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公开(公告)号：US11091544B2
公开(公告)日：2021-08-17
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US10967068B2
公开(公告)日：2021-04-06
申请号：US15504801
申请日：2015-08-14
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Russell George Dushin , Pavel Strop , Magdalena Grazyna Dorywalska , Ludivine Moine
Abstract: The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, therapeutic methods using stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.
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公开(公告)号：US10941216B2
公开(公告)日：2021-03-09
申请号：US15593259
申请日：2017-05-11
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
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公开(公告)号：US10138303B2
公开(公告)日：2018-11-27
申请号：US15351275
申请日：2016-11-14
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Weihsien Ho , Jaume Pons , Arvind Rajpal , Pavel Strop
Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US09175093B2
公开(公告)日：2015-11-03
申请号：US13857063
申请日：2013-04-04
Applicant: RINAT NEUROSCIENCE CORP. , PFIZER INC.
Inventor： Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Xiayang Qiu , Pavel Strop , Yuli Wang
IPC: A61K39/395 , C07K16/40 , A61K45/06 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
Abstract translation: 本发明提供了与抗蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）结合的拮抗抗体，其抗原结合部分和适体。 还提供了针对肽的抗体，其中抗体结合PCSK9。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及使用这些抗体及其抗原结合部分来降低LDL-胆固醇水平和/或用于治疗和/或预防心血管疾病（包括治疗高胆固醇血症）的治疗方法。
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Patent Agency Ranking
公开(公告)号：US08715673B2
公开(公告)日：2014-05-06
申请号：US13719214
申请日：2012-12-18
Applicant: Rinat Neuroscience Corp.
Inventor： Davide Luciano Foletti , Javier Fernando Chaparro Riggers , Jacob Eli Gunn Glanville , Lee Mary Beth Shaughnessy , David Louis Shelton , Pavel Strop , Wenwu Zhai
IPC: A61K39/40
CPC classification number: C07K16/1271 , A61K39/40 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.
Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明还涉及用于这些抗体用于治疗和/或预防葡萄球菌疾病（包括例如肺炎，菌血症，败血症，眼睛感染和脓肿）的治疗方法。
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公开(公告)号：US11602525B2
公开(公告)日：2023-03-14
申请号：US15306481
申请日：2015-04-21
Applicant: RINAT NEUROSCIENCE CORP. , PFIZER INC.
Inventor： Pavel Strop , Katherine Anne Delaria , Magdalena Dorywalska , Davide Luciano Foletti , Russell George Dushin , David Louis Shelton , Arvind Rajpal
IPC: A61K31/427 , A61K47/68 , A61K47/65 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
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公开(公告)号：US10195289B2
公开(公告)日：2019-02-05
申请号：US14908492
申请日：2014-07-30
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Santiago Esteban Farias , Meritxell Galindo Casas , Pavel Strop
IPC: A61K47/68
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
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公开(公告)号：US20190321482A1
公开(公告)日：2019-10-24
申请号：US16231242
申请日：2018-12-21
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Santiago Esteban Farias , Meritxell Galindo Casas , Pavel Strop
IPC: A61K47/68
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
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公开(公告)号：US20190002559A1
公开(公告)日：2019-01-03
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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