公开(公告)号：US20210269541A1

公开(公告)日：2021-09-02

申请号：US17172698

申请日：2021-02-10

Applicant: GENMAB A/S ,  BIONTECH SE

Inventor： Isil ALTINTAS ,  David SATIJN ,  Rik RADEMAKER ,  Paul PARREN ,  Ugur SAHIN ,  Friederike GIESEKE ,  Alexander MUIK ,  Christian GRUNWITZ

IPC: C07K16/28

Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.

公开(公告)号：US11091553B2

公开(公告)日：2021-08-17

申请号：US15832337

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart De Goeij ,  Simone De Haij ,  Thilo Riedl ,  Rene Hoet ,  Ole Baadsgaard ,  Jan Van De Winkel ,  David Satijn ,  Paul Parren ,  Aran Frank Labrijn ,  Joyce Meesters ,  Janine Schuurman ,  Edward N. Van Den Brink

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US11084882B2

公开(公告)日：2021-08-10

申请号：US16855703

申请日：2020-04-22

Applicant: GENMAB A/S ,  BioNTech SE

Inventor： Isil Altintas ,  David Satijn ,  Rik Rademaker ,  Paul Parren ,  Friederike Gieseke ,  Ugur Sahin

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/569

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

公开(公告)号：US20210171657A1

公开(公告)日：2021-06-10

申请号：US16880241

申请日：2020-05-21

Applicant: GENMAB A/S

Inventor： Sandra VERPLOEGEN ,  David P.E. SATIJN ,  Rene M.A. HOET ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Vibeke Miller BREINHOLT ,  Eva EHRNROOTH ,  Ole BAADSGAARD, D.M.Sc. ,  Tom VINK ,  Willem Karel BLEEKER ,  Mischa HOUTKAMP ,  Maroeska OUDSHOORN ,  Rob N. DE JONG

IPC: C07K16/36 ,  A61K39/395 ,  A61K39/00

Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20210032358A1

公开(公告)日：2021-02-04

申请号：US16967365

申请日：2019-02-08

Applicant: GENMAB A/S

Inventor： Jesper VALBJOERN ,  Lene Schantz HARLOW ,  Jacob Dahlqvist CLAUSEN ,  Mette Hamborg JENSEN ,  Christian CIMANDER ,  Peter Juul MADSEN

IPC: C07K16/28 ,  A61K9/00 ,  A61K47/12 ,  A61K47/26

Abstract: The present invention relates to pharmaceutical compositions and dosage unit forms of bispecific CD3xCD20 antibodies and to routes of administration.

公开(公告)号：US20210030888A1

公开(公告)日：2021-02-04

申请号：US16978539

申请日：2019-03-06

Applicant: Genmab A/S

Inventor： Reshma Abdulla RANGWALA ,  Esther Cornelia Wilhelmina BREIJ ,  David SATIJN ,  Sandra VERPLOEGEN ,  Jantine BAKEMA ,  Oyewale O. ABIDOYE ,  Leonardo Viana NICACIO ,  Andreas LINGNAU

IPC: A61K47/68 ,  C07K16/36 ,  A61K9/00 ,  A61P35/00

Abstract: The invention provides methods and compositions for treating cancer, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer).

公开(公告)号：US10752695B2

公开(公告)日：2020-08-25

申请号：US15197496

申请日：2016-06-29

Applicant: GENMAB A/S

Inventor： Jan Van De Winkel ,  Tom Vink ,  Janine Schuurman ,  Paul Parren ,  Rob Aalberse ,  Marijn Van Der Neut Kolfschoten

IPC: C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  A61K51/10 ,  A61K47/68 ,  C07K16/16 ,  C07K16/18 ,  C07K1/00 ,  A61K39/00

Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

公开(公告)号：US10703818B2

公开(公告)日：2020-07-07

申请号：US15420824

申请日：2017-01-31

Applicant: GENMAB A/S

Inventor： Janine Schuurman ,  Catharina Emanuele Gerarda Havenith ,  Paul Parren ,  Jan G. J. Van De Winkel ,  Denise Leah Williams ,  Jørgen Petersen ,  Ole Baadsgaard

IPC: C07K16/20 ,  C07K16/30 ,  C07K16/40 ,  C07K16/28 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61N5/06 ,  C07K16/42 ,  C07K16/46 ,  G01N33/574 ,  G01N33/569 ,  A61K39/00

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US10590206B2

公开(公告)日：2020-03-17

申请号：US14760157

申请日：2014-01-09

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce Meesters ,  Joost J. Neijssen ,  Edward Norbert Van Den Brink ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/00 ,  C07K16/32 ,  C07K16/12 ,  A61K39/00

Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.

公开(公告)号：US10344050B2

公开(公告)日：2019-07-09

申请号：US14353962

申请日：2012-10-26

Applicant: GENMAB A/S

Inventor： Michael Gramer ,  Amitava Kundu ,  Ewald T. J. Van Den Bremer ,  Muriel Van Kampen ,  Patrick Priem ,  Aran Frank Labrijn ,  Joyce I. Meesters ,  Joost J. Neijssen ,  Janine Schuurman ,  Paul Parren ,  Patrick Van Berkel ,  Werner L. Vos ,  Arnout Gerritsen

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/46 ,  C07K1/113

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.