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75 条记录 (耗时 0.019 秒)

    Fetal methylation markers
    72.
    发明申请
    Fetal methylation markers 有权
    胎儿甲基化标记

    公开(公告)号：US20090155776A1

    公开(公告)日：2009-06-18

    申请号：US11784501

    申请日：2007-04-06

    申请人： Yuk Ming Dennis Lo ,  Rossa Wai Kwun Chiu ,  Stephen Siu Chung Chim ,  Chunming Ding ,  Kwan Chee Chan ,  Hing Nam Ivy Wong ,  Ka Chun Ryan Yuen

    发明人： Yuk Ming Dennis Lo ,  Rossa Wai Kwun Chiu ,  Stephen Siu Chung Chim ,  Chunming Ding ,  Kwan Chee Chan ,  Hing Nam Ivy Wong ,  Ka Chun Ryan Yuen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/154 ,  C12Q2600/156

    摘要： This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.

    摘要翻译： 该应用描述了在孕妇中发现来自胎儿的某些基因（如RASSF1A，APC，CASP8，RARB，SCGB3A1，DAB2IP，PTPN6，THY1，TMEFF2和PYCARD）高度甲基化，而相同的基因 产妇来源是未甲基化。 该发现允许从孕妇的生物样品中容易地检测这些甲基化胎儿基因中的一种或多种，​​作为样品中胎儿DNA存在的通用指标。 这些胎儿甲基化标记物作为非侵入性分析过程的阳性对照特别有用，在此过程中监测胎儿DNA的质量和数量。 这些新确定的胎儿标记物也可以直接测量以诊断某些妊娠相关病症。

    Method for diagnosing preeclampsia by detecting hCRH mRNA
    74.
    发明授权
    Method for diagnosing preeclampsia by detecting hCRH mRNA 有权
    通过检测hCRH mRNA诊断先兆子痫的方法

    公开(公告)号：US07235359B2

    公开(公告)日：2007-06-26

    申请号：US10759783

    申请日：2004-01-16

    申请人： Yuk-Ming Dennis Lo ,  Kai On Ng ,  Bo Yin Tsui ,  Wai Kwun Rossa Chiu

    发明人： Yuk-Ming Dennis Lo ,  Kai On Ng ,  Bo Yin Tsui ,  Wai Kwun Rossa Chiu

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclaimpsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin β subunit (hCG-β), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control.

    摘要翻译： 提供方法和试剂盒，用于诊断，监测或预测怀孕妇女的pre-eclaimpsia，胎儿染色体非整倍性和早产儿的状况，以及通过定量测量孕妇血液中的孕妇检测怀孕情况 编码人绒毛膜促性腺激素β亚基（hCG-β），人胎盘乳腺癌（hPL），促皮质激素释放激素（hCRH），KiSS-1转移抑制因子（KISS1），组织因子途径抑制剂2 （TPFI2），胎盘特异性1（PLAC1）或甘油醛-3-磷酸脱氢酶（GAPDH），并将mRNA种类的量与标准对照进行比较。