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公开(公告)号：US10829770B2
公开(公告)日：2020-11-10
申请号：US16571616
申请日：2019-09-16
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Michael Puckette , Max V. Rasmussen
IPC: C12N15/63 , A61K38/21 , C07K14/705 , C12Q1/66 , C07K14/56 , C12N9/02 , C07K14/00 , C12N15/00 , A61K38/00
Abstract: Polynucleotides encoding fusion proteins contain a secretable luciferase fused to a modified polypeptide of interest are disclosed. The polypeptide of interest has been modified to remove a native N-terminal secretion sequence and has been replaced by the secretable luciferase. One example of a modified polypeptide of interest is interferon. The polynucleotides and fusion proteins have biotherapeutic, diagnostic, and quality control applications in biotechnological, medical, and veterinary fields. Methods for producing the secretable fusion protein are also disclosed.
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公开(公告)号：US10679310B2
公开(公告)日：2020-06-09
申请号：US16285636
申请日：2019-02-26
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： David Maher
Abstract: Mobile collection and vetting of user supplied information is described. The systems, techniques, devices, methods, and approaches described herein can be used to obtain, validate, and vet information, such as customs information, in a mobile environment. In embodiments, methods comprise receiving information input via a mobile device. The information is encapsulated by an intermediate to escort the information through a firewall to the database. In response to vetting the information to determine if it meets one or more criteria, the method involves creating a record associated with a unique identifier, information that bio-identifies a user, or an indication of a determination that results from the vetting. In this embodiment, the method includes generating an electronic receipt for communication to the mobile device, the electronic receipt including the unique identifier.
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公开(公告)号：US20200152045A1
公开(公告)日：2020-05-14
申请号：US16387280
申请日：2019-04-17
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Michael Luis Dougall , Jacob James Rath , Blaise Carlson Curtis , Liam Christian Otto , Frederick John McClimans , Matthew Tyler Williams , Thomas Carsten Rodzewicz , Ronald Adrezin , Michael Plumley
Abstract: A buoy corrosion detection system includes a buoy having a double hull section in which the outer hull is designed to corrode and fail prior to the rest of the hull. The double hull section is positioned at the waterline, which is the area most prone to corrosion. As the outer hull corrodes, water passes through the hull and is detected by a moisture detector. The moisture detector then relays a signal that water has entered through the hull, and a signaling circuit then sends a communication signal to the user indicating that the buoy has corrosion. The buoy corrosion detection system leads to an “as-needed” maintenance cycle for buoys.
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公开(公告)号：US20200148359A1
公开(公告)日：2020-05-14
申请号：US16368013
申请日：2019-03-28
Applicant: The Government of the United States of America as represented by the Secretary of Homeland Security
Inventor： Spencer Smith , Riely Brande , Nolan Richerson , Benjamin Crutchfield , Christian Breviario , Ronald Adrezin , Michael Plumley , Marion Lewandowski
Abstract: A rescue basket having the capacity to safely hold two full-sized individuals increases the efficiency and effectiveness of helicopter water rescue and recovery operations. The rescue basket includes an open end, which affords an additional option for loading passengers, along with a door mechanism that can at least partially close off the open end for passenger safety. The rescue basket includes a flotation system that maintains the basket at a desired flotation level when completely immersed in water, along with sufficient reserve buoyancy to safely maintain the passengers above water when loaded. Methods of performing a water rescue utilizing the present rescue basket on board of a helicopter are also provided.
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公开(公告)号：US20200112627A1
公开(公告)日：2020-04-09
申请号：US16691001
申请日：2019-11-21
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Richard Brockway
IPC: H04L29/06
Abstract: An interface device for provisioning Internet Protocol (IP) communications to be established for base station equipment that employ proprietary device specific protocols. A fixed station interface (FSI) translates between a V.24 High-Level-Data-Link Control (HDLC) protocols used for external data connections on base station equipment to a Voice-Over-Internet-Protocol (VOIP) open-standard protocol. Upon being deployed in First Responder communications networks (that use legacy base station equipment), the FSI provisions for the retention of existing installed base station equipment while providing a low cost solution to support VOIP communications interconnectivity and reliability, thereby enhancing the effectiveness and safety of the First Responder systems.
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Patent Agency Ranking
公开(公告)号：US10546358B2
公开(公告)日：2020-01-28
申请号：US16285520
申请日：2019-02-26
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： David Maher
Abstract: Mobile collection and vetting of user supplied information is described. The systems, techniques, devices, methods, and approaches described herein can be used to obtain, validate, and vet information, such as customs information, in a mobile environment. In embodiments, methods comprise receiving information input via a mobile device. The information is encapsulated by an intermediate to escort the information through a firewall to the database. In response to vetting the information to determine if it meets one or more criteria, the method involves creating a record associated with a unique identifier, information that bio-identifies a user, or an indication of a determination that results from the vetting. In this embodiment, the method includes generating an electronic receipt for communication to the mobile device, the electronic receipt including the unique identifier.
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公开(公告)号：US10513542B2
公开(公告)日：2019-12-24
申请号：US15957376
申请日：2018-04-19
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Michael Puckette , Max Rasmussen , John Neilan
IPC: C07K14/005 , G01N33/569 , A61K39/00
Abstract: This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the FMDV capsid polyprotein precursor into a plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.
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公开(公告)号：US20190195988A1
公开(公告)日：2019-06-27
申请号：US16230042
申请日：2018-12-21
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Ronald Krauss , Michael Brogden , Joseph McNamara
CPC classification number: G01S7/40 , G01S7/411 , G01S13/887
Abstract: Various embodiments of the present invention are directed towards a simulant and method relating to producing a simulant. For example, a simulant of a target threat includes at least one component ingredient characterized by a corresponding component loss factor that is essentially zero. The simulant is configured to exhibit a simulant dielectric constant corresponding to a simulant reflectivity substantially equivalent to a threat reflectivity. A method of producing a simulant of a target threat includes generating an ellipse-like curved solution space corresponding to a plurality of candidate threat reflectivities, identifying a threat dielectric constant, from among respective threat dielectric constants of the candidate threat reflectivities forming the curved solution space, and identifying at least one weight proportion of at least one corresponding simulant ingredient.
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公开(公告)号：US20190172330A1
公开(公告)日：2019-06-06
申请号：US16260801
申请日：2019-01-29
Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
Inventor： Mark A. Fry , Barry T. Smith
CPC classification number: G08B13/19697 , G06K9/00771 , G06T5/20 , G06T7/20 , G06T7/70 , H04N7/183 , H04N7/188
Abstract: A security system to detect motions and/or features associated with a traveler, the security system includes a camera configured to capture an image series of the traveler in an Eulerian or Lagrangian frame of reference, wherein the captured image series contains motions and features associated with the traveler; an alarm system configured to produce an alert signal; and an electronic control unit. The electronic control unit is configured to magnify the motions and features associated with the traveler to generate frame of reference perceptible motions and features, detect characteristic kinematic behaviors of the perceptible motions and features, measure characteristic kinematic quantities of the characteristic kinematic behaviors, determine the presence of features that deviate from a threshold value for the characteristic kinematic quantities, and activate the alarm system to produce the alert signal.
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公开(公告)号：US10214732B2
公开(公告)日：2019-02-26
申请号：US15047319
申请日：2016-02-18
Inventor： Segaran Pillai , Linda Weigel , Bernard Quigley , David R. Hodge
Abstract: Disclosed herein are the identification, cloning, and optimizing the lytic activity of one or more novel Bacillus lysin proteins, a method of selecting a lysin agent for use in molecular diagnostic testing that includes analyzing genome databases for Bacillus anthracis and near neighbors, selecting candidate genes encoding potential lytic enzymes based on conserved amino acid motifs as determined in peptidoglycan hydrolases, cloning the candidate genes in expression vector, isolating proteins thereof, and testing for lytic activity against Bacillus anthracis, and selecting an optimum gene of the candidate genes for optimizing lysis conditions.
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