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    COMPUTER-IMPLEMENTED METHODS AND SYSTEMS FOR QUANTITATIVELY DETERMINING A CLINICAL PARAMETER
    71.
    发明公开
    COMPUTER-IMPLEMENTED METHODS AND SYSTEMS FOR QUANTITATIVELY DETERMINING A CLINICAL PARAMETER 审中-公开

    公开(公告)号：US20240153632A1

    公开(公告)日：2024-05-09

    申请号：US18282505

    申请日：2022-03-30

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Marco GANZETTI

    IPC: G16H50/20 ,  A61B5/00 ,  A61B5/11 ,  G06N20/00

    CPC classification number: G16H50/20 ,  A61B5/1127 ,  A61B5/4082 ,  A61B5/4566 ,  A61B5/4842 ,  A61B5/7435 ,  G06N20/00 ,  A61B2560/0437

    Abstract: A computer-implemented method for quantitatively determining a clinical parameter indicative of a status or progression of a disease comprises the steps of: providing a distal motor test to a user of a mobile device, the mobile device having a touchscreen display, wherein providing the distal motor test to the user of the mobile device comprises: causing the touchscreen display of the mobile device to display an image comprising: a reference start point, a reference end point, and indication of a reference path to be traced between the start point and the end point; receiving an input from the touchscreen display of the mobile device, the input indicative of a test path traced by a user attempting to trace the reference path on the display of the mobile device, the test path comprising: a test start point, a test end point, and a test path traced between the test start point and the test end point; and extracting digital biomarker feature data from the received input, the digital biomarker feature data comprising: a deviation between the test end point and the reference end point; a deviation between the test start point and the reference start point; and/or a deviation between the test start point and the reference end point; and wherein: the extracted digital biomarker feature data is the clinical parameter; or the method further comprises calculating the clinical parameter from the extracted biomarker feature data.

    Droplet dispensing device and system
    73.
    发明授权
    Droplet dispensing device and system 有权

    公开(公告)号：US11951036B2

    公开(公告)日：2024-04-09

    申请号：US16760289

    申请日：2018-11-02

    Applicant: HOFFMANN-LA ROCHE INC.

    Inventor： Maxime Gaillot ,  Roberta Leah ,  Declan Reilly ,  Thomas Thueer ,  Jack Carroll ,  James Coop ,  Edward Sims ,  Mark Teucher

    IPC: A61F9/00

    CPC classification number: A61F9/0008

    Abstract: A device for providing a droplet of a liquid stored in an interior of a vial is disclosed that includes a support body and a resilient dome portion mounted to the support body to form a chamber having air, with the dome portion being configured to create an air flow when activated by compression. The support body includes a vial seat, a nozzle, and air flow and transfer conduits. The support body is arranged, when the vial is received by the vial seat, such that the air flow conduit establishes an air connection between the vial interior and the chamber, the transfer conduit establishes a fluid connection between the vial and the nozzle, and, upon activation of the dome portion, the air flow delivers air into the vial that causes liquid to be transferred from the vial to the nozzle through the transfer conduit.

    Device for use in the detection of binding affinities
    74.
    发明授权
    Device for use in the detection of binding affinities 有权

    公开(公告)号：US11946930B2

    公开(公告)日：2024-04-02

    申请号：US15733485

    申请日：2019-02-28

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Christof Fattinger

    IPC: G01N21/47 ,  G01N21/77 ,  G01N33/543

    CPC classification number: G01N33/54373 ,  G01N21/4788 ,  G01N21/7743

    Abstract: A device for use in the detection of binding affinities comprises a substrate, a planar waveguide arranged thereon and having an outer surface. The device further comprises a grating for coupling coherent light of a predetermined wavelength into the planar waveguide such that the coherent light coupled into the planar waveguide propagates through the planar waveguide in a predetermined propagation direction. An evanescent field of the coherent light propagates along the outer surface of the planar waveguide. The outer surface of the planar waveguide has receptor molecules arranged thereon capable of binding target samples to the receptor molecules such that light of the evanescent field is diffracted by the target samples bound to the receptor molecules. The receptor molecules are arranged along a plurality of straight parallel lines such that a portion of the light of the evanescent field is diffracted by the target samples bound to the receptor molecules.

    IMMUNOASSAY-BASED DETERMINATION OF IN-SOLUTION BINDING KINETICS
    76.
    发明公开
    IMMUNOASSAY-BASED DETERMINATION OF IN-SOLUTION BINDING KINETICS 审中-公开

    公开(公告)号：US20240102999A1

    公开(公告)日：2024-03-28

    申请号：US18523859

    申请日：2023-11-29

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Uwe DAHL ,  Gregor JORDAN ,  Roland STAACK

    IPC: G01N33/557 ,  G01N33/15

    CPC classification number: G01N33/557 ,  G01N33/15

    Abstract: Herein is reported a method for the determination of the binding affinity of a binder and its ligand comprising the step of determining based on the result of an immunoassay the fraction of free binder in a sample comprising binder, ligand and binder-ligand-complexes for at least two different binder:ligand ratios in the sample, and if the determined fraction of free binder is not comparable for all used binder:ligand ratios then the binder:ligand ratio in the sample is lowered and the sample is re-analyzed by the same immunoassay, and calculating based on the fraction of free binder in the previous step the binding affinity for the binder to its ligand.

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