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    Methods, apparatuses, and applications for compliant membrane blood gas exchangers
    3.
    发明授权
    Methods, apparatuses, and applications for compliant membrane blood gas exchangers 有权
    用于顺应性膜血气换气器的方法，装置和应用

    公开(公告)号：US08409502B2

    公开(公告)日：2013-04-02

    申请号：US11211115

    申请日：2005-08-24

    申请人： Robert N. Schaap ,  Barry Bagley

    发明人： J D Mortensen ,  Robert N. Schaap ,  Barry Bagley

    IPC分类号： A61M1/00 ,  A61M37/00

    CPC分类号： A61M1/16 ,  A61M1/1625 ,  A61M1/1698 ,  Y10S128/03 ,  Y10S261/28

    摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.

    摘要翻译： 提供了一种兼容的血液气体交换器，其包括具有第一端盖，第二端盖和在其之间延伸形成腔室的弹性体侧壁或套管的壳体。 中空纤维组件设置在腔室中。 中空纤维组件具有第一安装套环，第二安装环和布置在其间的多个中空纤维。 第一端盖设置成与第一安装轴环连通，并且第二端盖设置成与第二安装轴环连通。 端盖连接到气体入口和气体出口。 腔室与血液入口和血液出口连通。 弹性体侧壁响应影响腔室的内部和外部压力。 第一室也可以放置在第二室附近，并且两个室都放置在刚性外壳内。 因此，可以提供双室脉动血液换气器。 也就是说，第二室可以与泵机构或真空机构连接，使得室在第一室内产生脉动流。

    Active air removal system operating modes of an extracorporeal blood circuit
    5.
    发明授权
    Active air removal system operating modes of an extracorporeal blood circuit 有权
    活体除气系统体外血液循环的运行模式

    公开(公告)号：US07704455B2

    公开(公告)日：2010-04-27

    申请号：US11702480

    申请日：2007-02-05

    申请人： Robert W. Olsen ,  Walter L. Carpenter ,  John B. Dickey ,  Mark D. Stringham

    发明人： Robert W. Olsen ,  Walter L. Carpenter ,  John B. Dickey ,  Mark D. Stringham

    IPC分类号： A61M37/00 ,  C02F1/44

    CPC分类号： A61M1/3643 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3644 ,  A61M1/3666 ,  A61M1/3667 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/082 ,  Y10S261/28

    摘要： A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.

    摘要翻译： 在体外循环手术中使用的一次性，一体化的体外血液回路以节省体积，减少安装和更换时间，消除静脉血液储存器的方式进行气体交换，热传递和微栓塞过滤功能，并显着减少 血液空气界面。 来自患者或主溶液的血液通过装备有用于检测空气的空气传感器的空气去除装置。 主动除气控制器从空气去除装置中的血液中除去检测到的空气。 一次性电路支持模块用于将一次性的，集成的体外血液回路的部件安装在非常接近的位置并且具有期望的空间关系，以优化一次性的，集成的体外血液回路的灌注和使用。 一个可重复使用的电路支架支持一次性电路支撑模块相对于主要解决方案源，主动空气去除控制器和其他组件。

    Extracorporeal blood circuit priming system and method
    6.
    发明授权
    Extracorporeal blood circuit priming system and method 有权
    体外血液灌注系统和方法

    公开(公告)号：US07682563B2

    公开(公告)日：2010-03-23

    申请号：US11706005

    申请日：2007-02-14

    申请人： Walter L. Carpenter ,  Robert W. Olsen ,  Frederick A. Shorey, Jr. ,  Mark G. Bearss ,  Bruce R. Jones ,  Laura A. Yonce

    发明人： Walter L. Carpenter ,  Robert W. Olsen ,  Frederick A. Shorey, Jr. ,  Mark G. Bearss ,  Bruce R. Jones ,  Laura A. Yonce

    IPC分类号： A61M37/00 ,  C02F1/44

    CPC分类号： A61M1/3627 ,  A61M1/3626 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3666 ,  A61M1/3667 ,  A61M2205/505 ,  A61M2209/082 ,  Y10S261/28

    摘要： A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.

    摘要翻译： 在体外循环手术中使用的一次性，一体化的体外血液回路以节省体积，减少安装和更换时间，消除静脉血液储存器的方式进行气体交换，热传递和微栓塞过滤功能，并显着减少 血液空气界面。 来自患者或主溶液的血液通过装备有用于检测空气的空气传感器的空气去除装置。 主动除气控制器从空气去除装置中的血液中除去检测到的空气。 一次性电路支持模块用于将一次性的，集成的体外血液回路的部件安装在非常接近的位置并且具有期望的空间关系，以优化一次性的，集成的体外血液回路的灌注和使用。 一个可重复使用的电路支架支持一次性电路支撑模块相对于主要解决方案源，主动空气去除控制器和其他组件。

    Generation and usage of microbubbles as a blood oxygenator
    7.
    发明授权
    Generation and usage of microbubbles as a blood oxygenator 失效
    微泡作为血液充氧器的生成和使用

    公开(公告)号：US07303156B1

    公开(公告)日：2007-12-04

    申请号：US10847718

    申请日：2004-05-18

    申请人： Sung Sam Kim ,  Roy Schubert

    发明人： Sung Sam Kim ,  Roy Schubert

    IPC分类号： B05B1/04

    CPC分类号： A61M1/32 ,  A61M1/1678 ,  Y10S261/28

    摘要： A micro-nozzle for generating micro-bubbles. The micro-nozzle includes a liquid inlet forming a liquid path, a gas inlet, and a constricting wall positioned in the liquid path and shaped to abruptly constrict said liquid path to a width of less than approximately 20 um and then gradually diverge.

    摘要翻译： 用于产生微气泡的微型喷嘴。 微型喷嘴包括形成液体通道的液体入口，气体入口和收缩壁，其定位在液体通道中并成形为将所述液体通道突然收缩至小于约20μm的宽度，然后逐渐发散。

    Disposable,integrated extracorporeal blood circuit
    8.
    发明申请
    Disposable,integrated extracorporeal blood circuit 审中-公开
    一次性，综合体外血液回路

    公开(公告)号：US20070148037A1

    公开(公告)日：2007-06-28

    申请号：US11707016

    申请日：2007-02-13

    申请人： Walter Carpenter ,  Robert Olsen ,  Stefanie Heine ,  Frederick Shorey ,  Laura Yonce

    发明人： Walter Carpenter ,  Robert Olsen ,  Stefanie Heine ,  Frederick Shorey ,  Laura Yonce

    IPC分类号： A61M1/00

    CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1086 ,  A61M1/1089 ,  A61M1/1629 ,  A61M1/32 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3639 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3666 ,  A61M1/3667 ,  A61M2205/3379 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/8206 ,  A61M2209/08 ,  A61M2209/082 ,  Y10S261/28

    摘要： A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and. microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.

    摘要翻译： 在体外循环手术中使用的一次性，综合的体外血液回路进行气体交换，热传递和。 微栓塞过滤功能以节省体积，减少安装和更换时间，消除静脉血液储存器，并显着减少血液 - 空气界面。 来自患者或主溶液的血液通过装备有用于检测空气的空气传感器的空气去除装置。 主动除气控制器从空气去除装置中的血液中除去检测到的空气。 一次性电路支持模块用于将一次性的，集成的体外血液回路的部件安装在非常接近的位置并且具有期望的空间关系，以优化一次性的，集成的体外血液回路的灌注和使用。 一个可重复使用的电路支架支持一次性电路支撑模块相对于主要解决方案源，主动排气控制器和其他部件。

    Artificial heart-lung apparatus
    10.
    发明授权
    Artificial heart-lung apparatus 失效
    人造心肺器

    公开(公告)号：US06949220B2

    公开(公告)日：2005-09-27

    申请号：US10702906

    申请日：2003-11-05

    申请人： Yusuke Abe

    发明人： Yusuke Abe

    IPC分类号： A61M1/14 ,  A61M1/10 ,  A61M1/16 ,  A61M1/36

    CPC分类号： A61M1/3666 ,  A61M1/1006 ,  A61M1/1081 ,  A61M1/1698 ,  A61M1/369 ,  Y10S261/28

    摘要： An integrated, artificial heart-lung machine and method for performing extracorporeal blood oxygenation and circulation. The heart-lung machine is a single unit in which a cylindrical artificial lung, preferably with a heat exchanger, is connected in series to an undulation pump and a removable drive unit. The undulation pump is directly connected to the oxygenator which significantly reduces the blood priming volume of the system.

    摘要翻译： 一种综合的人造心肺机和体外血氧循环的方法。 心肺机是一个单一的单元，其中圆柱形人造肺，优选地具有热交换器，与起伏泵和可移除的驱动单元串联连接。 起搏泵直接连接到充氧器，显着降低系统的引流量。