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公开(公告)号：US20200157212A1
公开(公告)日：2020-05-21
申请号：US16614701
申请日：2018-06-08
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US10906955B2
公开(公告)日：2021-02-02
申请号：US15995286
申请日：2018-06-01
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , C07H21/04 , A61P13/12 , A61K38/17 , A61K38/00
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US20180346542A1
公开(公告)日：2018-12-06
申请号：US15995286
申请日：2018-06-01
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , A61P13/12
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US11970524B2
公开(公告)日：2024-04-30
申请号：US17125903
申请日：2020-12-17
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00
CPC分类号： C07K14/70503 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00 , C07K2319/30 , C07K2319/31 , C07K2319/70
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US11365253B2
公开(公告)日：2022-06-21
申请号：US16614701
申请日：2018-06-08
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/28 , A61P13/12 , C12N15/85
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US20210214414A1
公开(公告)日：2021-07-15
申请号：US17125903
申请日：2020-12-17
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , C12N15/11 , C12N15/52 , C12N15/09 , C07K19/00 , C12N15/63 , C07H21/04 , A61K38/17 , A61P13/12
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US10358677B2
公开(公告)日：2019-07-23
申请号：US15399848
申请日：2017-01-06
发明人： Weining Lu , Xueping Fan , David J. Salant
IPC分类号： A61K38/17 , A61P13/12 , A61P13/02 , C12Q1/6883 , G01N33/68 , A61K45/06 , C07K14/705 , A61K31/7088 , A61K31/713 , A61K39/395 , C07K14/47 , C07K16/18 , C12N15/113 , C12N15/115 , G16H50/30 , G06F19/20 , G06F19/00
摘要： Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
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8.发明申请公开(公告)号：US20150037325A1
公开(公告)日：2015-02-05
申请号：US14369094
申请日：2013-01-04
发明人： Weining Lu , Xueping Fan , David J. Salant
IPC分类号： A61K39/395 , C12N15/113 , C12N15/115 , A61K38/17 , A61K45/06 , A61K31/713 , A61K31/7088 , C07K16/18 , C07K14/47
CPC分类号： C12Q1/6883 , A61K31/7088 , A61K31/713 , A61K38/1709 , A61K38/177 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61P13/02 , A61P13/12 , C07K14/47 , C07K14/70503 , C07K16/18 , C07K2317/24 , C07K2319/70 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2333/70503 , G01N2800/347 , G06F19/00 , G06F19/20 , G06F19/3456 , G16H50/30 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要： Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
摘要翻译： 本文提供了用于治疗慢性肾脏疾病和蛋白尿的方法以及用于诊断慢性肾脏疾病的方法，并且基于SLIT-ROBO信号通路在调节中的意想不到的角色来监测治疗对慢性肾脏疾病和蛋白尿进展的影响 的足细胞F-肌动蛋白细胞骨架和脚过程结构在肾脏。
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9.发明授权ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2 有权包含ROBO2的SLIT2结合细胞外结构域的ROBO 2抑制组合物公开(公告)号：US09572879B2
公开(公告)日：2017-02-21
申请号：US14369094
申请日：2013-01-04
发明人： Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , C12Q1/68 , G01N33/68 , A61K45/06 , A61K31/7088 , A61K31/713 , C07K14/47 , C07K16/18 , C12N15/113 , C12N15/115 , A61P13/12
CPC分类号： C12Q1/6883 , A61K31/7088 , A61K31/713 , A61K38/1709 , A61K38/177 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61P13/02 , A61P13/12 , C07K14/47 , C07K14/70503 , C07K16/18 , C07K2317/24 , C07K2319/70 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2333/70503 , G01N2800/347 , G06F19/00 , G06F19/20 , G06F19/3456 , G16H50/30 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要： Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
摘要翻译： 本文提供了用于治疗慢性肾脏疾病和蛋白尿的方法以及用于诊断慢性肾脏疾病的方法，并且基于SLIT-ROBO信号通路在调节中的意想不到的角色来监测治疗对慢性肾脏疾病和蛋白尿进展的影响 的足细胞F-肌动蛋白细胞骨架和脚过程结构在肾脏。
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