公开(公告)号：US20170281702A1

公开(公告)日：2017-10-05

申请号：US15089687

申请日：2016-04-04

Applicant: Macau University of Science and Technology

Inventor： Jing-Rong Wang ,  Zhi-Hong Jiang ,  Qi-Tong Feng ,  Guo-Yuan Zhu ,  Wei-Na Gao ,  Zifeng Yang ,  Nanshan Zhong

IPC: A61K36/19 ,  A61K31/7056 ,  A61K31/192 ,  A61K31/404 ,  A61K31/047 ,  A61K31/191 ,  A61K31/538 ,  A61K31/517

CPC classification number: A61K36/19 ,  A61K31/404 ,  A61K31/538 ,  A61K31/567 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.

公开(公告)号：US09782401B1

公开(公告)日：2017-10-10

申请号：US15142373

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K36/24 ,  A61K31/4745

CPC classification number: A61K31/4745 ,  A61K36/24

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

公开(公告)号：US20170312266A1

公开(公告)日：2017-11-02

申请号：US15142373

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/24

CPC classification number: A61K31/4745 ,  A61K36/24

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

公开(公告)号：US10537601B2

公开(公告)日：2020-01-21

申请号：US15089687

申请日：2016-04-04

Applicant: Macau University of Science and Technology

Inventor： Jing-Rong Wang ,  Zhi-Hong Jiang ,  Qi-Tong Feng ,  Guo-Yuan Zhu ,  Wei-Na Gao ,  Zifeng Yang ,  Nanshan Zhong

IPC: A61K36/19 ,  A61K31/47 ,  A61K31/191 ,  A61K31/192 ,  A61K31/404 ,  A61K31/517 ,  A61K31/538 ,  A61K31/7056 ,  A61K31/567

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.

公开(公告)号：US10155721B2

公开(公告)日：2018-12-18

申请号：US15495949

申请日：2017-04-24

Applicant: Macau University of Science and Technology

Inventor： Guo-Yuan Zhu ,  Zhi-Hong Jiang ,  Ji Yang ,  Xiao-Jun Yao ,  Xin Liu ,  Jing Fu ,  Li-Ping Bai ,  Liang Liu

IPC: C07C237/26 ,  C07C231/24

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.

公开(公告)号：US10278966B2

公开(公告)日：2019-05-07

申请号：US15142407

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/27

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

公开(公告)号：US20170312267A1

公开(公告)日：2017-11-02

申请号：US15142407

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/24

CPC classification number: A61K31/4745 ,  A61K36/27

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.