公开(公告)号：US20070031457A1

公开(公告)日：2007-02-08

申请号：US11173770

申请日：2005-06-30

Applicant: Thomas Dubensky ,  Daniel Portnoy ,  Richard Calendar ,  John Hearst ,  David Cook

Inventor： Thomas Dubensky ,  Daniel Portnoy ,  Richard Calendar ,  John Hearst ,  David Cook

IPC: A61K39/07 ,  C12N1/21

CPC classification number: A61K39/07 ,  A61K2039/522 ,  C12N1/36 ,  C12N9/00 ,  C12N9/14

Abstract: A variety of modified Bacillus anthracis bacteria useful in vaccines are provided. For instance, asporogenic strains of Bacillus anthracis are provided. In addition, Bacillus anthracis strains attenuated in their ability to repair their nucleic acid, such as in their nucleic acid excision repair ability or recombination repair ability, are provided. Strains expressing an antigen, such as protective antigen, under the control of a heterologous promoter and/or an inducible promoter are also provided. Bacillus anthracis bacteria comprising mutations in toxin genes are further provided. Vaccine compositions comprising the bacteria, methods of making the modified strains, and methods of using the vaccines are also provided.

Abstract translation: 提供了用于疫苗的各种改良的炭疽芽孢杆菌。 例如，提供了炭疽芽孢杆菌的异源菌株。 此外，提供了在其核酸修复能力或重组修复能力方面减弱其核酸修复能力的炭疽杆菌菌株。 还提供了在异源启动子和/或诱导型启动子控制下表达抗原（例如保护性抗原）的菌株。 还提供了包含毒素基因突变的炭疽芽孢杆菌。 还提供了包含细菌的疫苗组合物，制备修饰菌株的方法和使用疫苗的方法。

公开(公告)号：US20060289398A1

公开(公告)日：2006-12-28

申请号：US11432282

申请日：2006-05-11

Applicant: David Cook ,  Stephen Liebold ,  Jon Lindsay ,  Zheng Duan

Inventor： David Cook ,  Stephen Liebold ,  Jon Lindsay ,  Zheng Duan

IPC: B23K9/00 ,  B23K9/02

CPC classification number: B23K10/00 ,  H05H1/34 ,  H05H1/3405 ,  H05H2001/3457 ,  H05H2001/3468 ,  H05H2001/3478

Abstract: The invention is generally directed to a nozzle for a plasma torch, the nozzle having a rear portion that defines at least a portion of a plasma chamber and a front portion that includes a first end and a second end. The first end is adjacent the rear portion, and the second end defines a plasma exit portion. One or more fluid passageways are disposed within the front portion and extend from the first end to the second end. The fluid passageways have passageway exit portions that provide one or more discrete jets of a secondary fluid to surround a plasma jet that is ejected from the plasma exit portion. Features of the invention include faster cutting, thicker workpiece piercing capability, reduced noise, improved arc stability, and increased consumable life, all of which improve productivity associated with plasma arc torch workpiece processing.

公开(公告)号：US20060283393A1

公开(公告)日：2006-12-21

申请号：US11348298

申请日：2006-02-06

Applicant: Steve Burghardi ,  Brian Knudson ,  Loren Peterson ,  David Cook ,  Mark Oedekoven

Inventor： Steve Burghardi ,  Brian Knudson ,  Loren Peterson ,  David Cook ,  Mark Oedekoven

IPC: A01K39/00 ,  A01K5/00 ,  A01K61/00

CPC classification number: A01K5/02 ,  A23K20/142 ,  A23K40/00 ,  A23K50/10 ,  A23K50/30 ,  A23K50/80 ,  Y02A40/818

Abstract: A method and system for creating a customized animal feed is disclosed. The method and system include having ingredient data from more than one location, animal data, evaluation data, and optimization weighting data. The specifications for a customized feed are generated using ingredient data representative of the mix of ingredients available at one or more locations. A customized feed is generated which is designed to fulfill the nutritional requirements for the animal's diet. The nutritional requirements are derived from the animal data. Furthermore, the feed is optimized based upon the profile data, the feed data, the evaluation data, and the optimization weighting data.

Abstract translation: 公开了一种用于创建定制的动物饲料的方法和系统。 该方法和系统包括具有多于一个位置的成分数据，动物数据，评估数据和优化加权数据。 使用表示在一个或多个位置可用的成分混合的成分数据生成定制进料的规格。 产生定制的饲料，其被设计为满足动物饮食的营养需求。 营养需求来源于动物数据。 此外，基于简档数据，馈送数据，评估数据和优化加权数据来优化馈送。

公开(公告)号：US20060102598A1

公开(公告)日：2006-05-18

申请号：US10989729

申请日：2004-11-16

Applicant: Peter Twarog ,  Charles Hackett ,  David Cook ,  Bruce Altobelli ,  David Bouthillier

Inventor： Peter Twarog ,  Charles Hackett ,  David Cook ,  Bruce Altobelli ,  David Bouthillier

IPC: B23K9/00

CPC classification number: B23K10/02 ,  H05H1/34 ,  H05H2001/3436 ,  H05H2001/3442 ,  H05H2001/3478

Abstract: An electrode for a plasma arc cutting torch which minimizes the deposition of high emissivity material on the nozzle, reduces electrode wear, and improves cut quality. The electrode has a body having a first end, a second end in a spaced relationship relative to the first end, and an outer surface extending from the first end to the second end. The body has an end face disposed at the second end. The electrode also includes at least one passage extending from a first opening in the body to a second opening in the end face.

Abstract translation: 一种用于等离子体电弧割炬的电极，其使喷嘴上的高辐射率材料的沉积最小化，减少电极磨损并提高切割质量。 电极具有主体，其具有第一端，相对于第一端以间隔开的第二端和从第一端延伸到第二端的外表面。 主体具有设置在第二端的端面。 电极还包括从主体中的第一开口延伸到端面中的第二开口的至少一个通道。

公开(公告)号：US20060041412A1

公开(公告)日：2006-02-23

申请号：US11191236

申请日：2005-07-27

Applicant: Gregory Engelke ,  Steve Burghardi ,  David Cook ,  Donald Giesting ,  Bruce McGoogan ,  Michael Messman ,  Mark Newcomb ,  Jennifer L.G. Ligt

Inventor： Gregory Engelke ,  Steve Burghardi ,  David Cook ,  Donald Giesting ,  Bruce McGoogan ,  Michael Messman ,  Mark Newcomb ,  Jennifer L.G. Ligt

IPC: G06Q99/00 ,  G06G7/48 ,  G06G7/58

CPC classification number: G06Q10/04 ,  A01K5/02 ,  A23K10/00 ,  G06Q10/00 ,  G06Q10/0635 ,  G06Q10/101

Abstract: A system for generating optimized values for variable inputs to an animal production system. The system includes a simulator engine configured to receive a plurality of animal information inputs and generate a performance projection. At least one of the animal information inputs is designated as a variable input. The system further includes an enterprise supervisor engine configured to generate first and second optimized values for the at least one variable input. The first optimized value is generated based on an optimization criteria and the second optimized value is generated based on empirical feedback after application of the first variable input.

Abstract translation: 用于为动物生产系统的可变输入生成优化值的系统。 该系统包括被配置为接收多个动物信息输入并产生性能投影的模拟器引擎。 动物信息输入中的至少一个被指定为可变输入。 该系统还包括被配置为生成用于至少一个可变输入的第一和第二优化值的企业级管理引擎。 基于优化准则生成第一优化值，并且在应用第一变量输入之后基于经验反馈生成第二优化值。

公开(公告)号：US20060041408A1

公开(公告)日：2006-02-23

申请号：US11191255

申请日：2005-07-27

Applicant: Bruce McGoogan ,  Daniel Barziza ,  Steve Burghardi ,  David Cook ,  Gregory Engelke ,  Donald Giesting ,  Michael Messman ,  Mark Newcomb ,  Jennifer Ligt

Inventor： Bruce McGoogan ,  Daniel Barziza ,  Steve Burghardi ,  David Cook ,  Gregory Engelke ,  Donald Giesting ,  Michael Messman ,  Mark Newcomb ,  Jennifer Ligt

IPC: G06G7/48

CPC classification number: G06Q10/04 ,  A01K5/02 ,  A23K10/00 ,  G06Q10/00 ,  G06Q10/0635 ,  G06Q10/101

Abstract: A system for generating an animal feed formulation based on environmental nutrient inputs. The system comprises a simulator engine configured to generate a set of animal requirements in view of environmental nutrients received by an animal based on characteristics of the animal and a formulator engine configured to receive the set of animal requirements and generate an optimized animal feed formulation based on the animal requirements.

Abstract translation: 一种基于环境营养投入产生动物饲料配方的系统。 该系统包括模拟器引擎，其被配置为考虑到基于动物的特征的动物接收的环境营养物产生一组动物需求，配制器引擎被配置为接收一组动物需求并且基于 动物要求。

公开(公告)号：US20050251428A1

公开(公告)日：2005-11-10

申请号：US10911324

申请日：2004-08-04

Applicant: Larry Dust ,  David Cook ,  Wallace Gray ,  Hans Kraabel

Inventor： Larry Dust ,  David Cook ,  Wallace Gray ,  Hans Kraabel

IPC: G06Q10/00 ,  G06F17/60

CPC classification number: G06Q10/00 ,  G06Q40/00 ,  G06Q40/08

Abstract: A method and system for providing healthcare benefits according to the present invention may include a proposed healthcare plan having a primary component, a supplemental component, and a procedure for optimizing services consumption which is presented and customized “on-the-fly” to benefits providers, such as employers, and administered in an efficient manner that reduces the claims processing burden on individuals or families covered under the proposed plan.

Abstract translation: 根据本发明的用于提供医疗益处的方法和系统可以包括具有主要部件，补充部件和优化服务消耗的程序的提议的医疗保健计划，其被“动态地”呈现和定制以使受益者得到 ，如雇主，并以有效的方式进行管理，以减少对拟议计划所涵盖的个人或家庭的索赔处理负担。

公开(公告)号：US20050156926A1

公开(公告)日：2005-07-21

申请号：US11081320

申请日：2005-03-16

Applicant: Adityo Prakash ,  Eniko Fodor ,  Edward Ratner ,  David Cook

Inventor： Adityo Prakash ,  Eniko Fodor ,  Edward Ratner ,  David Cook

IPC: G06T7/60 ,  G06T7/00 ,  G06T7/20 ,  G06T15/40

CPC classification number: G06T7/579

Abstract: In one embodiment according to the present invention, relative z-ordering of segments in a digital image is determined. A method comprises forward and backward motion matching of image regions to determine overlap, followed by the creation of relationships (e.g., pairwise relationships) between regions and comparing the result with the original image to determine the relative z-ordering.

Abstract translation: 在根据本发明的一个实施例中，确定数字图像中段的相对z-排列。 一种方法包括图像区域的向前和向后运动匹配以确定重叠，随后在区域之间建立关系（例如，成对关系），并将结果与​​原始图像进行比较以确定相对z排序。

公开(公告)号：US20050067387A1

公开(公告)日：2005-03-31

申请号：US10957478

申请日：2004-09-30

Applicant: David Cook ,  Kirk Ferland ,  Charles Hackett ,  Yong Yang ,  Richard Couch ,  Zhipeng Lu

Inventor： David Cook ,  Kirk Ferland ,  Charles Hackett ,  Yong Yang ,  Richard Couch ,  Zhipeng Lu

IPC: B23K10/02 ,  H05B7/07 ,  H05B7/18 ,  H05H1/34 ,  B23K10/00

CPC classification number: H05H1/34 ,  H05H2001/3436 ,  H05H2001/3442

Abstract: A plasma arc torch that includes a torch body having a nozzle mounted relative to a composite electrode in the body to define a plasma chamber. The torch body includes a plasma flow path for directing a plasma gas to the plasma chamber in which a plasma arc is formed. The nozzle includes a hollow, body portion and a substantially solid, head portion defining an exit orifice. The composite electrode can be made of a metallic material (e.g., silver) with high thermal conductivity in the forward portion electrode body adjacent the emitting surface, and the aft portion of the electrode body is made of a second low cost, metallic material with good thermal and electrical conductivity. This composite electrode configuration produces an electrode with reduced electrode wear or pitting comparable to a silver electrode, for a price comparable to that of a copper electrode.

Abstract translation: 一种等离子弧焊炬，其包括具有相对于主体中的复合电极安装的喷嘴的炬体，以限定等离子体室。 手电筒包括用于将等离子体气体引导到形成等离子体电弧的等离子体室的等离子体流动路径。 喷嘴包括中空的主体部分和限定出口的基本上固体的头部。 复合电极可以由邻近发射表面的前部电极体中具有高导热性的金属材料（例如银）制成，并且电极体的后部由具有良好的第二低成本金属材料制成 导热和导电性。 这种复合电极配置产生与电极相当的电极磨损或点蚀的电极，其价格与铜电极相当。

公开(公告)号：US06709810B2

公开(公告)日：2004-03-23

申请号：US09912031

申请日：2001-07-23

Applicant: David Cook ,  Adonis Stassinopoulos

Inventor： David Cook ,  Adonis Stassinopoulos

IPC: A01N102

CPC classification number: A61L2/0088

Abstract: Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. Biological materials which may be treated include whole blood, red blood cells, blood plasma, and platelets. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.

Abstract translation: 提供了用于猝灭病原体灭活化合物在生物材料中的不希望的副反应的方法。 在一个具体实施方案中，提供了用于猝灭病原体灭活化合物的不希望的副反应的方法，其包括可亲电子基团或能够形成亲电基团的官能团。 在该实施方案中，用病原体灭活化合物和猝灭剂处理材料，其中猝灭剂包含能够与亲电子基团共价反应的亲核官能团。 病原体灭活化合物上的亲电基团优选为非自由基阳离子基团。 在一个实施方案中，病原体灭活化合物包括核酸结合配体和芥子基团，其中芥末基团能够在原位反应形成亲电子基团。 优选的猝灭剂是硫醇，如谷胱甘肽。 可以治疗的生物材料包括全血，红细胞，血浆和血小板。 该方法允许在病原体灭活期间抑制含红细胞的材料中的红细胞的修饰。