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公开(公告)号：US08715673B2
公开(公告)日：2014-05-06
申请号：US13719214
申请日：2012-12-18
Applicant: Rinat Neuroscience Corp.
Inventor： Davide Luciano Foletti , Javier Fernando Chaparro Riggers , Jacob Eli Gunn Glanville , Lee Mary Beth Shaughnessy , David Louis Shelton , Pavel Strop , Wenwu Zhai
IPC: A61K39/40
CPC classification number: C07K16/1271 , A61K39/40 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.
Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明还涉及用于这些抗体用于治疗和/或预防葡萄球菌疾病（包括例如肺炎，菌血症，败血症，眼睛感染和脓肿）的治疗方法。
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公开(公告)号：US10323086B2
公开(公告)日：2019-06-18
申请号：US15287246
申请日：2016-10-06
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon Rosenthal , David Louis Shelton , Patricia Ann Walicke
IPC: C07K16/22 , A61K39/395 , A61K39/00
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US09340610B2
公开(公告)日：2016-05-17
申请号：US13946580
申请日：2013-07-19
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon Rosenthal , David Louis Shelton , Patricia Ann Walicke
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US11602525B2
公开(公告)日：2023-03-14
申请号：US15306481
申请日：2015-04-21
Applicant: RINAT NEUROSCIENCE CORP. , PFIZER INC.
Inventor： Pavel Strop , Katherine Anne Delaria , Magdalena Dorywalska , Davide Luciano Foletti , Russell George Dushin , David Louis Shelton , Arvind Rajpal
IPC: A61K31/427 , A61K47/68 , A61K47/65 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
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公开(公告)号：US11091544B2
公开(公告)日：2021-08-17
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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Patent Agency Ranking
公开(公告)号：US20190002559A1
公开(公告)日：2019-01-03
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US10100114B2
公开(公告)日：2018-10-16
申请号：US15160742
申请日：2016-05-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US09498530B2
公开(公告)日：2016-11-22
申请号：US13946532
申请日：2013-07-19
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon Rosenthal , David Louis Shelton , Patricia Ann Walicke
IPC: C07K16/22 , A61K39/395 , A61K39/00
CPC classification number: C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US09399074B2
公开(公告)日：2016-07-26
申请号：US14460871
申请日：2014-08-15
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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公开(公告)号：US08871908B2
公开(公告)日：2014-10-28
申请号：US13670730
申请日：2012-11-07
Applicant: Rinat Neuroscience Corp.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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