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公开(公告)号：US07011945B2
公开(公告)日：2006-03-14
申请号：US10036828
申请日：2001-12-21
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/00529 , B01J2219/00545 , B01J2219/00547 , B01J2219/00576 , B01J2219/00648 , B01J2219/00702 , G06F19/20
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid containing a gelling agent or a precursor to a gelling agent and immobilized at random positions on the substrate, at least one sub-population of said population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting said array with a target nucleic acid sequence; and detecting the color barcode of said sub-population of micro-spheres due to the interaction of said probe nucleic acid sequence and said target nucleic acid sequence.
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2.发明授权公开(公告)号：US06916620B2
公开(公告)日：2005-07-12
申请号：US10098642
申请日：2002-03-15
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B70/00 , G01N37/00 , C07H21/04 , C12M1/36 , C12N11/16 , G01N15/06
CPC分类号： C12Q1/6837 , B01J2219/00466 , B01J2219/00545 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , C12Q2565/513 , C12Q2565/102 , C12Q2563/149
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to a gelling agent, wherein a first portion of the micro-spheres is submerged in the gelatin coating and a second portion is exposed above the gelatin coating and is substantially free of gelatin, at least one sub-population of the population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting the array with a target nucleic acid sequence; and detecting the color barcode of the sub-population of micro-spheres due to the interaction of the probe nucleic acid sequence and the fluorescently/chemiluminescently labeled nucleic acid sample target nucleic acid sequence.
摘要翻译： 一种鉴定核酸样品的方法，包括：提供包含底物的微阵列，所述底物涂覆有组合物，所述组合物包含固定在包含胶凝剂或胶凝剂前体的涂层中的核酸探针修饰微球体群体，其中第一部分 的微球浸没在明胶涂层中，第二部分暴露在明胶涂层上方并且基本上不含明胶，至少一个群体微球的亚群包含由至少一种着色剂产生的光学条形码 与微球相关并包括核酸探针序列; 使阵列与靶核酸序列接触; 并且由于探针核酸序列和荧光/化学发光标记的核酸样品靶核酸序列的相互作用，检测微球子群体的颜色条形码。
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公开(公告)号：US07108891B2
公开(公告)日：2006-09-19
申请号：US10092803
申请日：2002-03-07
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00545 , B01J2219/00554 , B01J2219/00596 , B01J2219/00639 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： A method of making a microarray comprising the steps of: providing a support; coating on the support a receiving layer to receive microspheres, the receiving layer being capable of undergoing sol/gel transition; coating on the receiving layer a dispersion of microspheres in a carrier fluid, wherein the carrier fluid contains at least one crosslinking agent and is capable of solvating the receiving layer; allowing the microspheres to partially submerge into the receiving layer; creating conditions to induce sol/gel transition in the receiving layer, thus immobilizing the microspheres; evaporating off the carrier fluid; and allowing crosslinking reaction between the receiving layer and the crosslinker in the carrier fluid.
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4.发明申请MAGENTA LOW FLUORESCENCE DYE FOR COATED OPTICAL BEAD RANDOM ARRAY DNA ANALYSIS 审中-公开用于涂层光束随机阵列DNA分析的MAGENTA低荧光染料公开(公告)号：US20080125331A1
公开(公告)日：2008-05-29
申请号：US11945484
申请日：2007-11-27
申请人： Krishnan Chari , Tiecheng A. Qiao , Donald R. Diehl , Samuel Chen , Kevin W. Williams , David A. Stegman
发明人： Krishnan Chari , Tiecheng A. Qiao , Donald R. Diehl , Samuel Chen , Kevin W. Williams , David A. Stegman
CPC分类号： C09B45/48 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00648 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C08K5/0091 , C08K5/22 , C08K5/3437 , C08K9/10 , C08L25/06 , C09B67/0097 , C09D7/41 , C09D7/69 , C09D7/70
摘要： A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent, and microspheres; the microspheres containing a dye represented by the Formula (1): wherein: R1=one or more substitutent selected from the group of H, chloro, alkoxycarbonyl, arylsulfamoyl, or alkylsulfamoyl; R2=one or more substituent selected from the group of H, carboxamido, or alkoxycarbonyl; R3=one or more substituent selected from the group of H, chloro, substituted or unsubstituted alkyl, aryl, carboxamido, or alkoxycarbonyl.
摘要翻译： 一种用于制备蛋白质微阵列的组合物，所述组合物包含胶凝剂或胶凝剂的前体，和微球; 含有由式（1）表示的染料的微球体：其中：R1 =选自H，氯，烷氧基羰基，芳基氨磺酰基或烷基氨磺酰基的一种或多种取代基; R2 =选自H，甲酰氨基或烷氧基羰基的一个或多个取代基; R3 =一个或多个选自H，氯，取代或未取代的烷基，芳基，甲酰胺基或烷氧基羰基的取代基。
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公开(公告)号：US06797393B2
公开(公告)日：2004-09-28
申请号：US10020747
申请日：2001-11-30
IPC分类号： B32B902
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00725 , C40B40/10 , G01N33/54353 , Y10T428/31504 , Y10T428/31768
摘要： A gelatin-based substrate for fabricating protein arrays, the substrate containing: gelatin and a trifunctional compound A—L—B; wherein A is a functional group capable of interacting with the gelatin; L is a linking group capable of interacting with A and with B; and B is a functional group capable of interacting with a protein capture agent. A may be the same or different from B.
摘要翻译： 用于制造蛋白质阵列的明胶基底物，所述基质含有：明胶和三官能化合物A-L-B; 其中A是能够与明胶相互作用的官能团; L是能够与A和B相互作用的连接基团; 并且B是能够与蛋白质捕获剂相互作用的官能团。 A可能与B相同或不同。
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公开(公告)号：US07011971B2
公开(公告)日：2006-03-14
申请号：US10062326
申请日：2002-06-03
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/00495 , B01J2219/005 , B01J2219/00545 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , C40B60/14 , C40B70/00
摘要： A method of making a microarray comprising the steps of:—providing a support;—coating on the support a fluid composition containing microspheres and gelatin;—immobilizing the microspheres in the gelatin coating;—partially digesting the gelatin with an enzyme to expose surfaces of the microspheres; and—removing the enzyme and digested gelatin from the coating.
摘要翻译： 一种制备微阵列的方法，其包括以下步骤： - 提供载体; - 在所述载体上涂覆含有微球和明胶的流体组合物; - 将所述微球体在所述明胶涂层中进行移动; - 用酶对所述明胶进行部分消化以暴露 微球; 并从涂层中除去酶和消化的明胶。
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公开(公告)号：US06947142B2
公开(公告)日：2005-09-20
申请号：US10606621
申请日：2003-06-26
CPC分类号： G01N21/251
摘要： A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, at least one of which has a color characteristic; capturing the microarray with an electronic color image sensor assembly having a matrix of pixels to produce an electronic microarray image; detecting the location of a microsphere within the captured microarray image; and identifying a color characteristic of the detected microsphere.
摘要翻译： 一种确定着色微球的一种或多种颜色特性的方法，包括：提供微球的微阵列，其中至少一种具有颜色特征; 用具有像素矩阵的电子彩色图像传感器组件捕获微阵列，以产生电子微阵列图像; 检测捕获的微阵列图像内的微球的位置; 并识别检测到的微球的颜色特性。
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8.发明授权Color detection using spectroscopic imaging and processing in random array of microspheres 失效使用随机阵列的微球的光谱成像和处理进行颜色检测公开(公告)号：US07034941B2
公开(公告)日：2006-04-25
申请号：US10607146
申请日：2003-06-26
申请人： Samuel Chen , Anthony E. Taddei , Joaquin Calcines , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard
发明人： Samuel Chen , Anthony E. Taddei , Joaquin Calcines , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard
IPC分类号： G01J3/46
CPC分类号： G01N33/54313 , G01N33/582 , G01N33/583
摘要： A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, including at least one colored microsphere which has a color characteristic; producing a magnified optical image of individual microspheres of the microarray; locating a microsphere in the aperture of a spectrometer to confine the color region of interest of the located microsphere in order to determine one or more color characteristics thereof; and determining one or more color characteristics of the located microsphere by means of the spectrometer.
摘要翻译： 确定着色微球的一种或多种颜色特性的方法，包括：提供微球的微阵列，所述微球包括至少一种具有颜色特征的有色微球; 产生微阵列的单个微球的放大的光学图像; 将微球定位在光谱仪的孔中以限制所定位的微球的感兴趣的颜色区域，以便确定其一个或多个颜色特性; 并通过光谱仪确定所定位的微球的一种或多种颜色特性。
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公开(公告)号：US10265263B2
公开(公告)日：2019-04-23
申请号：US14344774
申请日：2012-09-13
IPC分类号： A61K8/81 , C08K3/20 , C09K8/035 , C09K8/60 , C09K8/68 , A61K8/04 , A61K8/42 , A61K8/46 , A61Q19/00 , C08K5/20 , C08K5/41 , C09K8/12 , C09K8/80 , A61K8/84
摘要： A stable, aqueous composition containing a crosslinked, nonionic, amphiphilic polymer capable of forming a yield stress fluid in the presence of a surfactant is disclosed. The yield stress fluid is capable of suspending insoluble materials in the form of particulates and/or droplets requiring suspension or stabilization.
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10.发明授权公开(公告)号：US07704568B2
公开(公告)日：2010-04-27
申请号：US12331773
申请日：2008-12-10
申请人： Deepak Shukla , Krishnan Chari
发明人： Deepak Shukla , Krishnan Chari
CPC分类号： C09K19/586 , C09K19/588 , Y10T428/10 , Y10T428/1036 , Y10T428/1055
摘要： The present invention relates to photo-tunable dopant compositions comprising a photo-reactive chiral compound capable of undergoing a photochemical reaction resulting in the loss of chirality, and a triplet sensitizer. The present invention also relates to a display comprising a substrate, a liquid crystalline layer thereon, wherein the liquid crystalline layer comprises a nematic host, at least one chiral dopant, a photo-reacted compound, and a triplet sensitizer, and at least one transparent conductive layer. The present invention also relates to a method of tuning a cholesteric liquid crystal material comprising providing at least one mesogenic compound, at least one triplet sensitizer, and at least one photo-reactive chiral compound; combining the at least one mesogenic compound, at least one triplet sensitizer, and at least one photo-reactive chiral compound to form a mixture; and irradiating the mixture for a period of time.
摘要翻译： 本发明涉及光可掺杂掺杂剂组合物，其包含能够经历导致手性丧失的光化学反应的光反应性手性化合物和三线态敏化剂。 本发明还涉及一种显示器，其包括基底，其上的液晶层，其中所述液晶层包括向列型主体，至少一种手性掺杂剂，光反应化合物和三线态敏化剂，以及至少一种透明 导电层。 本发明还涉及一种调节胆甾型液晶材料的方法，包括提供至少一种介晶化合物，至少一种三线态敏化剂和至少一种光反应性手性化合物; 组合所述至少一种介晶化合物，至少一种三线态敏化剂和至少一种光反应性手性化合物以形成混合物; 并将混合物照射一段时间。
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