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公开(公告)号:US10829553B2
公开(公告)日:2020-11-10
申请号:US15581079
申请日:2017-04-28
发明人: Stefano V. Gulla , Christine Huard , Janet Elizabeth Buhlmann , Juan Carlos Almagro , Sreekumar R. Kodangattil , Steven A. Greenberg , Edward Roland Lavallie , Eric M. Bennett , Lidia Mosyak , James Perry Hall , Anthony John Coyle
摘要: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.
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公开(公告)号:US10829521B2
公开(公告)日:2020-11-10
申请号:US16713782
申请日:2019-12-13
申请人: PFIZER INC.
发明人: Annaliesa Sybil Anderson , Susan Kay Hoiseth , Kathrin Ute Jansen , Justin Keith Moran , Mark Edward Ruppen
IPC分类号: A61K39/095 , C07K14/22 , A61K39/00
摘要: In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B polypeptide and methods of use thereof. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup, and methods of use thereof.
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公开(公告)号:US10815240B2
公开(公告)日:2020-10-27
申请号:US16502703
申请日:2019-07-03
申请人: Pfizer Inc.
发明人: Kapildev Kashmirilal Arora , Jacob Cole DeForest , Andrew Kevern Hills , Brian Patrick Jones , Kris Nicole Jones , Chad Arthur Lewis , Anil Mahadeo Rane
IPC分类号: C07D487/04 , C07D249/08
摘要: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.
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公开(公告)号:US20200325228A1
公开(公告)日:2020-10-15
申请号:US16742657
申请日:2020-01-14
IPC分类号: C07K16/28 , A61K39/395 , A61K31/4439 , A61K45/06 , C07K16/30
摘要: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a VEGFR inhibitor, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L 1.
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公开(公告)号:US10800783B2
公开(公告)日:2020-10-13
申请号:US16251032
申请日:2019-01-17
申请人: Pfizer Inc.
发明人: Douglas Carl Behenna , Ping Chen , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Mehran Jalaie , Asako Nagata , Sajiv Krishnan Nair , Sacha Ninkovic , Martha Alicia Ornelas , Cynthia Louise Palmer , Eugene Yuanjin Rui
IPC分类号: A61K31/519 , A61K31/4375 , A61K31/4545 , C07D487/04 , C07D401/12 , C07D471/04 , C07D401/14
摘要: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号:US20200283536A1
公开(公告)日:2020-09-10
申请号:US16758124
申请日:2018-10-16
申请人: Pfizer Inc.
发明人: Manoj Baburao CHARATI , Yoon-Chi HAN , Madan KATRAGADDA , Nicole Melissa PICHÉ-NICHOLAS , Lawrence Nathan TUMEY
摘要: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).
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公开(公告)号:US20200268740A1
公开(公告)日:2020-08-27
申请号:US16762388
申请日:2018-11-09
申请人: Pfizer Inc.
IPC分类号: A61K31/4725 , A61K33/243 , A61K31/357 , A61K45/06 , A61P35/00 , A61K39/395 , A61K31/5355 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/4433 , A61K31/4412
摘要: This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.
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公开(公告)号:US20200255406A1
公开(公告)日:2020-08-13
申请号:US16861646
申请日:2020-04-29
申请人: Pfizer Inc.
发明人: Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC分类号: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
摘要: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号:US20200247784A1
公开(公告)日:2020-08-06
申请号:US16774786
申请日:2020-01-28
申请人: Pfizer Inc.
发明人: Douglas Carl Behenna , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Asako Nagata , Sacha Ninkovic , Scott Channing Sutton
IPC分类号: C07D403/12 , C07D413/12 , A61P35/00
摘要: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.
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公开(公告)号:US20200246448A1
公开(公告)日:2020-08-06
申请号:US16774309
申请日:2020-01-28
申请人: PFIZER INC.
发明人: Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC分类号: A61K39/095 , A61K47/64 , A61K45/06 , A61K39/09
摘要: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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