公开(公告)号：US09884046B1

公开(公告)日：2018-02-06

申请号：US15632406

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun Yao ,  Lai Han Elaine Leung ,  Liang Liu ,  Xing Xing Fan ,  Chun Xie

IPC: A61K31/428 ,  C07D277/72 ,  G01N33/574 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K31/428 ,  A61K38/00 ,  C07D277/72 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/68

Abstract: One embodiment relates to a method of treating lung cancer by administering a compound of formula I to a patient. Another embodiment relates to a method of treating cancer with a KRAS mutation that includes administering to a patient the compound with the following formula I:

公开(公告)号：US09855250B1

公开(公告)日：2018-01-02

申请号：US15351419

申请日：2016-11-14

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Elaine Lai-Han Leung ,  Xiao-Jun Yao ,  Vincent Kam-Wai Wong ,  Xi Chen

IPC: A61K31/4245

CPC classification number: A61K31/4245

Abstract: One example embodiment relates to a method of treating lung cancer by administering a compound of formula I to a subject in need thereof. Another embodiment relates to a method to treat Non-Small Cell Lung Cancer (NSCLC) by administering the compound of formula I to a patient.

公开(公告)号：US20170339702A1

公开(公告)日：2017-11-23

申请号：US15160014

申请日：2016-05-20

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Yuan Wu ,  Haohan Chai ,  Liping Qian ,  Weidang Lu ,  ChangSheng Yu

IPC: H04W72/08 ,  H04W28/10 ,  H04W28/02

CPC classification number: H04W28/0236 ,  H04W28/10

Abstract: A communication system and a method for transmitting data over a communication network includes a processing module arranged for selectively splitting a traffic demand of a transmission link into a plurality of portions of traffic demands distributed over a main channel and at least one auxiliary channel of the communication network, and the processing module is further arranged to determine a data transmission relationship associated with the traffic demand of the transmission link and at least one parameter of both the main channel and the at least one auxiliary channel; and a transmission module arranged to transmit data over one or more of the main channel and the at least one auxiliary channel according to the data transmission relationship.

公开(公告)号：US09782401B1

公开(公告)日：2017-10-10

申请号：US15142373

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K36/24 ,  A61K31/4745

CPC classification number: A61K31/4745 ,  A61K36/24

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

公开(公告)号：US09743309B2

公开(公告)日：2017-08-22

申请号：US14945306

申请日：2015-11-18

Applicant: Macau University of Science and Technology

Inventor： Li Feng

IPC: H04W28/02 ,  H04W74/08 ,  H04L12/54 ,  H04L1/18 ,  H04L12/911

CPC classification number: H04W28/021 ,  H04L1/1854 ,  H04L47/70 ,  H04W74/08 ,  H04W74/0816

Abstract: In widely deployed wireless “hot-spot” networks, nodes frequently join or leave, inelastic/elastic and saturated/non-satuarted flows coexist. In such dynamic and diverse environments, it is challenging to maximize the channel utilization while providing satisfactory user experiences. In this invention, one proposes a novel contention-on-demand (CoD) MAC scheme to address this problem. The CoD scheme consists of a fixed-CW algorithm, a dynamic-CW algorithm, and an admission control unit. The fixed-CW algorithm allows elastic flows to access limited system bandwidth; the dynamic-CW algorithm enables inelastic flows to contend for channel on demand and quickly adapt to network change; and the admission control unit rejects overloaded traffic for providing good user experiences. One then performs an asymptotic analysis to develop a simple but efficient admission control rule. Finally, extensive simulations verify that the scheme is very effective and the theoretical result is very accurate.

公开(公告)号：US20170163538A1

公开(公告)日：2017-06-08

申请号：US14972062

申请日：2015-12-16

Applicant: Macau University of Science and Technology

Inventor： Li Feng ,  Liang Zhou ,  Zhijun Xu ,  Yujun Zhang

IPC: H04L12/803 ,  H04L12/851 ,  H04L12/707 ,  H04L29/06

CPC classification number: H04L47/125 ,  H04L45/24 ,  H04L47/2483 ,  H04L69/22

Abstract: Compute-intensive packet processing (CIPP) in a computer system comprising a programmable computing platform is accelerated by using a packet I/O engine, implemented on the platform, to perform packet I/O functions, where the packet I/O engine is configured to achieve direct access to a network interface card (NIC) from a user application. For a Linux-based computer system, standard I/O mechanisms of Linux are bypassed and only the packet I/O engine is used in performing the I/O functions. Furthermore, the computer system is configured to: process a batch of packets, instead of packet by packet, in every function call; and when moving a packet between a buffer of an individual user application and a queue of the packet I/O engine, copy a packet descriptor of the packet instead the entire packet. In addition, workflows across different working threads are balanced and parallelism is exploited to fully utilize resources of the platform.

公开(公告)号：US20170095443A1

公开(公告)日：2017-04-06

申请号：US14872198

申请日：2015-10-01

Applicant: Macau University of Science and Technology

Inventor： Pei Luo

IPC: A61K31/357 ,  A61K36/28 ,  A61K31/216

CPC classification number: A61K31/357 ,  A61K31/216 ,  A61K36/28 ,  A61K2300/00

Abstract: A caffeoylquinic acid-rich extract obtained from Erigeron multiradiatus and a method for producing the same. A caffeoylquinic acid-rich extract includes at least 15% by weight of a mixture of certain caffeoylquinic acids. The extract with the mixture of caffeoylquinic acids is highly efficacious in treating and preventing myocardial ischemia or myocardial ischemia reperfusion injuries. A method for treating or preventing a disease caused by myocardial ischemia or myocardial ischemia reperfusion includes administering a therapeutically effective amount of the caffeoylquinic acid-rich extract to a subject. Pharmaceutical compositions including the caffeoylquinic acid-rich extract are also disclosed.

公开(公告)号：US20170083010A1

公开(公告)日：2017-03-23

申请号：US14918564

申请日：2015-10-21

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Qinghua Zhu ,  Mengchu Zhou ,  Yan Qiao

IPC: G05B19/418

CPC classification number: G05B19/41865 ,  G05B2219/34418 ,  G05B2219/45031 ,  G05B2219/50391 ,  Y10S901/02 ,  Y10S901/30

Abstract: Recent trends of larger wafer and smaller lot sizes bring cluster tools with frequent lot switches. Practitioners must deal with more transient processes during such switches, including start-up and close-down processes. To obtain higher yield, it is necessary to shorten the duration of transient processes. Much prior effort was poured into the modeling and scheduling for the steady state of cluster tools. In the existing literature, no attention has been turned to optimize the close-down process for single-arm cluster tools with wafer residency constraints. This invention intends to do so by 1) developing a Petri net model to analyze their scheduling properties and 2) proposing Petri net-based methods to solve their close-down optimal scheduling problems under different workloads among their process steps. Industrial examples are used to illustrate the effectiveness and application of the proposed methods.

公开(公告)号：US20170056390A1

公开(公告)日：2017-03-02

申请号：US14925962

申请日：2015-10-28

Applicant: Macau University of Science and Technology

Inventor： Kam Wai WONG ,  Yuen Kwan LAW ,  Liang LIU

IPC: A61K31/4745

CPC classification number: A61K31/4745

Abstract: The present invention discloses a method of treating cancer and/or multidrug-resistant cancer, comprising administering an effective amount of hernandezine or thalidezine. A pharmaceutical composition comprising hernandezine or thalidezine admixed with a pharmaceutical carrier for treating cancers and/or multidrug-resistant cancer is also disclosed.

Abstract translation: 本发明公开了一种治疗癌症和/或多药耐药性癌症的方法，其包括施用有效量的涕灭威或沙利度胺。 还公开了包含与用于治疗癌症和/或多药耐药性癌症的药物载体混合的栀子苷或沙利度胺的药物组合物。

公开(公告)号：US20170019933A1

公开(公告)日：2017-01-19

申请号：US14828159

申请日：2015-08-17

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Fangxin Xu ,  Yu Zeng ,  Jie Yang

IPC: H04W74/08 ,  H04W72/14

CPC classification number: H04W74/0866 ,  H04W74/008 ,  H04W74/02 ,  H04W74/08 ,  H04W74/0816

Abstract: A MAC protocol, useful for wireless local area networks (WLANs), is provided for improving throughput efficiency. The protocol includes three concurrent processes, and the channel is divided into a contention subchannel and a transmission subchannel. In the contention process, all nodes use the standard RTS/CTS mechanism operated on the contention channel to contend for a right of transmission. When one node gains the right, all the nodes store the contention result into their respective contention queue (CQ) buffers. In the transmission process, the nodes sequentially transmit their data over the transmission channel according to the order of the nodes stored in the CQ buffers. When one node finishes data transmission, the CQ buffers are updated. The contention process and the transmission process are connected by the queuing process, where each node dynamically updates its own CQ buffer according to the contention result and each instance of data transmission.

Abstract translation: 提供了一种用于无线局域网（WLAN）的MAC协议，用于提高吞吐量效率。 该协议包括三个并发进程，并且该信道被划分为竞争子信道和传输子信道。 在竞争过程中，所有节点都使用在争用通道上运行的标准RTS / CTS机制来争取传输权。 当一个节点获得权限时，所有节点将争用结果存储到它们各自的争用队列（CQ）缓冲器中。 在传输过程中，节点根据存储在CQ缓冲器中的节点的顺序，依次通过传输信道发送它们的数据。 当一个节点完成数据传输时，更新CQ缓冲区。 竞争过程和传输过程通过排队过程连接，其中每个节点根据竞争结果和每个数据传输实例动态更新自己的CQ缓冲区。