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公开(公告)号：US11970524B2
公开(公告)日：2024-04-30
申请号：US17125903
申请日：2020-12-17
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00
CPC分类号： C07K14/70503 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00 , C07K2319/30 , C07K2319/31 , C07K2319/70
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US11365253B2
公开(公告)日：2022-06-21
申请号：US16614701
申请日：2018-06-08
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/28 , A61P13/12 , C12N15/85
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US20210214414A1
公开(公告)日：2021-07-15
申请号：US17125903
申请日：2020-12-17
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , C12N15/11 , C12N15/52 , C12N15/09 , C07K19/00 , C12N15/63 , C07H21/04 , A61K38/17 , A61P13/12
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US20200157212A1
公开(公告)日：2020-05-21
申请号：US16614701
申请日：2018-06-08
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
摘要： The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US10906955B2
公开(公告)日：2021-02-02
申请号：US15995286
申请日：2018-06-01
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , C07H21/04 , A61P13/12 , A61K38/17 , A61K38/00
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US20180346542A1
公开(公告)日：2018-12-06
申请号：US15995286
申请日：2018-06-01
发明人： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC分类号： C07K14/705 , A61P13/12
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30
摘要： The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US20180179285A1
公开(公告)日：2018-06-28
申请号：US15309879
申请日：2015-05-13
申请人： Pfizer Inc.
发明人： Eric M. Bennett , Nathan Higginson-Scott , Lioudmila Tchistiakova , Kimberly A. Marquette , Janet E. Paulsen , Ruth E. Gimeno
CPC分类号： C07K16/2863 , A61P27/16 , C07K16/00 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/522 , C07K2317/55 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
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公开(公告)号：US10392438B2
公开(公告)日：2019-08-27
申请号：US15309879
申请日：2015-05-13
申请人： Pfizer Inc.
发明人： Eric M. Bennett , Nathan Higginson-Scott , Lioudmila Tchistiakova , Kimberly A. Marquette , Janet E. Paulsen , Ruth E. Gimeno
摘要： The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
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