公开(公告)号：US20240091248A1

公开(公告)日：2024-03-21

申请号：US18501909

申请日：2023-11-03

Applicant: GENENTECH, INC. ,  ABBVIE INC.

Inventor： Ahmed Hamed SALEM ,  Jalaja POTLURI ,  Jiuhong ZHA ,  Mehrdad MOBASHER ,  Wan-Jen HONG

IPC: A61K31/706 ,  A61K9/00 ,  A61K31/635 ,  A61P35/02

CPC classification number: A61K31/706 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/635 ,  A61P35/02

Abstract: Provided herein are methods for treating acute myeloid leukemia (AML) in a patient with cytopenia when on a combination therapy of venetoclax and azacitidine. Also provided herein are methods of managing a cytopenia in such patient.

公开(公告)号：US20240087726A1

公开(公告)日：2024-03-14

申请号：US18506905

申请日：2023-11-10

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc. ,  Ventana Medical Systems, Inc.

Inventor： Paolo Santiago Syjuco OCAMPO ,  Bernhard STIMPEL ,  Yao NIE ,  Fahime SHEIKHZADEH ,  Xiao LI ,  Przemyslaw SZOSTAK ,  Prasanna PORWAL ,  Faranak AGHAEI

IPC: G16H30/40 ,  G06T7/00 ,  G16H20/00 ,  G16H50/20

CPC classification number: G16H30/40 ,  G06T7/0012 ,  G16H20/00 ,  G16H50/20

Abstract: A method includes accessing a digital pathology image that depicts tumor cells sampled from a subject. A plurality of patches may be selected from the digital pathology image, wherein each of the patches depicts tumor cells. A mutation prediction may be generated for each of the patches, wherein the mutation prediction represents a prediction of a likelihood that an actionable mutation appears in the patch. Based on the plurality of mutation predictions, a prognostic prediction related to one or more treatment regimens for the subject may be generated. The prognostic prediction may be based on determining one or more mutational contexts of the digital pathology image as an unknown driver or a tumor suppressor, an oncogene driver mutation, or a gene fusion.

公开(公告)号：US20240084391A1

公开(公告)日：2024-03-14

申请号：US18237959

申请日：2023-08-25

Applicant: Genentech, Inc.

Inventor： Milena Rosa Hornburg ,  Yulei Wang

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57449 ,  C12Q2600/158 ,  G01N2800/52

Abstract: This application discloses methods of designing a treatment protocol for a human patient with ovarian cancer, as well as methods of treatment of ovarian cancer. This application also includes methods of characterizing an ovarian cancer in a human patient by the type of tumor.

公开(公告)号：US20240084375A1

公开(公告)日：2024-03-14

申请号：US18495615

申请日：2023-10-26

Applicant: Genentech, Inc.

Inventor： Christian N. Cunningham ,  Kenneth Karl Hallenbeck

IPC: C12Q1/686 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/1805

Abstract: In one embodiment, a method and system normalize a polymerase chain reaction (PCR) amplification process for a plurality of samples containing DNA. Cycle data for performing the PCR amplification process is identified for the plurality of samples. The cycle data includes a corresponding cycle count for each sample of the plurality of samples. The plurality of samples is sorted into a plurality of bins based on the cycle data such that cycle count variation between bins of the plurality of bins is reduced. A bin cycle count is assigned to each bin of the plurality of bins. The bin cycle count is unique to each bin of the plurality of bins. Identification information is generated for the bins. An output for performing a PCR amplification of the plurality of samples is generated using the bins and the bin cycle count for each bin of the plurality of bins.

公开(公告)号：US20240084240A1

公开(公告)日：2024-03-14

申请号：US18464131

申请日：2023-09-08

Applicant: GENENTECH, INC.

Inventor： Arthi NARAYANAN ,  Aditya Avdhut WALVEKAR ,  Georo L. ZHOU ,  Nicholas RUMMEL ,  Zheng LI ,  Steven J. MEIER

IPC: C12M1/36 ,  G06N3/08

CPC classification number: C12M41/48 ,  G06N3/08

Abstract: A method, system, and non-transitory computer readable medium for predicting cell viability of a cell culture in a bioreactor during a biomolecule manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing molecules are input into a machine learning model that is trained to predict cell viabilities. The trained machine learning model may then analyze the at least three manufacturing process parameters to generate an indicator of cell viability of the cell culture.

公开(公告)号：US20240079138A1

公开(公告)日：2024-03-07

申请号：US18139873

申请日：2023-04-26

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc. ,  Ventana Medical Systems, Inc.

Inventor： Yao NIE ,  Xiao LI ,  Trung Kien NGUYEN ,  Fabien GAIRE ,  Eldad KLAIMAN ,  Ido BEN-SHAUL ,  Jacob GILDENBLAT ,  Ofir Etz HADAR

IPC: G16H50/20 ,  G06T7/00 ,  G16H30/40

CPC classification number: G16H50/20 ,  G06T7/0012 ,  G16H30/40 ,  G06T2207/20084

Abstract: Systems and methods relate to predicting disease progression by processing digital pathology images using neural networks. A digital pathology image that depicts a specimen stained with one or more stains is accessed. The specimen may have been collected from a subject. A set of patches are defined for the digital pathology image. Each patch of the set of patches depicts a portion of the digital pathology image. For each patch of the set of patches and using an attention-score neural network, an attention score is generated. The attention-score neural network may have been trained using a loss function that penalized attention-score variability across patches in training digital pathology images labeled to indicate no or low subsequent disease progression. Using a result-prediction neural network and the attention scores, a result is generated that represents a prediction of whether or an extent to which a disease of the subject will progress.

公开(公告)号：US20240076358A1

公开(公告)日：2024-03-07

申请号：US18165142

申请日：2023-02-06

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06 ,  A61P25/28 ,  C07K16/00

CPC classification number: C07K16/18 ,  A61K9/0019 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/28 ,  C07K16/00 ,  A61K2039/505

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20240074652A1

公开(公告)日：2024-03-07

申请号：US18139870

申请日：2023-04-26

Applicant: Genentech, Inc.

Inventor： Michael BARTLETT ,  Yi-Zhong WANG

IPC: A61B3/032 ,  A61B3/00 ,  A61B3/11

CPC classification number: A61B3/032 ,  A61B3/0025 ,  A61B3/0033 ,  A61B3/0041 ,  A61B3/0058 ,  A61B3/111 ,  A61B3/1225

Abstract: In an embodiment of the disclosure, there is provided a handheld vision tester for vision self-testing by a user. The handheld vision tester comprises a touchscreen display, a control, and an interface port. The touchscreen display is configured to present different shapes, either statically or dynamically, to the user for the vision self-testing. One of the different shapes may be a modulated version of another similar shape displayed at the same time and includes a modulated edge. The control is configured to allow a user to trigger operations of the tester and allow the user to select one of the different shapes. The handheld vision tester is configured to determine results of the vision self-testing from the user selections and store the results in the handheld vision tester. The interface port is configured to transmit the stored results to a healthcare provider who uses the results to enhance treatment routines.

公开(公告)号：US20240060135A1

公开(公告)日：2024-02-22

申请号：US17937102

申请日：2022-09-30

Applicant: Genentech, Inc.

Inventor： Li-Fen LIU ,  Sanjeev MARIATHASAN ,  Chi Yung YUEN ,  Mahrukh HUSENI

IPC: C12Q1/6886 ,  A61P35/00 ,  C07K16/28 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  A61P35/00 ,  C07K16/2827 ,  G01N33/57484 ,  C07K2317/24 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2333/5421

Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer (e.g., bladder cancer (e.g., UC) or kidney cancer (e.g., RCC)). The invention provides methods of identifying an individual having a cancer who is likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, methods for selecting a therapy for an individual having a cancer, methods of identifying an individual having a cancer who is less likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist monotherapy, methods of monitoring the response of an individual having a cancer to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, and methods of treating an individual having cancer, based on expression levels of a biomarker of the invention (e.g., one or more genes set forth in any one of Tables 1-7, e.g., IL8).

公开(公告)号：US11897864B2

公开(公告)日：2024-02-13

申请号：US17938835

申请日：2022-10-07

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  C07D471/04 ,  C07D209/82 ,  C07D403/12 ,  A61K31/496

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/30

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.