公开(公告)号：US20100179766A1

公开(公告)日：2010-07-15

申请号：US12602481

申请日：2008-06-02

Applicant: Sangtae Kim ,  Nitin Gupta ,  Pavel A. Pevzner

Inventor： Sangtae Kim ,  Nitin Gupta ,  Pavel A. Pevzner

IPC: G01N33/68 ,  G06F19/00 ,  H01J49/26

CPC classification number: G06F19/22 ,  G01N33/6848 ,  G06F19/12 ,  G06F19/18 ,  H01J49/0036

Abstract: A method for identifying peptides using tandem mass spectrometry takes the spectrum for a peptide to be analyzed and uses a scoring function to score a match between the spectrum and each candidate peptide in a peptide database. The scoring function has a value corresponding to a number of fragment peaks in the spectrum that match fragment peaks in a spectrum of the candidate peptide. Using the match scores, a generating function of the spectrum is computed to determine the number of peptide reconstructions at each value of the scoring function. The generating function is then used to determine the number of candidate peptides for each match score and the probability of a peptide having a given match score to the spectrum. A spectral probability can be determined by calculating the total probability of all peptides with scores equal to or larger than the given match score.

Abstract translation: 使用串联质谱法鉴定肽的方法取得待分析肽的光谱，并使用评分函数对肽数据库中的光谱和每个候选肽之间的匹配进行评分。 评分函数具有对应于与候选肽的谱中的片段峰匹配的谱中的片段峰数的值。 使用匹配分数，计算光谱的生成函数，以确定在评分函数的每个值处的肽重构的数量。 然后使用生成函数来确定每个匹配得分的候选肽的数目和具有给定匹配得分的肽对于该光谱的概率。 可以通过计算具有等于或大于给定匹配分数的分数的所有肽的总概率来确定光谱概率。

公开(公告)号：US07688743B2

公开(公告)日：2010-03-30

申请号：US11494692

申请日：2006-07-27

Applicant: Alain J. Cohen ,  Pradeep K. Singh ,  Vinod Jeyachandran ,  Nitin Gupta

Inventor： Alain J. Cohen ,  Pradeep K. Singh ,  Vinod Jeyachandran ,  Nitin Gupta

IPC: H04L12/26 ,  H04L12/28

CPC classification number: H04L45/28 ,  H04L45/02 ,  H04L45/54

Abstract: A routing validation method and system identifies routers that are likely to be the cause of differences in forwarding tables associated with two versions of a network. Each destination sub-network prefix is processed to identify all the routers that exhibit differences in their forwarding table for this prefix. Each router exhibiting a difference is assessed to determine whether the difference may have been propagated to this router from another router. If the difference could not have been propagated from another router, this router is identified as a potential source of the observed difference. By eliminating routers that could have received the effects of the differences from another router, the task of identifying the root cause of the observed differences is substantially reduced in complexity.

Abstract translation: 路由验证方法和系统识别可能是与两个网络版本相关联的转发表中的差异的原因的路由器。 处理每个目标子网络前缀以标识在其前缀的转发表中表现出差异的所有路由器。 评估每个出现差异的路由器，以确定差异是否可能已经从另一个路由器传播到该路由器。 如果差异不能从另一个路由器传播，则该路由器被识别为观察到的差异的潜在来源。 通过消除可能已经接收到来自另一个路由器的差异的影响的路由器，识别所观察到的差异的根本原因的任务在复杂性上显着降低。

公开(公告)号：US20100049970A1

公开(公告)日：2010-02-25

申请号：US12502983

申请日：2009-07-14

Applicant: Charles Fraleigh ,  Nitin Gupta ,  Case Larsen ,  Shashidhar Merugu ,  Eric Ogren ,  Paras Shah ,  Oleg Smolsky

Inventor： Charles Fraleigh ,  Nitin Gupta ,  Case Larsen ,  Shashidhar Merugu ,  Eric Ogren ,  Paras Shah ,  Oleg Smolsky

IPC: H04L29/06

CPC classification number: H04L63/0823 ,  H04L63/166

Abstract: A local network traffic processor and an application are resident on a common computer system. The application is configured to trust a server certificate issued by a local network traffic processor, the local network traffic processor operatively being paired with a remote network traffic processor. A proxy server certificate, generated using identification information of a server associated with the remote network traffic processor and signed by the local certification authority, is used to establish a secure session between a local network traffic processor and the application.

Abstract translation: 本地网络流量处理器和应用程序驻留在通用计算机系统上。 该应用被配置为信任由本地网络流量处理器颁发的服务器证书，本地网络流量处理器可操作地与远程网络流量处理器配对。 使用由与远程网络流量处理器相关联并由本地认证机构签名的服务器的标识信息生成的代理服务器证书来建立本地网络流量处理器和应用之间的安全会话。

公开(公告)号：US09597711B2

公开(公告)日：2017-03-21

申请号：US14111568

申请日：2012-04-20

Applicant: Pranamesh Das ,  Nitin Gupta ,  Khadak Singh ,  Abdul Rehman

Inventor： Pranamesh Das ,  Nitin Gupta ,  Khadak Singh ,  Abdul Rehman

IPC: B03B9/06 ,  B07B1/46 ,  B07B1/28 ,  H05K13/04

CPC classification number: B07B1/46 ,  B07B1/28 ,  H05K13/0486

Abstract: The proposed invention relates to an apparatus and a method of separating all the parts including but not limited to electronic components, mechanical components, and electromechanical components, modules etc either individually or in sections and modular parts from the main input PCB. The proposed invention is an apparatus and method for component removal during recycling of an electronic device comprising in combination an isothermal system; heating to achieve desired range of temperature within the said isothermal system; at least one system for mechanical handling of the object being recycled; at least one system for selective separation of components being removed.

公开(公告)号：US09367619B2

公开(公告)日：2016-06-14

申请号：US13194084

申请日：2011-07-29

Applicant: Atul Katiyar ,  Purushottam Amradkar ,  Nitin Gupta

Inventor： Atul Katiyar ,  Purushottam Amradkar ,  Nitin Gupta

IPC: G06F17/30

CPC classification number: G06F17/30864 ,  G06F17/30846

Abstract: An analytic system may have a number of processing stages. One or more data sources may provide data to a first processing stage. The first processing stage may specify one or more data contracts having a schema describing a layout and types of data provided by the one or more data sources. Each of the processing stages may specify a respective data contract having a schema such that the processing stages may understand a layout and types of data provided as input to the processing stages. The data contracts me further specify a valid range of values for various items of data described by schemas. Data not conforming to a data contract may be automatically filtered out such that a corresponding processing stage may not be provided with the non-conforming data.

Abstract translation: 分析系统可能具有多个处理阶段。 一个或多个数据源可以向第一处理阶段提供数据。 第一处理阶段可以指定具有描述由一个或多个数据源提供的布局和数据类型的模式的一个或多个数据契约。 每个处理阶段可以指定具有模式的相应数据契约，使得处理阶段可以理解作为处理阶段的输入提供的数据的布局和类型。 数据约定我进一步指定了由模式描述的各种数据项的有效范围值。 可能会自动过滤掉不符合数据合约的数据，从而可能不会对不合格的数据提供相应的处理阶段。

公开(公告)号：US09014012B2

公开(公告)日：2015-04-21

申请号：US12900357

申请日：2010-10-07

Applicant: Vinod Jeyachandran ,  Pradeep Natarajan ,  James Mark Shaw ,  Raghavendra Uppalli ,  Pradeep Singh ,  Nitin Gupta ,  Jerrold Stiffler

Inventor： Vinod Jeyachandran ,  Pradeep Natarajan ,  James Mark Shaw ,  Raghavendra Uppalli ,  Pradeep Singh ,  Nitin Gupta ,  Jerrold Stiffler

IPC: H04L1/00 ,  H04L12/24

CPC classification number: H04L41/12 ,  H04L41/0213

Abstract: A network analysis system invokes an application specific, or source-destination specific, path discovery process. The application specific path discovery process determines the path(s) used by the application, collects performance data from the nodes along the path, and communicates this performance data to the network analysis system for subsequent performance analysis. The system may also maintain a database of prior network configurations to facilitate the identification of nodes that are off the path that may affect the current performance of the application. The system may also be specifically controlled so as to identify the path between any pair of specified nodes, and to optionally collect performance data associated with the path.

Abstract translation: 网络分析系统调用特定于应用程序或源特定路径的路径发现过程。 应用程序特定路径发现过程确定应用程序使用的路径，从沿着路径的节点收集性能数据，并将该性能数据传达到网络分析系统以进行后续性能分析。 系统还可以维护先前网络配置的数据库，以便于识别可能影响应用的当前性能的路径之外的节点。 还可以特别地控制系统，以便识别任何一对指定节点之间的路径，并且可选地收集与该路径相关联的性能数据。

公开(公告)号：US20140304302A1

公开(公告)日：2014-10-09

申请号：US13816382

申请日：2011-08-15

Applicant: Johannes Gehrke ,  Christoph Koch ,  Lucja Kot ,  Nitin Gupta

Inventor： Johannes Gehrke ,  Christoph Koch ,  Lucja Kot ,  Nitin Gupta

IPC: G06F17/30

CPC classification number: G06F16/24554 ,  G06F16/2425

Abstract: A computer system and computer implemented method that obtains coordinated results from at least two queries by utilizing context data of each query. Specifically, the computer system and computer implemented method facilitates enhanced querying functionality by matching entangled queries to achieve coordinated results.

Abstract translation: 一种计算机系统和计算机实现的方法，其通过利用每个查询的上下文数据从至少两个查询获得协调的结果。 具体来说，计算机系统和计算机实现的方法通过匹配纠缠的查询来实现协调的结果来促进增强的查询功能。

公开(公告)号：US08745320B2

公开(公告)日：2014-06-03

申请号：US13464714

申请日：2012-05-04

Applicant: Nitin Gupta ,  Kiron Vijayasankar ,  Joshua Berry

Inventor： Nitin Gupta ,  Kiron Vijayasankar ,  Joshua Berry

IPC: G06F12/02 ,  G06F3/06

CPC classification number: G06F3/0656 ,  G06F3/0619 ,  G06F3/0685 ,  G06F11/1441 ,  G06F11/1471 ,  G06F2201/82

Abstract: Relatively small capacity solid-state storage devices (SSD) are combined with larger capacity magnetic disk storage devices for storing storage block write data to ensure data consistency. Write operations are stored in a sequential write buffer in an SSD to guarantee the storage of write data and then copied from the sequential write buffer to the destination address in a magnetic disk storage device. The sequential write buffer store write data in locations corresponding to the order of receipt of write operations. Write data from the sequential write buffer is transferred to the magnetic disk storage device in the same order and a checkpoint index is frequently updated to indicate the completion of some transfers. During system initialization, the most recent value of the checkpoint index is retrieved and used as a starting location for transferring write data from the sequential write buffer to the magnetic disk storage device.

Abstract translation: 相对较小容量的固态存储设备（SSD）与更大容量的磁盘存储设备相结合，用于存储存储块写数据，以确保数据一致性。 写入操作存储在SSD中的顺序写入缓冲器中，以保证写入数据的存储，然后从顺序写入缓冲器复制到磁盘存储设备中的目标地址。 顺序写入缓冲器将写入数据写入对应于写入操作的接收顺序的位置。 从顺序写入缓冲器写入的数据以相同的顺序被传送到磁盘存储设备，并且检查点索引被频繁更新以指示某些传输的完成。 在系统初始化期间，检索点索引的最新值被检索并用作将写入数据从顺序写入缓冲器传送到磁盘存储设备的起始位置。

公开(公告)号：US08524893B2

公开(公告)日：2013-09-03

申请号：US13016235

申请日：2011-01-28

Applicant: Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

Inventor： Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

IPC: C07D498/00

CPC classification number: C07D498/18 ,  C07D319/06

Abstract: Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

Abstract translation: 新型中间体，其制备方法及其在制备治疗有效的抗肿瘤药物中的用途，特别是式（I）的替西罗莫司。

公开(公告)号：US20130184455A1

公开(公告)日：2013-07-18

申请号：US13809081

申请日：2011-07-11

Applicant: Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

Inventor： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC: C08B31/10

CPC classification number: A61K47/36 ,  A61K47/61 ,  C08B31/10

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract translation: 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述 仲羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。