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    Monitoring heart disease using implantable sensors and slopes determined therefrom
    2.
    发明授权
    Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
    使用由其确定的可植入传感器和斜坡来监测心脏病

    公开(公告)号：US08170664B1

    公开(公告)日：2012-05-01

    申请号：US11931165

    申请日：2007-10-31

    申请人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/37 ,  A61N1/08

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.

    摘要翻译： 本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。 确定斜率，其中斜率表示在一段时间内生理特性的变化。 基于斜率的大小来监测心脏病。 在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。 根据斜率的变化监测患者心脏病变化。

    Painless ventricular rate control during supraventricular tachycardia
    3.
    发明授权
    Painless ventricular rate control during supraventricular tachycardia 有权
    室上性心动过速期间无痛心室率控制

    公开(公告)号：US08135464B1

    公开(公告)日：2012-03-13

    申请号：US11830499

    申请日：2007-07-30

    申请人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3624

    摘要： In various embodiments of the present invention, lower amplitude high frequency burst stimulation of cardiac fat pad(s) innervating the AV node and/or ventricle tissue performed in conjunction with ventricular pacing during refractory period is used to reduce the ventricular rate in order to terminate arrhythmias such as supraventricular tachycardia. In an embodiment of the present invention, one or more pace pulse delivered during a ventricular refractory period can be used to further extend the duration of the refractory period followed by a short burst of cardiac fat pad stimulation to temporarily slow AV conduction. In an embodiment of the present invention, this therapy slows the ventricular rate by altering conduction speed in both the AV node and the ventricles.

    摘要翻译： 在本发明的各种实施例中，使用在不稳定期间结合心室起搏执行支配AV结节和/或心室组织的心脏脂肪垫的较低振幅高频爆发刺激来降低心室率以终止 心律失常如室上性心动过速。 在本发明的一个实施方案中，可以使用在心室不应期期间递送的一个或多个步速脉冲来进一步延长不应期的持续时间，随后是心脏脂肪垫刺激的短暂爆发以暂时缓慢AV传导。 在本发明的一个实施方案中，该疗法通过改变AV节点和心室中的传导速度来减慢心室率。

    Processing venous oxygen saturation and hematocrit information in an implantable sensor
    7.
    发明授权
    Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
    在植入式传感器中处理静脉血氧饱和度和血细胞比容信息

    公开(公告)号：US08385999B1

    公开(公告)日：2013-02-26

    申请号：US12028261

    申请日：2008-02-08

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    IPC分类号： A61B5/00

    CPC分类号： A61N1/39 ,  A61B5/0031 ,  A61B5/14535 ,  A61B5/14551 ,  A61B5/4836 ,  A61N1/362

    摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.

    摘要翻译： 提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。 在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。 该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。 对光检测器的输出进行采样以测量透射光的强度。 对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

    BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS
    8.
    发明申请
    BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
    用于可植入器件应用的BIOELECTRIC BATTERY

    公开(公告)号：US20110202105A1

    公开(公告)日：2011-08-18

    申请号：US13018140

    申请日：2011-01-31

    申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

    发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/362 ,  H01M8/16

    CPC分类号： A61N1/378 ,  H01M2/0275 ,  H01M2/1066 ,  H01M2/1653 ,  H01M2/18 ,  H01M2/361 ,  H01M4/12 ,  H01M4/366 ,  H01M4/48

    摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.

    摘要翻译： 生物电池可用于为可植入装置供电。 生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得 管为阴极提供支撑。 生物电池还可以具有围绕阴极的膜以减少组织包封。 或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。 电解质设置在可渗透膜内，并且网围绕可渗透膜。 在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

    Systems and methods for increasing implantable sensor accuracy
    10.
    发明授权
    Systems and methods for increasing implantable sensor accuracy 有权
    增加植入式传感器精度的系统和方法

    公开(公告)号：US07920913B1

    公开(公告)日：2011-04-05

    申请号：US11771514

    申请日：2007-06-29

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi

    IPC分类号： A61B5/04

    CPC分类号： A61B5/14551 ,  A61B2560/02

    摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.

    摘要翻译： 本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。 根据系统的具体实施例，获得推测为准确的测量值。 测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。 另外，植入用于产生生理特性的多个测量。 将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。 此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。