公开(公告)号：US12042580B2

公开(公告)日：2024-07-23

申请号：US15938537

申请日：2018-03-28

Applicant: Covalon Technologies Ltd.

Inventor： Daryl Sivakumaran ,  Darryl Knight ,  Vyacheslav Dudnyk ,  Valerio DiTizio

IPC: A61L33/00 ,  A61L33/06 ,  C08F220/06 ,  C09D4/00 ,  C09D5/14 ,  C09D133/10

CPC classification number: A61L33/0088 ,  A61L33/0005 ,  A61L33/0035 ,  A61L33/0094 ,  A61L33/064 ,  C08F220/06 ,  C09D4/00 ,  C09D5/14 ,  C09D133/10 ,  A61L2300/404 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  C08F220/06 ,  C08F220/14 ,  C09D4/00 ,  C08F220/06

Abstract: A coating composition comprises an aqueous solution comprising at least one vinyl carboxylic acid monomer and at least one neutral monomer, wherein the at least one neutral monomer has a glass transition temperature of less than about 100° C. in homopolymeric form. A device comprises a protonated polyacrylate coating, wherein the device is inherently antimicrobial, anti-thrombogenic, flexible, and/or sheds few to no particulates.

公开(公告)号：US20180127594A1

公开(公告)日：2018-05-10

申请号：US15804809

申请日：2017-11-06

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Sung Hoon KANG ,  Philseok KIM ,  Tak Sing WONG

IPC: C09D5/00 ,  C09D5/16 ,  H01L31/0236 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  C10M105/56 ,  F28F13/18 ,  F28F19/02 ,  B01L3/00 ,  C08L27/12 ,  B65D25/14 ,  F15D1/10 ,  F15D1/02 ,  F01D25/18 ,  B05D5/00 ,  B05D3/00 ,  C10M105/54 ,  B01D69/02 ,  B05D5/08 ,  B63B59/04 ,  B64D15/00 ,  C02F1/44 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F16L57/00 ,  H01L31/0216

CPC classification number: C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y02W10/37 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US09775933B2

公开(公告)日：2017-10-03

申请号：US13773937

申请日：2013-02-22

Applicant: W. L. Gore & Associates, Inc.

Inventor： Keith A. Knisley ,  Vishnu T. Marla ,  Rachel Radspinner ,  Paul A. Silvagni ,  Jason J. Strid ,  Michael J. Vonesh

IPC: A61F2/82 ,  A61L31/06 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06 ,  A61F2/00

CPC classification number: A61L31/06 ,  A61F2/0077 ,  A61F2/82 ,  A61F2002/009 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/007 ,  A61L33/064 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2400/12 ,  A61L2400/18 ,  C08L27/12 ,  C08L27/18

Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

公开(公告)号：US09731049B2

公开(公告)日：2017-08-15

申请号：US14519589

申请日：2014-10-21

Applicant: Angiodynamics Inc.

Inventor： Raymond Lareau ,  Benjamin Bell ,  J. Paul Santerre ,  Jeannette Ho

IPC: A61M25/00 ,  A61L29/04 ,  A61L29/18 ,  A61L33/06 ,  A61M25/098 ,  C08L75/04 ,  A61L29/14

CPC classification number: A61L29/041 ,  A61L29/049 ,  A61L29/14 ,  A61L29/18 ,  A61L33/062 ,  A61L33/064 ,  A61L2300/802 ,  A61M25/0017 ,  A61M25/0021 ,  A61M2025/0056 ,  C08L75/04 ,  C08L27/12

Abstract: The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.

公开(公告)号：US20170182223A1

公开(公告)日：2017-06-29

申请号：US15460899

申请日：2017-03-16

Applicant: Access Vascular, Inc.

Inventor： James F. Biggins ,  Michael Bassett ,  Daniel Donahue

IPC: A61L29/04 ,  A61L29/18 ,  C08J9/00 ,  A61L33/06 ,  A61L33/00 ,  C08J9/28 ,  A61L29/14 ,  A61L29/02

CPC classification number: A61L29/041 ,  A61L17/10 ,  A61L27/16 ,  A61L27/56 ,  A61L29/02 ,  A61L29/049 ,  A61L29/146 ,  A61L29/16 ,  A61L29/18 ,  A61L33/007 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/12 ,  A61M25/005 ,  B29C48/00 ,  B29C48/05 ,  B29C48/78 ,  B29C48/865 ,  B29C67/0029 ,  B29K2105/04 ,  B29L2031/753 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/28 ,  C08J2201/03 ,  C08J2201/0546 ,  C08J2205/042 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2329/04 ,  C08J2433/02 ,  D01F1/08 ,  D01F6/14 ,  D01F6/50 ,  C08L29/04

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

公开(公告)号：US20170157304A1

公开(公告)日：2017-06-08

申请号：US15362322

申请日：2016-11-28

Applicant: National University Corporation Yamagata University ,  NIPPON SHOKUBAI CO., LTD.

Inventor： Masaru TANAKA ,  Naoki KOBAYASHI ,  Yoshitomo NAKATA ,  Asuka SUGAWARA

IPC: A61L33/06 ,  C08F220/28 ,  C08F220/12

CPC classification number: A61L33/064 ,  C08F220/12 ,  C08F220/18 ,  C08F220/28 ,  C08F2220/282 ,  C08L33/04 ,  C08F2220/1825 ,  C08F220/20

Abstract: To Provide is a polymer having high antithrombogenicity compared to a conventional polymer having a glycerol group and suitable as a medical device material. It is the polymer having a structural unit derived from a glycerol group-containing monomer, and a structural unit derived from an unsaturated monomer having a structure in which an organic group having a structure site having 4 or more carbon atoms continuously bound is bound to an ethylenically unsaturated group; and satisfying a glass-transition temperature of 10° C. or less and/or a glass-transition temperature of −25° C. or less at a saturated water content.

公开(公告)号：US09668890B2

公开(公告)日：2017-06-06

申请号：US14087459

申请日：2013-11-22

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16 ,  A61F2/90

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0088 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/142

Abstract: Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

公开(公告)号：US20170151375A1

公开(公告)日：2017-06-01

申请号：US15429835

申请日：2017-02-10

Applicant: BioInteractions Ltd.

Inventor： Fanny Burrows ,  John E. Mckendrick ,  Alan Rhodes ,  Simon J. Onis ,  Shivpal S. Sandhu

IPC: A61L33/00 ,  C09D133/14 ,  C08F220/28 ,  G02B1/04 ,  A61L29/14 ,  A61L31/10 ,  A61L33/06 ,  C07F9/09 ,  A61L31/14 ,  C08F220/18 ,  A61L29/08

CPC classification number: A61L33/0023 ,  A61L27/34 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/064 ,  C07B2200/11 ,  C07F9/062 ,  C07F9/08 ,  C07F9/091 ,  C07F9/106 ,  C07F9/32 ,  C07F9/3205 ,  C07F9/36 ,  C07F9/40 ,  C07F9/4078 ,  C07F9/65742 ,  C08F8/30 ,  C08F8/40 ,  C08F16/14 ,  C08F18/22 ,  C08F30/02 ,  C08F116/14 ,  C08F122/02 ,  C08F130/02 ,  C08F216/14 ,  C08F220/18 ,  C08F220/28 ,  C08F222/02 ,  C08F230/02 ,  C08F2220/1825 ,  C08F2220/281 ,  C08F2220/285 ,  C09D133/14 ,  G02B1/043 ,  C08L33/26 ,  C08L33/10 ,  C08L33/12

Abstract: New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

公开(公告)号：US20160375180A1

公开(公告)日：2016-12-29

申请号：US15260829

申请日：2016-09-09

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Takao ANZAI

IPC: A61L33/00 ,  A61L33/06

CPC classification number: A61L33/0029 ,  A61L33/0005 ,  A61L33/0041 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/10 ,  A61L2420/02

Abstract: Provided is a method for preparing a medical device which has a surface lubricating layer on a surface of a substrate and the surface of which exhibits lubricity and antithrombotic qualities when being wet. The method includes forming a coating layer that contains a hydrophilic polymer having at least one reactive functional group selected from the group consisting of an epoxy group, an acid chloride group, and an aldehyde group, and then applying onto the coating layer an antithrombotic material solution that contains an antithrombotic material having a functional group capable of binding to the hydrophilic polymer to form the surface lubricating layer. The concentration of the antithrombotic material in the antithrombotic material solution is more than 0 and less than 0.1 wt %.

Abstract translation: 本发明提供一种在基材表面具有表面润滑层的制造方法，其表面在湿润时具有润滑性和抗血栓性。 该方法包括形成包含具有至少一个选自环氧基，酰氯基和醛基的反应性官能团的亲水性聚合物的涂层，然后在涂层上涂布抗血栓形成物质溶液 其含有具有能够结合亲水性聚合物的官能团形成表面润滑层的抗血栓形成材料。 抗血栓材料溶液中抗血栓形成材料的浓度大于0且小于0.1wt％。

公开(公告)号：US20150238664A1

公开(公告)日：2015-08-27

申请号：US14627351

申请日：2015-02-20

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Takao ANZAI

IPC: A61L33/06

CPC classification number: A61L33/064

Abstract: A medical material that is excellent in antithrombogenicity even under a severe use condition in which thrombi are easily formed, is provided. The medical material contains a water-insoluble copolymer including a repeating unit (A) (which is derived from acryloylmorpholine, for example) and a repeating unit (B) (which is derived from methoxyethyl acrylate, for example), in which the water-insoluble copolymer has 5 mole % to 20 mole % of the repeating unit (A) with respect to all constituent units of the copolymer.

Abstract translation: 提供即使在容易形成血栓的严重使用条件下也具有优异的抗血栓形成性的医疗用材料。 医药材料含有包含重复单元（A）（例如衍生自丙烯酰吗啉的）的水不溶性共聚物和例如衍生自丙烯酸甲氧基乙酯的重复单元（B）），其中， 不溶性共聚物相对于共聚物的所有构成单元，具有5重量％〜20摩尔％的重复单元（A）。