to identify problematic submodels and adapt a model used by the controller.
摘要:
A coating for an ink jet printhead front face, wherein the coating comprises a low adhesion coating, wherein when the low adhesion coating is disposed on an ink jet printhead front face surface, jetted drops of ultra-violet gel ink or jetted drops of solid ink exhibit a low sliding angle with the printhead front face surface, wherein the low sliding angle is less than about 1° to less than about 30°. In embodiments, the low adhesion coating is an oleophobic coating that exhibits a contact angle of greater than about 35° with ultra-violet gel ink or solid ink.
摘要:
Embodiments of methods are provided for transferring a user identity from one wireless communication device to another in a wireless communication system having a network system controller. A first device sends a deactivation request to the network controller, which includes information identifying the first device and a second device. The second device sends an activation request to the network system controller, which includes the information identifying the second device. The first device also sends repertoire information to the second device via the network system controller. The repertoire information is associated with the first device, and is selected from a group consisting of personal phone books, stored messages, stored recent call logs, and calendar information.
摘要:
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译:适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr(“linaclotide”)或其药学上可接受的盐组成的多肽。 本文所述的利那洛肽制剂是稳定的并且具有用于制造,储存和分配药物的足够的保质期。
摘要:
A method and system is provided for treating wastewater. In one process, wastewater is directed into a treatment tank and biologically treated. The biologically treated wastewater is directed as mixed liquor from the treatment tank to a bottom portion of a downstream filtration tank having at least one submerged membrane module that extends across substantially the entire cross sectional area of the filtration tank mixed liquor is directed from the bottom of the filtration tank upwardly into the membrane module such that substantially all of the mixed liquor received in the bottom of the filtration tank flows through the membrane module. As the mixed liquor flows vertically through the membrane module, the method includes inducing at least some of the mixed liquor through walls of one or more membrane filters that form a part of the membrane module, producing a permeate stream. The remaining mixed liquor passing through and from the membrane module is referred to as a non-permeate stream and the non-permeate stream, or at least a substantial portion thereof, is recirculated to the treatment tank. The filtration tank is sized relative to the membrane module and the process is carried out such that there is no substantial recycle of mixed liquor in the filtration tank itself. Although mixed liquor may be recirculated from the filtration tank back to the treatment tank and then back to the filtration tank and so forth and so on, once the mixed liquor in the filtration tank makes one pass through the membrane module the mixed liquor is recycled back to the treatment tank and generally not permitted to be recycled back through the membrane module without first returning to the treatment tank.
摘要:
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要:
The present invention provides releasably-linked indenoisoquinoline polymer conjugates. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.