公开(公告)号：US20190192487A1

公开(公告)日：2019-06-27

申请号：US16233280

申请日：2018-12-27

Applicant: Academia Sinica

Inventor： Chinpan CHEN ,  Tien-Sheng TSENG ,  Keng-Chang TSAI

IPC: A61K31/422 ,  A61K45/06 ,  A61K31/385

CPC classification number: A61K31/422 ,  A61K31/385 ,  A61K45/06

Abstract: Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A-L-B-L-A   (I) wherein, A is a moiety having a negative charge; L is —(C2H5—O)n—CH2— or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1; and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.

公开(公告)号：US10329570B2

公开(公告)日：2019-06-25

申请号：US15500354

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Yi-Chung Chang ,  Wei-Yun Lai

IPC: C12N15/11 ,  C12N15/115 ,  A61K31/7088 ,  C12N15/113 ,  A61K31/713 ,  C12N15/117 ,  A61K47/60

Abstract: Aptamers that bind to and antagonize programmed cell death protein 1 (PD-1). Also provided herein are pharmaceutical compositions comprising such anti-PD-1 aptamers and methods for using the same for promoting T cell proliferation, treating cancer or infectious diseases, such as human immunodeficiency virus (HIV) infection.

公开(公告)号：US10317393B2

公开(公告)日：2019-06-11

申请号：US15729317

申请日：2017-10-10

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Tsui-Ling Hsu ,  Sarah R. Hanson ,  Masaaki Sawa

IPC: G01N33/50 ,  G01N33/533

Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

公开(公告)号：US10283714B2

公开(公告)日：2019-05-07

申请号：US15421221

申请日：2017-01-31

Applicant: ACADEMIA SINICA ,  National Taiwan University

Inventor： Kuang-Lieh Lu ,  Muhammad Usman ,  Yang-Fang Chen ,  Golam Haider ,  Shruti Mendiratta ,  Tzuoo-Tsair Luo

IPC: H01L51/54 ,  C09K11/06 ,  H01L51/00 ,  C08G79/00 ,  H01L51/52 ,  H01L51/50

Abstract: An organic electroluminescent material is shown in the following general formula (1), {[M(L)(H2O)x].(H2O)y}n  General Formula (1) wherein x is between 1 and 4, y is between 1 and 8, and n is a positive integer. M is any one selected from the group consisting of beryllium (Be), strontium (Sr), and radium (Ra). L is an organic ligand containing a naphthalene group and an anhydride group. M and L form metal-organic frameworks. An organic electroluminescent device containing the organic electroluminescent material is also disclosed.

公开(公告)号：US10238631B2

公开(公告)日：2019-03-26

申请号：US15316700

申请日：2015-06-05

Applicant: Academia Sinica

Inventor： Lie-Fen Shyur ,  Kuo-Hsiung Lee ,  Kyoko Nakagawa-Goto ,  Jia-Hua Feng ,  Jo-Yu Chen ,  Wai-Leng Lee ,  Yu-Ting Cheng ,  Jing-Ying Huang

IPC: A61K31/365 ,  A61K45/06 ,  A61K31/337 ,  A61K31/437 ,  C07D493/18 ,  A61K31/198 ,  A61K31/655

Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

公开(公告)号：US10214765B2

公开(公告)日：2019-02-26

申请号：US15881581

申请日：2018-01-26

Applicant: Academina Sinica

Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun E. Cheng ,  Chamg-Sheng Tsai

IPC: C07H5/00 ,  C07H13/04 ,  C07H13/12 ,  C12N9/24 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q1/40 ,  C12Q1/70

Abstract: Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.

公开(公告)号：US10213967B2

公开(公告)日：2019-02-26

申请号：US14302243

申请日：2014-06-11

Applicant: ACADEMIA SINICA

Inventor： Keng-Hui Lin ,  Yi-Hsuan Lee

IPC: B29C67/20 ,  B29K77/00 ,  B29K105/00 ,  B29K105/04 ,  B29K105/24

Abstract: A fabricating device of a three-dimensional (3-D) scaffold comprises a bubble generator, a bubble mixing channel, a coagulating solution channel and a bubble collector. The bubble generator includes a gas channel and a gel solution channel crossing the gas channel. The bubble mixing channel is connected with a first outlet of the bubble generator. The coagulating solution channel is connected with the bubble mixing channel. The bubble collector is connected with a second outlet of the bubble mixing channel.

公开(公告)号：US10117890B2

公开(公告)日：2018-11-06

申请号：US15376281

申请日：2016-12-12

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Yun-Lian Lin ,  Jim-Min Fang ,  Yijuang Chern ,  Chia-Ching John Lin ,  Wei-Nan Chen ,  Chun-Jung Lin

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7076 ,  A61K36/8988 ,  A61K45/06

Abstract: Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.

公开(公告)号：US20180299430A1

公开(公告)日：2018-10-18

申请号：US15951114

申请日：2018-04-11

Applicant: Academia Sinica

Inventor： Hung-Chih KUO ,  Ching-Yu CHUANG ,  Chan-Hsien YEH

IPC: G01N33/50

Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.

公开(公告)号：US10087450B2

公开(公告)日：2018-10-02

申请号：US15156998

申请日：2016-05-17

Applicant: Academia Sinica

Inventor： Jui-Jen Chang ,  Wen-Hsiung Li ,  Chieh-Chen Huang ,  Hao-Yeh Lin ,  Ming-Che Shih

IPC: C12N1/15 ,  C12N15/52 ,  C12N15/65 ,  C12N9/42 ,  C12N15/81 ,  A01H5/02

Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).