公开(公告)号：US20060134349A1

公开(公告)日：2006-06-22

申请号：US11216628

申请日：2005-08-31

Applicant: Krishnan Chari ,  John Kowalczyk ,  Charles Rankin ,  Erica Montbach

Inventor： Krishnan Chari ,  John Kowalczyk ,  Charles Rankin ,  Erica Montbach

IPC: C09K19/02 ,  C09K19/52 ,  C09K19/54 ,  G02F1/1333

CPC classification number: G02F1/1334 ,  G02F1/133305 ,  G02F1/13718 ,  G02F2001/13345 ,  G02F2202/38 ,  Y10T428/10 ,  Y10T428/1005

Abstract: The present invention relates to a high contrast reflective display comprising at least one substrate, at least one electrically conductive layer and at least one close-packed, ordered monolayer of domains of electrically modulated material in a fixed, preferably crosslinked, polymer matrix and a method of making the same.

Abstract translation: 本发明涉及一种高对比度反射显示器，其包括至少一个基板，至少一个导电层和至少一个紧密堆积的有序单层的固定，优选交联的聚合物基质中的电调制材料的结构域，以及方法 做同样的事情

公开(公告)号：US07011945B2

公开(公告)日：2006-03-14

申请号：US10036828

申请日：2001-12-21

Applicant: Tiecheng A. Qiao ,  Krishnan Chari ,  Douglas L. Vizard

Inventor： Tiecheng A. Qiao ,  Krishnan Chari ,  Douglas L. Vizard

IPC: C12Q1/68 ,  C12M1/36 ,  C07H21/04

CPC classification number: B01J19/0046 ,  B01J2219/00466 ,  B01J2219/00529 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00702 ,  G06F19/20

Abstract: A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid containing a gelling agent or a precursor to a gelling agent and immobilized at random positions on the substrate, at least one sub-population of said population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting said array with a target nucleic acid sequence; and detecting the color barcode of said sub-population of micro-spheres due to the interaction of said probe nucleic acid sequence and said target nucleic acid sequence.

公开(公告)号：US20050264725A1

公开(公告)日：2005-12-01

申请号：US10853884

申请日：2004-05-25

Applicant: Krishnan Chari ,  Charles Rankin

Inventor： Krishnan Chari ,  Charles Rankin

IPC: G02F1/1334 ,  G02F1/137 ,  G02F1/1335

CPC classification number: G02F1/1334 ,  G02F1/13718

Abstract: A display sheet is disclosed comprising, a substrate, first transparent conductors, second conductors and, between first and second conductors, at least one imaging layer comprising a substantial monolayer of isolated domains of liquid-crystal material, dispersed in a continuous matrix, wherein said domains of liquid-crystal material comprises a mixture of at least two populations, a first population comprising a first liquid-crystal material having a first λmax within the infrared spectral region and a second population comprising a second liquid-crystal material having a second λmax within the visible spectral region. Alternately, the imaging layer can comprise a substantial monolayer of isolated domains of liquid-crystal material comprising a population of domains comprising a liquid-crystal material having a λmax between 700 and 800 and having a half-peak width that extends into both the visible spectrum region and the infrared spectral region.

Abstract translation: 公开了一种显示片，其包括：衬底，第一透明导体，第二导​​体，以及在第一和第二导体之间的至少一个成像层，其包含分散在连续矩阵中的液晶材料隔离畴的实质单层，其中所述 液晶材料的结构域包括至少两个群体的混合物，第一群体包括在红外光谱区域内具有第一λ最大值的第一液晶材料和包含第二液体的第二群体 在可见光谱区内具有第二λ最大值的晶体材料。 或者，成像层可以包括液晶材料的分离域的实质单层，其包含一组结构域，所述结构域包括具有700-800之间的λ最大值的具有半峰的液晶材料 宽度延伸到可见光谱区域和红外光谱区域。

公开(公告)号：US06916620B2

公开(公告)日：2005-07-12

申请号：US10098642

申请日：2002-03-15

Applicant: Tiecheng A. Qiao ,  Krishnan Chari ,  Douglas L. Vizard

Inventor： Tiecheng A. Qiao ,  Krishnan Chari ,  Douglas L. Vizard

IPC: G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  C40B40/06 ,  C40B70/00 ,  G01N37/00 ,  C07H21/04 ,  C12M1/36 ,  C12N11/16 ,  G01N15/06

CPC classification number: C12Q1/6837 ,  B01J2219/00466 ,  B01J2219/00545 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00722 ,  C40B40/06 ,  C40B70/00 ,  C12Q2565/513 ,  C12Q2565/102 ,  C12Q2563/149

Abstract: A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to a gelling agent, wherein a first portion of the micro-spheres is submerged in the gelatin coating and a second portion is exposed above the gelatin coating and is substantially free of gelatin, at least one sub-population of the population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting the array with a target nucleic acid sequence; and detecting the color barcode of the sub-population of micro-spheres due to the interaction of the probe nucleic acid sequence and the fluorescently/chemiluminescently labeled nucleic acid sample target nucleic acid sequence.

Abstract translation: 一种鉴定核酸样品的方法，包括：提供包含底物的微阵列，所述底物涂覆有组合物，所述组合物包含固定在包含胶凝剂或胶凝剂前体的涂层中的核酸探针修饰微球体群体，其中第一部分 的微球浸没在明胶涂层中，第二部分暴露在明胶涂层上方并且基本上不含明胶，至少一个群体微球的亚群包含由至少一种着色剂产生的光学条形码 与微球相关并包括核酸探针序列; 使阵列与靶核酸序列接触; 并且由于探针核酸序列和荧光/化学发光标记的核酸样品靶核酸序列的相互作用，检测微球子群体的颜色条形码。

公开(公告)号：US20050106712A1

公开(公告)日：2005-05-19

申请号：US10713246

申请日：2003-11-14

Applicant: Krishnan Chari ,  Tiecheng Qiao ,  Donald Diehl ,  Samuel Chen

Inventor： Krishnan Chari ,  Tiecheng Qiao ,  Donald Diehl ,  Samuel Chen

IPC: B01L99/00 ,  C07C251/08 ,  C07D295/185 ,  C12M1/34 ,  C07C251/54

CPC classification number: C07D295/185 ,  C07C251/08

Abstract: A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent and microspheres; the microspheres containing a dye represented by Formula (I): wherein: R1 and R2 independently reprresent substituted or unsubstituted alkyl, aryl, carbocyclic ring, heterocyclic ring, or amino; and R3 represents H, alkylamino, dialkylamino, hydroxy, or alkoxy.

Abstract translation: 一种用于制备蛋白质微阵列的涂料组合物，所述组合物包含胶凝剂或胶凝剂的前体和微球体; 所述微球含有由式（I）表示的染料：其中：R 1和R 2独立地表示取代或未取代的烷基，芳基，碳环，杂环或氨基; R3表示H，烷基氨基，二烷基氨基，羟基或烷氧基。

公开(公告)号：US20050106711A1

公开(公告)日：2005-05-19

申请号：US10713165

申请日：2003-11-14

Applicant: Krishnan Chari ,  Tiecheng Qiao ,  Donald Diehl ,  Samuel Chen

Inventor： Krishnan Chari ,  Tiecheng Qiao ,  Donald Diehl ,  Samuel Chen

IPC: B01J19/00 ,  C07C251/14 ,  C07H21/04 ,  C09B55/00 ,  C12M1/34 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00

CPC classification number: C09B55/009 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00

Abstract: A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent and microspheres; the microspheres containing a dye represented by Formula (I): wherein: R1 is one or more substituents selected from the group consisting of H, Cl, Br, I, substituted or unsubstituted alkyl, alkylamino, arylamino, acyl, nitrile, alkoxy, aryl, heteroaryl, sulfone, sulfamoyl, sulfonamido, or substituted or unsubstituted amido; and R2 and R3 are independently H, substituted amino, alkoxy, substituted or unsubstituted alkyl, substituted amido, or Cl.

Abstract translation: 一种用于制备蛋白质微阵列的涂料组合物，所述组合物包含胶凝剂或胶凝剂的前体和微球体; 含有由式（I）表示的染料的微球：其中：R 1是一个或多个选自H，Cl，Br，I，取代或未取代的烷基，烷基氨基，芳基氨基，酰基，腈，烷氧基，芳基 ，杂芳基，砜，氨磺酰基，亚磺酰氨基或取代或未取代的酰氨基; 并且R 2和R 3独立地为H，取代的氨基，烷氧基，取代或未取代的烷基，取代的酰氨基或Cl。

公开(公告)号：US06797393B2

公开(公告)日：2004-09-28

申请号：US10020747

申请日：2001-11-30

Applicant: Tiecheng A. Qiao ,  Krishnan Chari ,  Thomas L. Penner ,  Zhihao Yang

Inventor： Tiecheng A. Qiao ,  Krishnan Chari ,  Thomas L. Penner ,  Zhihao Yang

IPC: B32B902

CPC classification number: B82Y30/00 ,  B01J2219/00274 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00725 ,  C40B40/10 ,  G01N33/54353 ,  Y10T428/31504 ,  Y10T428/31768

Abstract: A gelatin-based substrate for fabricating protein arrays, the substrate containing: gelatin and a trifunctional compound A—L—B; wherein A is a functional group capable of interacting with the gelatin; L is a linking group capable of interacting with A and with B; and B is a functional group capable of interacting with a protein capture agent. A may be the same or different from B.

Abstract translation: 用于制造蛋白质阵列的明胶基底物，所述基质含有：明胶和三官能化合物A-L-B; 其中A是能够与明胶相互作用的官能团; L是能够与A和B相互作用的连接基团; 并且B是能够与蛋白质捕获剂相互作用的官能团。 A可能与B相同或不同。

公开(公告)号：US06649312B1

公开(公告)日：2003-11-18

申请号：US10171012

申请日：2002-06-12

Applicant: Krishnan Chari ,  Richard P. Szajewski ,  Lyn M. Irving

Inventor： Krishnan Chari ,  Richard P. Szajewski ,  Lyn M. Irving

IPC: G03C302

CPC classification number: G03C1/7614 ,  G03C7/14 ,  G03C7/3029 ,  Y10S430/147

Abstract: Disclosed is light sensitive element comprising a support, at least one light sensitive silver halide emulsion layer, and a micro-bead layer comprising micro-beads a wherein the quantity of binder in the micro-bead layer is such that the micro-beads are not fully enclosed by the binder, thereby enabling the beads to function as microlenses. The invention also provides a camera combination and imaging method. Embodiments of the invention provide improved sensitivity and latitude in scene exposure range.

Abstract translation: 公开了包含载体，至少一种感光卤化银乳剂层和包含微珠a的微珠层的光敏元件，其中微珠层中的粘合剂的量使得微珠不是 完全被粘合剂包围，从而使珠粒起微透镜的作用。 本发明还提供一种相机组合和成像方法。 本发明的实施例在场景曝光范围内提供了改进的灵敏度和纬度。

公开(公告)号：US06602656B1

公开(公告)日：2003-08-05

申请号：US10225608

申请日：2002-08-22

Applicant: Joel D. Shore ,  Krishnan Chari ,  Dennis R. Perchak

Inventor： Joel D. Shore ,  Krishnan Chari ,  Dennis R. Perchak

IPC: G02B520

CPC classification number: G03C7/12 ,  G02B5/201

Abstract: Disclosed is an imaging element comprising a single layer containing a random distribution of a colored bead population of one or more colors coated above one or more layers comprising light sensitive silver halide emulsion grains, wherein the population comprises beads of at least one color in which at least 25% (based on projected area) of the beads of that color have an ECD less than 2 times the ECD of the silver halide grains in said one emulsion layer or in the fastest emulsion layer in the case of more than one emulsion layer

Abstract translation: 公开了一种成像元件，其包含含有包含感光卤化银乳剂颗粒的一层或多层上涂覆的一种或多种颜色的着色珠粒群的随机分布的单层，其中所述群体包含至少一种颜色的珠粒，其中 该颜色的珠粒的至少25％（基于投影面积）的ECD小于所述一个乳剂层中的卤化银颗粒的ECD的2倍或在超过一个乳剂层的情况下在最快的乳剂层中的ECD

公开(公告)号：US06599668B2

公开(公告)日：2003-07-29

申请号：US09923245

申请日：2001-08-03

Applicant: Krishnan Chari ,  John C. Kowalczyk

Inventor： Krishnan Chari ,  John C. Kowalczyk

IPC: G02B520

CPC classification number: G03C7/08

Abstract: Disclosed is process for forming a color filter array layer on a transparent surface, comprising the step of applying a water-borne solid-particle dispersion of randomly disposed colored beads of a water-immiscible synthetic polymer to the surface.

Abstract translation: 公开了一种在透明表面上形成滤色器阵列层的方法，包括将表面上与水不混溶的合成聚合物的随机涂布的有色珠粒的水性固体 - 颗粒分散体施加到步骤。