DNA nanotechnology-based biomarker measurement platform

    公开(公告)号:US12195787B2

    公开(公告)日:2025-01-14

    申请号:US17360008

    申请日:2021-06-28

    Abstract: A biomarker signal amplifier amplifies chemical analyte binding and includes: a surface strand disposed on an analysis substrate and including an exchange region; a particle strand hybridized to the surface strand in an absence of a chemical analyte that preferentially hybridizes to the exchange region as compared with the particle strand, and the particle strand is dissociated from the surface strand when the surface strand is in a presence of the chemical analyte; and a reporter particle attached to the particle strand and disposed proximate to the analysis substrate when the particle strand is hybridized to the surface strand in absence of the chemical analyte and that changes the electrical potential of the analysis substrate depending on whether the particle strand is hybridized to the surface strand.

    System and method for measurment of magnetic nanoparticles

    公开(公告)号:US12188900B2

    公开(公告)日:2025-01-07

    申请号:US17669992

    申请日:2022-02-11

    Abstract: Embodiments of the present invention relate to a system and method for performing temperature-dependent measurements of a magnetic nanoparticle sample. The system includes high frequency coils and sample temperature tunable assembly to determine the specific relaxation process for magnetic nanoparticle sample using both time and frequency domain techniques. During the temperature-dependent measurements of a magnetic nanoparticle sample, system in accordance with embodiments of the present invention resolve the nanoparticle dynamics using a temperature-tunable dual mode, AC susceptibility and magnetic relaxometry, to cover a broad range of frequencies and time scales. Other operational modes of the invention can drive the nanoparticles with arbitrary waveforms (sinusoidal, sum of sinusoids, or repeated pulses) to elicit and measure tailored response behavior from the magnetic nanoparticle sample.

    CHIP TWEEZERS
    74.
    发明申请

    公开(公告)号:US20240420989A1

    公开(公告)日:2024-12-19

    申请号:US18745476

    申请日:2024-06-17

    Abstract: Chip tweezers for handling microchips include a body portion having a pair of arms coupled together at a proximal end and extending toward a distal end, wherein the arms are moveable towards and away from each other; and a head portion located at the distal end, the head portion including a pair of V-grooves disposed parallel to each other with open sides facing each other, each rigidly connected to a respective arm of the pair of arms.

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