公开(公告)号：US06179865B2

公开(公告)日：2001-01-30

申请号：US09283159

申请日：1999-04-01

申请人： William Hsu ,  Robert J. Sweeney

发明人： William Hsu ,  Robert J. Sweeney

IPC分类号： A61B50464

CPC分类号： A61N1/3622

摘要： A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.

摘要翻译： 用于区分沿逆行方向发生的心律的顺行方向发生的心律的系统和方法。 感测到心房和心室收缩，确定心房和心室周期长度。 还分析心室收缩以确定心房收缩与心室收缩具有一对一关联的心动过速发作的发生。 在心房收缩与心室收缩有一对一关联的心动过速发作期间，心房周期长度与心室周期长度配对，其中对于心房周期长度中的每一个，心房周期长度与至少一个心室 循环长度在每个心房周期长度的第一次心房收缩之前开始，并且与每个心房周期长度的第一次心房收缩之后开始的至少一个心室周期长度配对。 然后确定与在第一次心房收缩之前开始的心室周期长度成对的心房周期长度的逆行相关系数，并且确定与在第一次心房收缩之后开始的心室周期长度配对的心房周期长度的顺行相关系数。 然后根据顺行相关系数与逆行相关系数的比较对心动过速进行分类。

公开(公告)号：US6119043A

公开(公告)日：2000-09-12

申请号：US129348

申请日：1998-08-05

申请人： William Hsu ,  Jay A. Warren ,  Gerrard M. Carlson

发明人： William Hsu ,  Jay A. Warren ,  Gerrard M. Carlson

IPC分类号： A61N1/362 ,  A61N1/00

CPC分类号： A61N1/3622

摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.

摘要翻译： 用于区分来自单个心脏引线的心房和心室信号分量的方法和系统，以及用于将该信息用于将心律失常状态识别为心房或心室起源的方法和系统。 本发明有效地识别出复杂信号中出现的P波，其中包含相对较强的R波或掩蔽P波的其他心室伪像。 通过滤波，时间窗口和传递函数估计得到R波信号对复信号的贡献，然后将R波估计从组合信号中减去离开P波。 可以估计P波与R波，P-P和R-R间隔的比率以及它们彼此之间的比值和固定值，并用于比较以区分心房和心室心律不齐，从而使得能够进行适当的治疗。

公开(公告)号：US5776072A

公开(公告)日：1998-07-07

申请号：US579872

申请日：1995-12-28

申请人： William Hsu ,  Jay A. Warren ,  Gerrard M. Carlson

发明人： William Hsu ,  Jay A. Warren ,  Gerrard M. Carlson

IPC分类号： A61N1/362 ,  A61B5/046

CPC分类号： A61N1/3622

摘要： A method and system for discriminating atrial and ventricular signal components from a single heart lead, and for using this information for identifying an arrhythmia condition as being atrial or ventricular in origin. The invention is effective in identifying P waves occurring in complex signal which includes relatively stronger R waves or other ventricular artifacts which mask the P waves. The contribution of the R wave signal to the complex signal is obtained by filtering, time windowing and transfer function estimation, then the R wave estimate is subtracted from the combined signal to leave the P wave. The ratio of P waves to R waves, P--P and R--R intervals, and their ratios to one another and to fixed values can be estimated, and used in a comparison to discriminate between atrial and ventricular arrhythmia, to thereby enable appropriate treatment.

公开(公告)号：US08214027B2

公开(公告)日：2012-07-03

申请号：US12080891

申请日：2008-04-07

申请人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

发明人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

IPC分类号： A61B5/0464

CPC分类号： A61B5/04525

摘要： A method and system provides for generating a snapshot representative of one beat of a patient's normal cardiac rhythm. Cardiac rate channel signals and shock channel signals are sensed. A fiducial point is determined for a predefined number of the cardiac rate channel signals. A predefined number of the shock channel signals are aligned using the fiducial point. A template is generated using the aligned shock channel signals, whereby the template is representative of one of the patient's normal supra-ventricular conducted cardiac beats. The template is updated on a periodic basis.

摘要翻译： 一种方法和系统提供用于产生代表患者正常心律的一次搏动的快照。 检测心率通道信号和冲击通道信号。 为预定数量的心率通道信号确定基准点。 使用基准点对预定数量的冲击通道信号进行对准。 使用对准的冲击通道信号产生模板，由此模板代表患者的正常心室心脏传出心跳中的一个。 模板定期更新。

公开(公告)号：US20120165884A1

公开(公告)日：2012-06-28

申请号：US12975794

申请日：2010-12-22

申请人： Cecilia Qin Xi ,  Stuart Rosenberg ,  Jong Gill ,  Yelena Nabutovsky ,  William Hsu ,  Brian Jeffrey Wenzel

发明人： Cecilia Qin Xi ,  Stuart Rosenberg ,  Jong Gill ,  Yelena Nabutovsky ,  William Hsu ,  Brian Jeffrey Wenzel

IPC分类号： A61B5/053 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61B5/0538 ,  A61B5/0537 ,  A61B5/4878 ,  A61B5/7239 ,  A61N1/3627 ,  A61N1/36521

摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's fluid accumulation level. A thoracic impedance signal for the patient is obtained. Based on the thoracic impedance signal, a duration metric indicative of a duration of drop of the thoracic impedance signal, a magnitude metric indicative of a magnitude of drop of the thoracic impedance signal, and a rate metric indicative of a rate of drop of the thoracic impedance signal is determined. The patient's fluid accumulation level is monitored based on the duration metric, the magnitude metric and the rate metric.

摘要翻译： 本文提供了可植入系统及其使用的方法，用于监测患者的血液积聚水平。 获得患者的胸部阻抗信号。 基于胸部阻抗信号，指示胸部阻抗信号下降持续时间的持续时间度量，指示胸部阻抗信号的下降幅度的幅度度量，以及指示胸部下降速率的速率度量 确定阻抗信号。 基于持续时间度量，幅度度量和速率度量来监测患者的血液积聚水平。

公开(公告)号：US20120158079A1

公开(公告)日：2012-06-21

申请号：US12975085

申请日：2010-12-21

申请人： Stuart Rosenberg ,  Yelena Nabutovsky ,  Cecilia Qin Xi ,  Jong Gill ,  Kyungmoo Ryu ,  Brian Jeffrey Wenzel ,  William Hsu

发明人： Stuart Rosenberg ,  Yelena Nabutovsky ,  Cecilia Qin Xi ,  Jong Gill ,  Kyungmoo Ryu ,  Brian Jeffrey Wenzel ,  William Hsu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3962

摘要： Techniques are provided for use with an implantable medical device for assessing left ventricular (LV) sphericity and atrial dimensional extent based on impedance measurements for the purposes of detecting and tracking heart failure and related conditions such as volume overload or mitral regurgitation. In some examples described herein, various short-axis and long-axis impedance vectors are exploited that pass through portions of the LV for the purposes of assessing LV sphericity. In other examples, impedance measurements taken along a vector between a right atrial (RA) ring electrode and an LV electrode implanted near the atrioventricular (AV) groove are exploited to assess LA extent, biatrial extent or mitral annular diameter. The assessment techniques can be employed alone or in conjunction with other heart failure detection techniques, such as those based on left atrial pressure (LAP.)

摘要翻译： 提供技术用于可植入医疗装置，用于基于阻抗测量来评估左心室（LV）球形度和心房尺寸范围，以便检测和跟踪心力衰竭和相关状况（例如体积过载或二尖瓣反流）。 在本文描述的一些示例中，为了评估LV球形度的目的，利用穿过LV的部分的各种短轴和长轴阻抗矢量。 在其他示例中，利用沿右心房（RA）环电极和植入在房室（AV）槽附近的LV电极之间的载体进行的阻抗测量来评估LA范围，生物学程度或二尖瓣环直径。 评估技术可以单独使用或与其他心力衰竭检测技术结合使用，例如基于左心房压力（LAP）的那些。

公开(公告)号：US08160389B2

公开(公告)日：2012-04-17

申请号：US12179575

申请日：2008-07-24

申请人： Charles Bissonnette ,  Charles Parker ,  Daniel Cook ,  Douglas Charles Shimonek ,  William Hsu ,  Yin Li

发明人： Charles Bissonnette ,  Charles Parker ,  Daniel Cook ,  Douglas Charles Shimonek ,  William Hsu ,  Yin Li

IPC分类号： G06K9/20 ,  G06K9/34

CPC分类号： G06T11/00

摘要： Image editing tools are commonly used to assist with manipulating and saving visual compositions. Many image editing tools provide slicing functionality to create images slices (sub-images) of the visual composition. As provided herein, a slice representation of a visual composition is defined by an arbitrarily chosen set of coordinates within the visual composition. This slice region may be defined independent of other slice regions (e.g. the slice region may or may not overlap, abut, etc. other slice regions). The slice representation comprises the slice region and one or more objects or portions thereof within the slice region. Slice representations may also comprise overlapping objects and/or slice region coordinates. Objects may be manipulated within a slice representation without affecting that object within other slice representations.

摘要翻译： 图像编辑工具通常用于帮助操纵和保存视觉作品。 许多图像编辑工具提供切片功能来创建视觉构图的图像切片（子图像）。 如本文所提供的，视觉合成的切片表示由视觉合成中的任意选择的坐标系定义。 该切片区域可以独立于其它切片区域（例如切片区域可以重叠，邻接等等等切片区域）而被定义。 切片表示包括切片区域和切片区域内的一个或多个对象或其部分。 切片表示还可以包括重叠对象和/或切片区域坐标。 可以在切片表示内操纵对象，而不会影响其他切片表示中的对象。

公开(公告)号：US20120046566A1

公开(公告)日：2012-02-23

申请号：US13285483

申请日：2011-10-31

申请人： William Hsu

发明人： William Hsu

IPC分类号： A61B5/0464 ,  A61B5/0402 ,  A61B5/0456 ,  A61B5/0452 ,  A61N1/39

CPC分类号： A61B5/0464 ,  A61B5/7264

摘要： A system and method for classifying cardiac complexes sensed during a tachycardia episode. A first cardiac signal and a second cardiac signal are sensed, where the first cardiac signal has a voltage. A first cardiac complex and a second cardiac complex of a cardiac cycle are detected in the first and second cardiac signal, respectively. A predetermined alignment feature is identified in the second cardiac complex. A datum is defined, or positioned, at a specified interval from the predetermined alignment feature of the second cardiac complex. Voltage values are then measured from the first cardiac complex at each of two or more measurement intervals from the datum. The voltage values are then compared voltage values measured from NSR cardiac complexes to classify the first cardiac complex is either a ventricular tachycardia complex or a supraventricular tachycardiac complex.

摘要翻译： 在心动过速发作期间感测到的心脏复合物的分类系统和方法。 感测第一心脏信号和第二心脏信号，其中第一心脏信号具有电压。 分别在第一和第二心脏信号中检测心脏周期的第一心脏复合体和第二心脏复合体。 在第二心脏复合物中识别预定的对准特征。 以与第二心脏复合体的预定对准特征相对的规定间隔定义或定位基准。 然后从基准的两个或更多个测量间隔中的每一个处测量来自第一心脏复合物的电压值。 然后将电压值比较从NSR心脏复合物测量的电压值，以将第一心脏复合物分类为室性心动过速复合物或室上性心动过速复合物。

公开(公告)号：US20090312811A1

公开(公告)日：2009-12-17

申请号：US12546381

申请日：2009-08-24

申请人： William Hsu

发明人： William Hsu

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61B5/0464 ,  A61B5/7264

摘要： A system and method for classifying cardiac complexes sensed during a tachycardia episode. A first cardiac signal and a second cardiac signal are sensed, where the first cardiac signal has a voltage. A first cardiac complex and a second cardiac complex of a cardiac cycle are detected in the first and second cardiac signal, respectively. A predetermined alignment feature is identified in the second cardiac complex. A datum is defined, or positioned, at a specified interval from the predetermined alignment feature of the second cardiac complex. Voltage values are then measured from the first cardiac complex at each of two or more measurement intervals from the datum. The voltage values are then compared voltage values measured from NSR cardiac complexes to classify the first cardiac complex is either a ventricular tachycardia complex or a supraventricular tachycardiac complex.

摘要翻译： 在心动过速发作期间感测到的心脏复合物的分类系统和方法。 感测第一心脏信号和第二心脏信号，其中第一心脏信号具有电压。 分别在第一和第二心脏信号中检测心脏周期的第一心脏复合体和第二心脏复合体。 在第二心脏复合物中识别预定的对准特征。 以与第二心脏复合体的预定对准特征相对的规定间隔定义或定位基准。 然后从基准的两个或更多个测量间隔中的每一个处测量来自第一心脏复合物的电压值。 然后将电压值比较从NSR心脏复合物测量的电压值，以将第一心脏复合物分类为室性心动过速复合物或室上性心动过速复合物。

公开(公告)号：US20080234770A1

公开(公告)日：2008-09-25

申请号：US12080891

申请日：2008-04-07

申请人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

发明人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

IPC分类号： A61N1/39 ,  A61B5/04

CPC分类号： A61B5/04525

摘要： A method and system provides for generating a snapshot representative of one beat of a patient's normal cardiac rhythm. Cardiac rate channel signals and shock channel signals are sensed. A fiducial point is determined for a predefined number of the cardiac rate channel signals. A predefined number of the shock channel signals are aligned using the fiducial point. A template is generated using the aligned shock channel signals, whereby the template is representative of one of the patient's normal supra-ventricular conducted cardiac beats. The template is updated on a periodic basis.