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    SYSTEMS AND METHODS OF SENSING AND ANALYZING ANTIBODY BLOCKING INTERACTIONS
    71.
    发明申请
    SYSTEMS AND METHODS OF SENSING AND ANALYZING ANTIBODY BLOCKING INTERACTIONS 审中-公开
    感测和分析抗体阻塞相互作用的系统和方法

    公开(公告)号：US20150269312A1

    公开(公告)日：2015-09-24

    申请号：US14558109

    申请日：2014-12-02

    Applicant: Wasatch Microfluidics, Inc. ,  Rinat Neuroscience Corp.

    Inventor： Adam Miles ,  Joshua W. Eckman ,  Yasmina Abdiche

    IPC: G06F19/18 ,  G01N21/552 ,  G01N33/68

    CPC classification number: G16B20/00 ,  G01N21/553 ,  G01N33/577 ,  G01N33/6854 ,  G16B45/00

    Abstract: A system and method for sensing and analyzing antibody blocking interactions is described. A biosensor can be used to identify interactions between antibodies to generate interaction profiles for the antibodies. A processor can be used to assign the antibodies to one or more bins, with the antibodies sharing a common interaction profile assigned to a common bin, and each antibody only being assigned to one bin. The antibodies can be represented by displaying nodes grouped together for antibodies in a common bin. Connections between the nodes can be displayed, representing interactions between the antibodies.

    Abstract translation: 描述了用于感测和分析抗体阻断相互作用的系统和方法。 可以使用生物传感器来鉴定抗体之间的相互作用以产生抗体的相互作用谱。 处理器可用于将抗体分配给一个或多个箱，抗体共享分配给公共仓的共同相互作用轮廓，并且每个抗体仅被分配到一个仓。 抗体可以通过将分组在一起的节点显示在公共箱中来表示抗体。 可以显示节点之间的连接，表示抗体之间的相互作用。

    ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
    72.
    发明申请
    ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING 审中-公开
    具有pH依赖性抗原结合的抗体

    公开(公告)号：US20150266974A1

    公开(公告)日：2015-09-24

    申请号：US14677983

    申请日：2015-04-03

    Applicant: RINAT NEUROSCIENCE CORP. ,  PFIZER INC.

    Inventor： Jaume PONS ,  Jeffrey Raymond CHABOT ,  Javier Fernando CHAPARRO RIGGERS ,  Bruce Charles GOMES ,  Hong LIANG ,  Kapil MAYAWALA ,  Jerome Thomas METTETAL, II ,  Arvind RAJPAL ,  David Louis SHELTON

    IPC: C07K16/42 ,  C07K16/40 ,  C07K16/28

    CPC classification number: C07K16/4291 ,  C07K16/28 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/21

    Abstract: The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the KD or koff ratio at pH 5.5/pH 7.4 or at pH 6.0/pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent KDs at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present at high levels (e.g., IgE, DKK1, C5 and SOST). In addition, such antibodies can increase antigen half life when the antigen is a receptor and the receptor has increased clearance when bound to antibody (e.g, GMCSF receptor).

    Abstract translation: 本发明涉及与其抗原具有pH依赖性结合的抗体，使得在生理pH（即pH 7.4）下抗原结合的亲和力大于内体pH（即pH6.0或5.5）时的亲和力。 换句话说，pH5.5 / pH7.4或pH6.0 / pH7.4下的KD或koff比大于或等于2,3,4,8,10,16,20,30,40或100 或者更多。 这种pH依赖性抗体优先从内体中的抗原解离。 与抗原为经过抗原介导的清除（例如，PCSK9）的抗原相比，与具有pH 7.4但具有pH依赖性结合的等效KD的抗体相比，可以增加抗体半衰期。 当与抗体（例如IL6）结合时，当抗原经历减少的清除时，具有pH依赖性结合的抗体可降低总抗原半衰期。 具有pH依赖性结合的抗体也可以延长不抗体结合的抗原的降低。 当拮抗通常以高水平存在的靶抗原（例如IgE，DKK1，C5和SOST）时，这可能是重要的。 此外，当抗原是受体时，这种抗体可以增加抗原半衰期，并且当与抗体（例如，GMCSF受体）结合时，该受体具有增加的清除能力。

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