公开(公告)号：US20130110127A1

公开(公告)日：2013-05-02

申请号：US13352005

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

IPC分类号： A61N1/05 ,  A61B19/00

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/36521 ,  A61N1/37288 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

公开(公告)号：US08321020B1

公开(公告)日：2012-11-27

申请号：US11549494

申请日：2006-10-13

申请人： Gene A. Bornzin ,  Peter Boileau ,  Jeffery D. Snell

发明人： Gene A. Bornzin ,  Peter Boileau ,  Jeffery D. Snell

IPC分类号： A61N1/362

CPC分类号： A61N1/3624 ,  A61N1/3704 ,  A61N1/371

摘要： A method for operating an implantable medical device includes delivering a plurality of pacing pulses to an atria of a patient's heart and monitoring intrinsic atrial activity to detect intrinsic atrial contractions between one or more of the plurality of pacing pulses. The method further includes detecting atrial undersensing as a function of the detection of intrinsic atrial contractions.

摘要翻译： 一种用于操作可植入医疗装置的方法包括将多个起搏脉冲输送到患者心脏的心房并监测内在心房活动以检测多个起搏脉冲中的一个或多个之间的固有心房收缩。 该方法还包括检测心房不足，作为内在心房收缩的检测的函数。

公开(公告)号：US08306623B2

公开(公告)日：2012-11-06

申请号：US13149507

申请日：2011-05-31

申请人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

发明人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

IPC分类号： A61N1/18

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

摘要翻译： 可植入系统采用可植入引线系统获得心内阻抗。 在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。 当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。 所施加的脉冲的影响被感测为对应的波形。 施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。 可以比较这些区域以获得组织的可靠的阻抗值。 还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

公开(公告)号：US08170664B1

公开(公告)日：2012-05-01

申请号：US11931165

申请日：2007-10-31

申请人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

发明人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

IPC分类号： A61N1/37 ,  A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.

摘要翻译： 本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。 确定斜率，其中斜率表示在一段时间内生理特性的变化。 基于斜率的大小来监测心脏病。 在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。 根据斜率的变化监测患者心脏病变化。

公开(公告)号：US08150512B2

公开(公告)日：2012-04-03

申请号：US12273286

申请日：2008-11-18

申请人： Gene A. Bornzin ,  Peter Boileau ,  John W. Poore

发明人： Gene A. Bornzin ,  Peter Boileau ,  John W. Poore

IPC分类号： A61N1/00

CPC分类号： A61N1/36521 ,  A61N1/3706

摘要： A process for determining whether the location of a stimulation electrode meets a selected heart performance criteria includes providing stimulation to the heart through the electrode and obtaining an impedance measurement during stimulation delivery using an impedance sensing vector formed by electrodes that do not include the stimulation electrode. The impedance measurements are processed, either alone or in combination with an electrogram, also obtained during stimulation, to obtain a measure of hemodynamic performance.

摘要翻译： 用于确定刺激电极的位置是否满足所选择的心脏性能标准的过程包括通过电极向心脏提供刺激，并且使用由不包括刺激电极的电极形成的阻抗感测向量在刺激递送期间获得阻抗测量。 阻抗测量单独地或与刺激期间获得的电描绘图结合进行处理，以获得血液动力学性能的量度。

公开(公告)号：US08135464B1

公开(公告)日：2012-03-13

申请号：US11830499

申请日：2007-07-30

申请人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

发明人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

IPC分类号： A61N1/362

CPC分类号： A61N1/3624

摘要： In various embodiments of the present invention, lower amplitude high frequency burst stimulation of cardiac fat pad(s) innervating the AV node and/or ventricle tissue performed in conjunction with ventricular pacing during refractory period is used to reduce the ventricular rate in order to terminate arrhythmias such as supraventricular tachycardia. In an embodiment of the present invention, one or more pace pulse delivered during a ventricular refractory period can be used to further extend the duration of the refractory period followed by a short burst of cardiac fat pad stimulation to temporarily slow AV conduction. In an embodiment of the present invention, this therapy slows the ventricular rate by altering conduction speed in both the AV node and the ventricles.

摘要翻译： 在本发明的各种实施例中，使用在不稳定期间结合心室起搏执行支配AV结节和/或心室组织的心脏脂肪垫的较低振幅高频爆发刺激来降低心室率以终止 心律失常如室上性心动过速。 在本发明的一个实施方案中，可以使用在心室不应期期间递送的一个或多个步速脉冲来进一步延长不应期的持续时间，随后是心脏脂肪垫刺激的短暂爆发以暂时缓慢AV传导。 在本发明的一个实施方案中，该疗法通过改变AV节点和心室中的传导速度来减慢心室率。

公开(公告)号：US08126550B2

公开(公告)日：2012-02-28

申请号：US12177405

申请日：2008-07-22

申请人： George E. Eisinger ,  Jeffery D. Snell ,  Gene A. Bornzin

发明人： George E. Eisinger ,  Jeffery D. Snell ,  Gene A. Bornzin

IPC分类号： A61N1/18

CPC分类号： A61N1/3704 ,  A61N1/3622

摘要： During a period of time comprising a plurality of cardiac cycles, a time relationship between ventricular events and atrial detections is established. Based on the relationship, a post-ventricular atrial refractory period is defined. The period includes an absolute atrial refractory period and a segmented relative atrial refractory period, wherein the segmented relative atrial refractory period includes at least one blanking window during which atrial detections of ventricular events have or are likely to occur.

摘要翻译： 在包括多个心动周期的时间段期间，建立了心室事件与心房检测之间的时间关系。 根据关系，定义了心室后不应期。 该期间包括绝对心房不应期和分段的相对心房不应期，其中所述分段的相对心房不应期包括至少一个消融窗口，在此期间心房事件已经或可能发生。

公开(公告)号：US08090435B2

公开(公告)日：2012-01-03

申请号：US12360826

申请日：2009-01-27

申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

IPC分类号： A61B5/0402

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

公开(公告)号：US20110282226A1

公开(公告)日：2011-11-17

申请号：US12820879

申请日：2010-06-22

申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

IPC分类号： A61B5/04

CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

公开(公告)号：US08019410B1

公开(公告)日：2011-09-13

申请号：US11843480

申请日：2007-08-22

申请人： Rupinder Bharmi ,  Gene A. Bornzin ,  Brian Jeffrey Wenzel

发明人： Rupinder Bharmi ,  Gene A. Bornzin ,  Brian Jeffrey Wenzel

IPC分类号： A61B5/0205 ,  A61B5/0452

CPC分类号： A61B5/0205 ,  A61B5/0472 ,  A61B5/721

摘要： An intracardiac electrogram (IEGM) or other suitable electrical cardiac signal is sensed. Values representative of a pre-symptomatic physiologic response to a hypoglycemic event are derived from the cardiac signal. Then, hypoglycemia is detected based on the values representative of the pre-symptomatic physiologic response. In one example, both temporal morphological parameters and spectral parameters affected by pre-symptomatic hypoglycemia are derived from the cardiac signal. Hypoglycemia is then detected based on a combination of the temporal and spectral parameters using, e.g., a linear discriminator. By detecting hypoglycemia based on parameters affected by pre-symptomatic hypoglycemia, suitable warnings can be generated and therapies initiated before the condition becomes symptomatic.

摘要翻译： 感测到心内电描记图（IEGM）或其他合适的心电信号。 代表低血糖事件的症状性生理反应的值代表心脏信号。 然后，根据代表症状前生理反应的值检测低血糖。 在一个实例中，由症状性低血糖影响的时间形态学参数和光谱参数均来自心脏信号。 然后使用例如线性鉴别器基于时间和频谱参数的组合检测低血糖。 通过根据受症状性低血糖影响的参数检测低血糖，可以产生合适的警告，并在症状发作前进行治疗。