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公开(公告)号：US5338512A
公开(公告)日：1994-08-16
申请号：US024998
申请日：1993-03-02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , B01D2313/105 , B01D2313/125 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译： 一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。 该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内 。 膜定义了与通过气体引导的血液通路分离的气体通路。 血液通过个体血液通路。 该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。
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公开(公告)号：US5240677A
公开(公告)日：1993-08-31
申请号：US853513
申请日：1992-03-18
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , F28F21/062 , A61M1/3627 , B01D2313/14 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A hollow fiber blood oxygenator is provided having a plurality of enclosed, coaxial heat exchanger coils, having a common header to insure uniform temperature in the coils. An enclosed fiber bundle is concentrically positioned inside the heat exchanger coils to define a flow path around the coils and through the fiber bundle. The heat exchanger coils and the outside of the fiber bundle are tapered to provide a close fit. Gas manifolds direct gas flow to and from the hollow fibers.
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公开(公告)号：US5217689A
公开(公告)日：1993-06-08
申请号：US428270
申请日：1989-10-26
申请人： Donald A. Raible
发明人： Donald A. Raible
CPC分类号： B01D63/025 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D63/02 , F28F21/062 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A blood oxygenation system includes an oxygenator for oxygenating blood and a heat exchanger for regulating blood temperature. The heat exchanger includes a heat exchange coil that provides a flow path for a heat exchange media, the heat exchange coil is configured to define a heat exchange zone, and the oxygenator is disposed in heat transfer relationship with the heat exchange zone in order to transfer heat between the heat exchange coil and the oxygenator. The heat exchange coil may at least partially circumscribe the oxygenator and, preferably, be helically shaped and disposed coaxially over a membrane oxygenator. In one embodiment, single or multiple hollow fiber strands are wound onto a small diameter center core so that the fiber segments provide spiralling helical blood-flow pathways which increase oxygen/carbon dioxide exchange by secondary flow paths.
摘要翻译： 血液氧合系统包括用于氧合血液的氧合器和用于调节血液温度的热交换器。 热交换器包括提供用于热交换介质的流动路径的热交换盘管，热交换盘管构造成限定热交换区，并且氧合器与热交换区以热传递关系设置，以便转移 热交换线圈和氧合器之间的热量。 热交换盘管可以至少部分地围绕氧合器，并且优选地被螺旋形地并且同轴地设置在膜充氧器上。 在一个实施方案中，将单个或多个中空纤维束卷绕到小直径的中心芯上，使得纤维段提供螺旋形的螺旋血流通路，其通过二次流动路径增加氧/二氧化碳交换。
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公开(公告)号：US5192499A
公开(公告)日：1993-03-09
申请号：US551942
申请日：1990-07-12
申请人： Satoru Sakai , Kiyohide Ishikawa
发明人： Satoru Sakai , Kiyohide Ishikawa
CPC分类号： A61M1/1698 , A61M1/1627 , B01D63/02 , B01D63/022 , Y10S128/03 , Y10S165/905 , Y10S165/906 , Y10S261/28
摘要： The fluid processing apparatus of the present invention comprises a housing having a first fluid inlet and a first fluid outlet; a fluid processing tubular means received in the housing; partitions securing the opposed ends of the fluid processing tubular means to the housing in a fluid tight seal to partition the housing interior into a first fluid chamber in fluid communication with the first fluid inlet and the first fluid outlet and a second fluid chamber defined in the fluid processing tubular means; a second fluid inlet and a second fluid outlet in fluid communication with the second fluid chamber; and projections formed on an inner surface of one end portion of the housing so as to project toward the nearer end opening of the housing, said partition of the one end portion side of said housing being secured to the one end portion of the housing so that the projections are positioned within the partition. Therefore, if a large annular portion where the fluid processing tubular means is not present is formed in the end portion of the housing, because the projections are positioned in the annular portion of the partition, shrinkage of the potting composition forming the partition is suppressed and any separation between the partition and the inner surface of the housing due to the shrinkage of the potting composition is prevented. Further, it is also prevented to form a weak bond portion between the partition and the inner surface of the housing.
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公开(公告)号：US5106579A
公开(公告)日：1992-04-21
申请号：US589020
申请日：1990-09-27
CPC分类号： B01D67/0088 , A61L33/064 , Y10S128/03 , Y10S261/28
摘要： A membrane type artificial lung uses a gas-exchange membrane having at least the surface thereof for exposure to blood or the minute pores therein coated or blocked with a vinyl type copolymer having as one of the components thereof a vinyl monomer possessing a perfluoroalkyl side chain. The gas-exchange membrane of the artificial lung is manufactured by a method which comprises bringing at least the surface of the gas-exchange membrane for exposure to blood into contact with a solution of the vinyl type copolymer and subsequently vaporizing the solvent in the solution.
摘要翻译： 膜式人造肺使用至少具有表面的气体交换膜，其中，作为其组分之一的具有全氟烷基侧链的乙烯基单体的乙烯基类共聚物涂覆或封闭的微细孔。 人造肺的气体交换膜通过以下方法制造：至少使用于暴露于血液的气体交换膜的表面与乙烯基类共聚物的溶液接触，然后使溶剂中的溶剂蒸发。
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公开(公告)号：US4902476A
公开(公告)日：1990-02-20
申请号：US56135
申请日：1987-05-29
CPC分类号： B01D63/02 , A61M1/1627 , A61M1/1629 , A61M1/1698 , A61M5/44 , A61M1/32 , A61M1/369 , A61M2205/366 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A heat exchanger and blood oxgenator apparatus includes a housing having a blood inlet portion, a blood outlet portion, and a housing wall defining an enclosed chamber disposed along a chamber axis between the blood input portion and the blood output portion through which to pass a quantity of blood to be temperature controlled. A heat exchanger tube having an exterior surface and a hollow interior through which to pass a heat exchange medium for purposes of exchanging heat with a quantity of blood brought into contact with the exterior surface, is disposed in a generally helical coil that is mounted within the chamber to encircle the chamber axis. A scalloped inner surface is included on the housing wall to face generally inward toward the heat exchanger tube. Spacing members disposed between the exterior surface of the heat exchanger tube and the scalloped inner surface of the housing wall retain the exterior surface spaced apart from the scalloped inner surface to define a flow passage through which to pass a quantity of blood so that the blood contacts a substantial portion of the exterior surface.
摘要翻译： 热交换器和血液氧化器装置包括具有血液入口部分，血液出口部分和壳体壁的壳体，该壳体限定了沿着血液输入部分和血液输出部分之间的腔室轴线设置的封闭腔室， 的血液要温度控制。 具有外表面和中空内部的热交换器管被设置在大致螺旋状的线圈中，所述外部表面和中空内部通过热交换介质以通过与外部表面接触的一定量的血液进行热交换。 腔室围绕腔室轴线。 扇形内表面包括在壳体壁上，以朝向热交换器管大致向内。 设置在热交换器管的外表面和壳体壁的扇形内表面之间的间隔构件保持与扇形内表面间隔开的外表面，以限定通过一定量血液的流动通道，使得血液接触 外表面的大部分。
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公开(公告)号：US4781889A
公开(公告)日：1988-11-01
申请号：US81536
申请日：1987-08-03
CPC分类号： B01D67/0088 , B01D61/38 , B01D63/02 , B01D63/021 , B01D2323/283 , Y10S128/03 , Y10S261/28
摘要： A hollow fiber membrane type artificial lung and a method for the manufacture thereof. The artificial lung comprises a housing, a hollow fiber bundle positioned in the housing and formed of a multiplicity of gas-exchange hollow fiber membranes, a first fluid chamber defined by the external surfaces of the hollow fiber membranes and the internal surface of the housing, a first fluid inlet and a first fluid outlet both communicating with the first fluid chamber, partitions supporting in place the opposite ends of the hollow fibers and provided at the inner face of the housing, and a second fluid inlet and a second fluid outlet allowed to communicate with the empty spaces inside the hollow fiber membranes, which artificial lung is characterized by the fact that the hollow fiber membranes are produced by causing porous hollow fiber substrates which have through micropores distributed in the walls thereof to be treated with silicone oil so that the silicone oil will block up said micropores without forming a silicone oil layer on the internal surfaces of the walls of the porous hollow fiber substrates.
摘要翻译： 中空纤维膜型人造肺及其制造方法。 人造肺包括壳体，定位在壳体中并由多个气体交换中空纤维膜形成的中空纤维束，由中空纤维膜的外表面和壳体的内表面限定的第一流体室， 第一流体入口和第一流体出口，其与第一流体室连通，分隔件支撑中空纤维的相对端并设置在壳体的内表面，并且允许第二流体入口和第二流体出口允许 与中空纤维膜内的空白空间连通，该人造肺的特征在于中空纤维膜是通过使分布在其壁中的微孔的多孔中空纤维基材用硅油处理而制造的， 硅油将堵塞所述微孔而不在孔的壁的内表面上形成硅油层 我们中空纤维基材。
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68.发明授权Gas driven system for preparing large volumes of non-oxidized, pyridoxylated, polymerized stroma-free hemoglobin solution for use as a blood substitute 失效气体驱动系统，用于制备大量未氧化，吡哆醛化，无聚合的无基质血红蛋白溶液，用作血液替代品
公开(公告)号：US4730936A
公开(公告)日：1988-03-15
申请号：US917573
申请日：1986-10-10
IPC分类号： B01F3/04 , C07K14/805 , B01F13/02
CPC分类号： C07K14/805 , B01F3/04099 , Y10S261/28
摘要： An apparatus and method for reacting dilute concentrations of delicate bioorganics or other reactants without creating microconcentrations of reactant during the reaction process. The apparatus mixes reagents inside of Y-connector with flowing solution from a solution reservoir. The reagents are introduced through a stopcock controlled infusion port at the center of the Y-connector. Solution and pressurized gas are each supplied to one of the three legs of the Y-connector and the resulting mixed solution from the third leg of the Y-connector is lifted by bubbles of the pressurized gas to return to the solution reservoir. A gaseous separation unit is placed inside the solution reservoir wherein the bubble lifted and mixed solution is forced through a permeable membrane enclosed by a perforated bulb to return to the reservoir. The perforated bulb is enclosed inside an additional enclosure having an opening below the solution level of the reservoir so that the returning solution will flow beneath the opening to the larger reservoir area and the excess gas will escape above the solution level through vent holes in the additional enclosure. Additional pressurized gas is delivered to the enclosure opening to bubble over the outside of the perforated bulb. A second Y-connector may be added between the first Y-connector and the solution reservoir.
摘要翻译： 在稀释的浓度的精细生物有机物或其他反应物中反应的装置和方法，而不会在反应过程中产生反应物的微量浓度。 该装置将Y型连接器内的试剂与来自溶液储存器的流动溶液混合。 试剂通过Y型连接器中心的活塞控制的输液口引入。 溶液和加压气体分别供应到Y型连接器的三条腿中的一条，并且由Y型连接器的第三条腿形成的混合溶液被加压气体的气泡提升，以返回溶液储存器。 将气体分离单元放置在溶液储存器内部，其中气泡提升并且混合溶液被迫通过由穿孔灯泡包围的可渗透膜返回到储存器。 穿孔的灯泡被封闭在具有在储存器的溶液液面以下的开口的另外的外壳中，使得返回的溶液将在开口下方流动到较大的储存区域，并且过量的气体将通过附加的通气孔中的溶液水平逸出 外壳。 附加的加压气体被输送到外壳开口以在穿孔的灯泡的外部气泡。 可以在第一Y型连接器和溶液储存器之间添加第二Y型连接器。
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69.发明授权Apparatus for the transfer of one or more substances between a gas and a liquid 失效用于在气体和液体之间转移一种或多种物质的装置
公开(公告)号：US4533516A
公开(公告)日：1985-08-06
申请号：US395283
申请日：1982-07-06
CPC分类号： A61M1/32 , Y10S261/28
摘要： An apparatus for the transfer of one or more substances between a gas and a liquid, for example between an oxygen-containing gas and blood, is disclosed. The apparatus includes a plurality of concentric vessels which define a flow path for the liquid, and which includes along a portion of the path an annular heat exchange chamber having a first end at which the liquid is introduced into the chamber and a second end at which the liquid is conducted from the chamber. A heat exchanger is supported in the heat exchange chamber for conducting a heat exchange fluid in heat exchange relationship with the liquid as the liquid flows through the chamber. Gas in the form of bubbles is introduced into the liquid as the liquid is conducted along the flow path to thereby effect transfer of substances between the gas and the liquid, the gas being introduced upstream of the first end of the heat exchange chamber. A plurality of throttling ports are arranged about the periphery of the annular heat exchange chamber at the second end of the chamber for conducting the liquid from the heat exchange chamber. Downstream of the second end of the heat exchange chamber, excess gas is removed from the liquid together with substances transferred from the liquid to the gas. By means of this arrangement, a very uniform and homogeneous flow around the entire periphery of the heat exchange chamber is provided, which in turn insures that a good heat transfer and gas exchange is obtained.
摘要翻译： 公开了一种用于在气体和液体之间例如在含氧气体和血液之间转移一种或多种物质的装置。 该装置包括多个同心的容器，其限定了用于液体的流动路径，并且其包括沿着路径的一部分，环形热交换室具有第一端，液体在该第一端被引入腔室，第二端在该第二端 液体从腔室传导。 热交换器被支撑在热交换室中，用于当液体流过腔室时与液体发生热交换的热交换流体。 当液体沿着流动路径传导时，气体形式的气体被引入到液体中，从而在气体和液体之间进行物质的转移，气体被引入到热交换室的第一端的上游。 在室的第二端围绕环形热交换室的周边布置多个节流口，用于从热交换室引导液体。 在热交换室的第二端的下游，从液体向气体转移的物质一起从液体中除去过量的气体。 通过这种布置，提供了围绕热交换室的整个周边的非常均匀且均匀的流动，这又确保了获得良好的传热和气体交换。
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70.发明授权
公开(公告)号：US4328102A
公开(公告)日：1982-05-04
申请号：US206545
申请日：1980-06-12
IPC分类号： F28D9/00 , A61M20060101 , A61M1/00 , A61M1/22 , B01D20060101 , B01D61/14 , B01D61/18 , B01D61/20 , B01D61/24 , B01D61/30 , B01D63/08 , B01D63/16 , B01D65/08 , F28F20060101 , B01D31/00
CPC分类号： B01D63/085 , B01D2313/08 , B01D2313/243 , Y10S128/03 , Y10S261/28
摘要： A dialyser has a membrane assembly (12) comprising two superposed conduits partially defined, and separated, by a transfer membrane wall. The walls of the conduit are provided with furrowing (38 or 39) extending with a component along the conduits. Blood is pumped through one conduit by a roller pump (21) and dialysate is pumped in counter current through the other conduit by a roller pump (24). The conduits communicate with separate chambers in flexible bladders (16) along each side edge of the conduits and the bladders are alternately compressed by rollers (27) to provide a superimposed reciprocatory flow component on the blood and dialysate in a direction transverse to the length of the conduits. This reciprocatory flow component, in conjunction with the furrows, produces vortexes in, and good mixing of, the blood and dialysate in their respective conduits and hence enhanced contact of each of these liquids with the transfer membrane wall.
摘要翻译： 透析器具有膜组件（12），其包括部分限定并由转移膜壁分离的两个重叠管道。 导管的壁上设置有沿着导管沿着部件延伸的沟槽（38或39）。 通过一个滚子泵（21）将血液泵送通过一个导管，透析液通过一个滚子泵（24）以相反的电流泵送通过另一个导管。 导管沿着管道的每个侧边缘与柔性囊（16）中的分开的腔室连通，并且气囊被辊子（27）交替地压缩，以在血液和透析液的横向方向上横向延伸的方向提供叠加的往复流动分量 导管。 这种往复流动成分与沟槽结合，在它们各自的管道中产生涡流并且充分混合血液和透析液，并因此增强了这些液体与转移膜壁的接触。
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