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公开(公告)号：US11780919B2
公开(公告)日：2023-10-10
申请号：US17218948
申请日：2021-03-31
发明人： Maria Amann , Juergen Peter Bachl , Alexander Bujotzek , Carina Cantrill , Harald Duerr , Janine Faigle , Sabine Imhof-Jung , Christian Klein , Thomas Kraft , Estelle Marrer-Berger , Ekkehard Moessner , Laurene Pousse , Petra Rueger , Johannes Sam , Roland Staack , Dietrich Tuerck , Pablo Umana , Joerg Zielonka
CPC分类号： C07K16/2809 , A61K45/06 , A61P35/00 , C07K16/2878 , C07K16/30 , C07K16/468 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US11603411B2
公开(公告)日：2023-03-14
申请号：US15941524
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11440942B2
公开(公告)日：2022-09-13
申请号：US16354627
申请日：2019-03-15
摘要： Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
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公开(公告)号：US20210301030A1
公开(公告)日：2021-09-30
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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5.发明授权公开(公告)号：US10011644B2
公开(公告)日：2018-07-03
申请号：US14611645
申请日：2015-02-02
发明人： Petra Rueger , Tilman Schlothauer , Stefan Seeber
IPC分类号： C07K14/705 , G01N33/68 , C07K14/735
CPC分类号： C07K14/705 , C07K14/70535 , C07K2319/30 , G01N33/6854 , G01N2333/70535
摘要： Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes a heavy chain Fc-region polypeptide, wherein R1 or R2 or both are present, wherein FC does not substantially bind to R1 and/or R2 and uses thereof.
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公开(公告)号：US11814409B2
公开(公告)日：2023-11-14
申请号：US16258294
申请日：2019-01-25
IPC分类号： C07K1/22 , B01D15/16 , B01D15/38 , B01J20/289 , B01J20/32 , C07K16/06 , C07K16/28 , B01J39/26 , G01N33/68
CPC分类号： C07K1/22 , B01D15/168 , B01D15/3809 , B01J20/289 , B01J20/3204 , B01J20/3206 , B01J20/3219 , B01J20/3274 , B01J39/26 , C07K16/065 , C07K16/2866 , G01N33/6854
摘要： Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.
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7.发明申请公开(公告)号：US20200369719A1
公开(公告)日：2020-11-26
申请号：US16955776
申请日：2018-12-20
摘要： The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydrophobic interaction chromatography.
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8.发明申请公开(公告)号：US20180265564A1
公开(公告)日：2018-09-20
申请号：US15996846
申请日：2018-06-04
发明人： Petra Rueger , Tilman Schlothauer , Stefan Seeber
IPC分类号： C07K14/705 , G01N33/68 , C07K14/735
摘要： Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes a heavy chain Fc-region polypeptide, wherein R1 or R2 or both are present, wherein FC does not substantially bind to R1 and/or R2 and uses thereof.
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公开(公告)号：US20180222992A1
公开(公告)日：2018-08-09
申请号：US15941655
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61K2039/505 , A61P25/28 , C07K16/18 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20150018241A1
公开(公告)日：2015-01-15
申请号：US14378808
申请日：2013-02-14
CPC分类号： C07K1/22 , B01D15/168 , B01D15/3809 , B01J20/289 , B01J20/3204 , B01J20/3206 , B01J20/3219 , B01J20/3274 , B01J39/26 , C07K16/065 , C07K16/2866 , G01N33/6854
摘要： Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.
摘要翻译： 本文报道了通常使用新生儿Fc受体（FcRn）和β-2-微球蛋白（b2m）的固定化非共价复合物作为亲和层析配体，并且例如用于测定体内半活 通过测定抗体与参考抗体的保留时间的比例来测定抗体。
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