公开(公告)号：US20110184167A1

公开(公告)日：2011-07-28

申请号：US13016235

申请日：2011-01-28

申请人： Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

发明人： Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

IPC分类号： C07D498/12 ,  C07D407/12

CPC分类号： C07D498/18 ,  C07D319/06

摘要： Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

摘要翻译： 新型中间体，其制备方法及其在制备治疗有效的抗肿瘤药物中的用途，特别是式（I）的替西罗莫司。

公开(公告)号：US08524893B2

公开(公告)日：2013-09-03

申请号：US13016235

申请日：2011-01-28

申请人： Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

发明人： Nitin Gupta ,  Vishal Handa ,  Abir Kumar Pal ,  Hemant Kumar Singh ,  Saswata Lahiri ,  Sushil Kumar Dubey

IPC分类号： C07D498/00

CPC分类号： C07D498/18 ,  C07D319/06

摘要： Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

摘要翻译： 新型中间体，其制备方法及其在制备治疗有效的抗肿瘤药物中的用途，特别是式（I）的替西罗莫司。

公开(公告)号：US20140088298A9

公开(公告)日：2014-03-27

申请号：US13809194

申请日：2011-07-11

申请人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

发明人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC分类号： A61K47/36

CPC分类号： A61K47/4823 ,  A61K47/36 ,  A61K47/61 ,  C08B31/10

摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

摘要翻译： 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟基 - 烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，细胞毒性剂包含至少一个仲羟基，其中羟烷基淀粉连接 通过所述仲羟基与细胞毒性剂接触。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US20130211060A1

公开(公告)日：2013-08-15

申请号：US13809194

申请日：2011-07-11

申请人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacker ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

发明人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacker ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC分类号： A61K47/36

CPC分类号： A61K47/36 ,  A61K47/61 ,  C08B31/10

摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

摘要翻译： 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟基 - 烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，细胞毒性剂包含至少一个仲羟基，其中羟烷基淀粉连接 通过所述仲羟基与细胞毒性剂接触。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US20140073779A9

公开(公告)日：2014-03-13

申请号：US13809081

申请日：2011-07-11

申请人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

发明人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC分类号： C08B31/10

CPC分类号： A61K47/4823 ,  A61K47/36 ,  A61K47/61 ,  C08B31/10

摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

摘要翻译： 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述 仲羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US20130184455A1

公开(公告)日：2013-07-18

申请号：US13809081

申请日：2011-07-11

申请人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

发明人： Helmut Knoller ,  Dominik Heckmann ,  Frank Hacket ,  Norbert Zander ,  Frank Nocken ,  Saswata Lahiri ,  Nitin Gupta ,  Sunil Sanghani ,  Azim Abul ,  Hemant Kumar Singh ,  Sandeep Grewal ,  Sandeep Kaur

IPC分类号： C08B31/10

CPC分类号： A61K47/36 ,  A61K47/61 ,  C08B31/10

摘要： The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

摘要翻译： 本发明涉及羟烷基淀粉缀合物及其制备方法，所述羟烷基淀粉缀合物包含羟烷基淀粉衍生物和细胞毒性剂，所述细胞毒性剂包含至少一个仲羟基，其中所述羟烷基淀粉通过所述 仲羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'（ - LM）n的结构，其中M是细胞毒性剂的残基，L是连接部分，HAS'是羟烷基淀粉衍生物的残基，和 n大于或等于1，并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量（MW）。

公开(公告)号：US08188143B2

公开(公告)日：2012-05-29

申请号：US11688359

申请日：2007-03-20

申请人： Janaswamy Madhusudana Rao ,  Bhimapaka China Raju ,  Pullela Venkata Srinivas ,  Katragadda Suresh Babu ,  Jhillu Singh Yadav ,  Kondapuram Vijaya Raghvan ,  Hemant Kumar Singh ,  Chandiswar Nath

发明人： Janaswamy Madhusudana Rao ,  Bhimapaka China Raju ,  Pullela Venkata Srinivas ,  Katragadda Suresh Babu ,  Jhillu Singh Yadav ,  Kondapuram Vijaya Raghvan ,  Hemant Kumar Singh ,  Chandiswar Nath

IPC分类号： A61K31/35

CPC分类号： A61K31/37

摘要： The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marmesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7-methoxy coumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions posses a high degree of acetylcholinesterase inhibitory (AChE) property.

摘要翻译： 本发明涉及包含天然存在的化合物的药物组合物，所述化合物选自（±）马尔西辛，哥伦比亚甜素，二羟基黄酮和7-烯丙氧基香豆素的取代香豆素衍生物，7-苄氧基香豆素，7-甲氧基香豆素，7-乙酰氧基香豆素，4-甲基 -7-羟基香豆素和4-甲基-7-乙酰氧基香豆素。 所述组合物具有高度的乙酰胆碱酯酶抑制（AChE）特性。

公开(公告)号：US06896901B2

公开(公告)日：2005-05-24

申请号：US09742424

申请日：2000-12-22

申请人： Ram Pratap ,  Raghwendra Pal ,  Satyawan Singh ,  Girja Shankar ,  Chandeshwar Nath ,  Hemant Kumar Singh ,  Depak Raina ,  Arwind Kumar Srivastava ,  Anil Kumar Rastogi ,  Puvvada Sri Ramachandra Murthy ,  Sudhir Srivastava ,  Onkar Prasad Asthana ,  Narenda Singh ,  Nitya Nand

发明人： Ram Pratap ,  Raghwendra Pal ,  Satyawan Singh ,  Girja Shankar ,  Chandeshwar Nath ,  Hemant Kumar Singh ,  Depak Raina ,  Arwind Kumar Srivastava ,  Anil Kumar Rastogi ,  Puvvada Sri Ramachandra Murthy ,  Sudhir Srivastava ,  Onkar Prasad Asthana ,  Narenda Singh ,  Nitya Nand

IPC分类号： A61K9/06 ,  A61K9/14 ,  A61K9/19 ,  A61K9/20 ,  A61K9/48 ,  A61K31/575 ,  A61K31/7024 ,  A61K36/00 ,  A61K36/18 ,  A61K36/328 ,  A61K47/04 ,  A61K47/12 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P3/00 ,  A61P3/10 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P37/08 ,  A61K35/78

CPC分类号： A61K36/328 ,  A61K31/575

摘要： The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant Comiphora wighitii, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

摘要翻译： 本发明提供了Gogulipid（一种用于控制或预防认知功能障碍，高血糖症和一些皮肤感染病症）的树脂的乙酸乙酯提取物的新用途，以及通过搅拌摇瓶中的树脂制备Gugilipid的方法 组装或超声处理组件，并制备固体或乳膏剂型。

公开(公告)号：US20120277297A1

公开(公告)日：2012-11-01

申请号：US13460472

申请日：2012-04-30

申请人： Janaswamy Madhusudana Rao ,  Bhimapaka China Raju ,  Pullela Venkata Srinivas ,  Katragadda Suresh Babu ,  Jhillu Singh Yadav ,  Kondapuram Vijaya Raghvan ,  Hemant Kumar Singh ,  Chandiswar Nath

发明人： Janaswamy Madhusudana Rao ,  Bhimapaka China Raju ,  Pullela Venkata Srinivas ,  Katragadda Suresh Babu ,  Jhillu Singh Yadav ,  Kondapuram Vijaya Raghvan ,  Hemant Kumar Singh ,  Chandiswar Nath

IPC分类号： A61K31/37 ,  C07D493/04 ,  A61P25/28 ,  C07D311/20

CPC分类号： A61K31/37

摘要： The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marrnesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7 -methoxycoumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions possess a high degree of acetylcholinesterase inhibitory (AChE) property.

摘要翻译： 本发明涉及药物组合物，其包含天然存在的化合物，其选自（±）Marrnesin，Columbianetin，二氢黄酮和7-烯丙氧基香豆素的取代香豆素衍生物，7-苄氧基香豆素，7-甲氧基香豆素，7-乙酰氧基香豆素，4-甲基 - 7-羟基香豆素和4-甲基-7-乙酰氧基香豆素。 所述组合物具有高度的乙酰胆碱酯酶抑制（AChE）特性。