公开(公告)号：US08398617B2

公开(公告)日：2013-03-19

申请号：US12609744

申请日：2009-10-30

申请人： Alec Ginggen ,  John Hoofnagle ,  Salim Kassem ,  Krista Moniz

发明人： Alec Ginggen ,  John Hoofnagle ,  Salim Kassem ,  Krista Moniz

IPC分类号： A61M5/00 ,  A61K9/22

CPC分类号： A61M27/006 ,  F16K31/08 ,  F16K37/0041 ,  Y10T137/8242

摘要： Integrated tools for noninvasively reading and adjusting an implantable, magnetically adjustable valve, and methods of use are disclosed. The tools include magnetic or electronic reading of the valve, and magnetic or electromagnetic adjustment of the valve. In use, the tools are positioned above or in contact with the patient's skin, in proximity to the valve.

公开(公告)号：US08366720B2

公开(公告)日：2013-02-05

申请号：US11461231

申请日：2006-07-31

申请人： Vladimir Mitelberg ,  John H. Thinnes, Jr. ,  Keith Balgobin ,  William W. Sowers

发明人： Vladimir Mitelberg ,  John H. Thinnes, Jr. ,  Keith Balgobin ,  William W. Sowers

IPC分类号： A61B17/12

CPC分类号： A61B17/12022 ,  A61B2017/12054 ,  A61B2090/037

摘要： An interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to a method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.

摘要翻译： 在身体容器内可操作的介入医疗装置系统设置有大致中空的管状近端部分，远侧部分和中间部分。 近端部分和远侧部分的至少一部分在使用中保持在身体的外部，而远侧部分的其余部分位于体内。 中间部分包括具有相邻匝的螺旋带，在两个相邻匝之间具有至少一个易碎的桥构件。 近端部分和远端部分通过延长螺旋带并且最终破坏易碎的桥接部件而彼此远离。 根据使用这种系统来部署可植入医疗装置（例如栓塞线圈）的方法，致动构件与近端部分向近侧移动以使致动构件和可植入医疗装置之间的结合或关节脱离。

公开(公告)号：US20130006345A1

公开(公告)日：2013-01-03

申请号：US13608532

申请日：2012-09-10

申请人： Vladimir Mitelberg ,  John H. Thinnes, JR. ,  Keith Balgobin ,  William W. Sowers

发明人： Vladimir Mitelberg ,  John H. Thinnes, JR. ,  Keith Balgobin ,  William W. Sowers

IPC分类号： A61F2/84

CPC分类号： A61B17/12022 ,  A61B2017/12054 ,  A61B2090/037

摘要： Use of an interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to the method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.

摘要翻译： 在身体容器内可操作的介入医疗装置系统的使用设置有大致中空的管状近端部分，远侧部分和中间部分。 近端部分和远侧部分的至少一部分在使用中保持在身体的外部，而远侧部分的其余部分位于体内。 中间部分包括具有相邻匝的螺旋带，在两个相邻匝之间具有至少一个易碎的桥构件。 近端部分和远端部分通过延长螺旋带并且最终破坏易碎的桥接部件而彼此远离。 根据使用这种系统来部署诸如栓塞线圈的可植入医疗装置的方法，致动构件与近侧部分向近侧移动，以解除致动构件和可植入医疗装置之间的结合或接合。

公开(公告)号：US08313442B2

公开(公告)日：2012-11-20

申请号：US12625627

申请日：2009-11-25

申请人： Salim Kassem

发明人： Salim Kassem

IPC分类号： A61B5/00

CPC分类号： A61B5/031 ,  A61B5/4064 ,  A61B5/7239

摘要： A system and method for monitoring cerebral compliance of a patient by placing a first pressure sensor in a first sub-dural location, preferably a sub-meningeal location, within the brain of the patient and placing at least a second pressure sensor in a second sub-dural location, preferably a sub-meningeal location, within the brain which is different from the first location. At least one parameter from each of the signals derived from the pressure sensors is compared to estimate cerebral compliance for the patient. Alternatively, at least a single pressure sensor is utilized with a generator of reference signals having at least two different frequencies. Preferably, any change in cerebral compliance is detected by determining a change in the compared parameter, and a perceptible indication is generated when cerebral compliance deviates beyond a pre-selected value.

摘要翻译： 一种用于通过将第一压力传感器放置在患者脑内的第一次硬膜下位置，优选地脑膜下位置来监测患者的大脑依从性的系统和方法，并且将至少第二压力传感器放置在第二子 在第一位置不同的大脑内部的位置，优选地脑膜下位置。 将来自压力传感器的每个信号的至少一个参数进行比较以估计患者的脑依从性。 或者，至少使用单个压力传感器与具有至少两个不同频率的参考信号的发生器。 优选地，通过确定比较的参数的变化来检测脑依从性的任何变化，并且当脑依从性偏离超过预选值时产生可察觉的指示。

公开(公告)号：US08288444B2

公开(公告)日：2012-10-16

申请号：US13172810

申请日：2011-06-29

申请人： Sean Lilienfeld ,  Thomas M DiMauro

发明人： Sean Lilienfeld ,  Thomas M DiMauro

IPC分类号： A61K31/535 ,  A61K31/12 ,  A61K31/22 ,  A61N1/30

CPC分类号： A61K31/221 ,  A61K9/0009 ,  A61K9/7023 ,  A61K31/09 ,  A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/22 ,  A61K31/223 ,  C07C229/12 ,  C07C229/34 ,  C07C271/54

摘要： A device for iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer's Disease patient.

摘要翻译： 用于离子电渗疗法将带电的姜黄素转运到阿尔茨海默病患者的皮肤上的装置。

公开(公告)号：US08252744B2

公开(公告)日：2012-08-28

申请号：US12709920

申请日：2010-02-22

申请人： Vedrana Stojanovic-Susulic ,  Ramakrishna Venugopalan ,  Mark Cunningham

发明人： Vedrana Stojanovic-Susulic ,  Ramakrishna Venugopalan ,  Mark Cunningham

IPC分类号： A61K38/34 ,  C07K2/00

CPC分类号： A61K38/34 ,  A61K47/6811 ,  A61K47/6849

摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

摘要翻译： 提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。 食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

公开(公告)号：US08216292B2

公开(公告)日：2012-07-10

申请号：US12495518

申请日：2009-06-30

申请人： Marc W. Litzenberg ,  Donald K. Jones ,  Vladimir Mitelberg

发明人： Marc W. Litzenberg ,  Donald K. Jones ,  Vladimir Mitelberg

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/1214 ,  A61B2017/00473 ,  A61B2017/1205 ,  A61B2017/12068 ,  A61B2017/12072 ,  A61B2017/12081

摘要： A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device. The expandable reaction chamber, prior to deployment, has multiple chambers separated by a heat-dissolvable membrane. When the membrane is dissolved, components from the chambers react and expand, leading to deployment.

摘要翻译： 一种血管闭塞装置展开系统，用于将闭塞装置放置在患者脉管系统内的预选部位。 采用具有在推动器的远端具有开口的内腔的推动器的展开系统。 血管闭塞装置通过可移除地设置在开口内的部分连接到推动器的远端。 闭塞装置的部分被可膨胀的反应室从开口压出，从而展开闭塞装置。 在展开之前，可膨胀反应室具有由热可溶性隔膜隔开的多个室。 当膜溶解时，来自室的组分反应并膨胀，导致部署。

公开(公告)号：US08197442B2

公开(公告)日：2012-06-12

申请号：US11741116

申请日：2007-04-27

申请人： Keith Balgobin ,  Vladimir Mitelberg ,  Jason T. Rainer ,  John H. Thinnes, Jr.

发明人： Keith Balgobin ,  Vladimir Mitelberg ,  Jason T. Rainer ,  John H. Thinnes, Jr.

IPC分类号： A61M29/00

CPC分类号： A61B17/1214 ,  A61B17/00234 ,  A61B17/12022 ,  A61B90/39 ,  A61B90/80 ,  A61B2017/00292 ,  A61B2017/00526 ,  A61B2017/12054 ,  A61B2090/3966 ,  A61M25/0012 ,  A61M25/0108 ,  B21D39/046 ,  Y10T29/49904 ,  Y10T29/49908

摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a slotted section. A radiopaque marker is secured to at least a portion of the slotted section such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the slotted section is formed by a laser cutting operation and a pre-assembly radiopaque marker member is crimped onto the slotted section.

摘要翻译： 提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。 推动器部件包括具有开槽部分的管状部分。 不透射线的标记被固定到开槽部分的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面基本上齐平，并且和/或紧邻不透射线标记的远侧。 根据制造这种部件的方法，通过激光切割操作形成开槽部分，并将预组装不透射线的标记部件压接到开槽部分上。

公开(公告)号：US08147480B2

公开(公告)日：2012-04-03

申请号：US12157070

申请日：2008-06-07

申请人： John R. Hoofnagle ,  Schorn Greg ,  Terri Kapur ,  Daniel Keeley

发明人： John R. Hoofnagle ,  Schorn Greg ,  Terri Kapur ,  Daniel Keeley

IPC分类号： A61M25/00

CPC分类号： A61M25/0023 ,  A61M25/0054 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/007 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/04 ,  A61M2025/0024 ,  A61M2025/0063

摘要： A therapeutic agent delivery system that includes a catheter having a proximal end and an opposite distal end. The catheter has a body with a lumen defined therein. The body of the catheter includes a non-bulbous region having a substantially uniform outer diameter and a bulbous region made from an elastically deformable material. While in a first state the bulbous region has a maximum outer diameter greater than the substantially uniform outer diameter of the non-bulbous region; and while in a second state the maximum outer diameter of the bulbous region is reduced relative to that while in the first state.

摘要翻译： 一种治疗剂递送系统，其包括具有近端和相对远端的导管。 导管具有其中限定有内腔的主体。 导管的主体包括具有基本上均匀的外径的非球形区域和由可弹性变形的材料制成的球形区域。 在第一状态下，球茎区域的最大外径大于非球形区域的基本均匀的外径; 而在第二状态下，球状区域的最大外径相对于第一状态时的最大外径减小。

公开(公告)号：US20120046595A1

公开(公告)日：2012-02-23

申请号：US12858193

申请日：2010-08-17

申请人： Stephen F. Wilson ,  Michael A. DeFusco

发明人： Stephen F. Wilson ,  Michael A. DeFusco

IPC分类号： A61M5/00

CPC分类号： A61M27/006 ,  F16K15/046 ,  F16K15/183 ,  F16K31/088 ,  F16K31/52425 ,  F16K35/16 ,  F16K37/0058 ,  Y10T137/7906 ,  Y10T137/8242

摘要： A valve unit capable of being implanted in a patient and having adjustable performance settings, such as pressure settings and/or flow control, to regulate passage of a bodily fluid. A casing defines a port for the bodily fluid, and a valve mechanism positioned at the port includes a movable valve member. The valve unit further includes a rotor disposed at a first location in the casing and having an axle which turns about an axis of rotation. The rotor defines a plurality of arcuate, radially flat cam surfaces. Each cam surface occupies an arc about the axis of rotation. A spring arm unit is disposed at a second location in the casing having a cam follower arm in slidable contact with the cam surfaces of the rotor and having a resilient spring element applying a closing effect with the movable valve member to establish a performance setting for the valve unit. Sufficient rotation of the rotor to change the cam surface in contact with the cam follower alters the closing effect with which the valve member moves relative to the port and thereby alters the performance setting of the valve unit.

摘要翻译： 能够植入患者体内并具有调节性能设置（例如压力设置和/或流量控制）以调节体液通过的阀单元。 壳体限定用于体液的端口，并且位于端口处的阀机构包括可移动的阀构件。 阀单元还包括设置在壳体中的第一位置处的转子，并且具有围绕旋转轴线转动的轴。 转子限定多个弧形的径向平坦的凸轮表面。 每个凸轮表面围绕旋转轴线占据弧。 弹簧臂单元设置在壳体中的第二位置处，具有与转子的凸轮表面滑动接触的凸轮从动臂，并具有弹性弹簧元件，该弹簧元件与可动阀构件施加闭合效果，以建立用于 阀门单元 转子的足够旋转以改变与凸轮从动件接触的凸轮表面，改变了阀构件相对于端口移动的关闭效果，从而改变了阀单元的性能设置。