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公开(公告)号：US4016880A
公开(公告)日：1977-04-12
申请号：US663665
申请日：1976-03-04
CPC分类号： A61K9/0004 , A61F9/0017
摘要： Osmotically driven active agent dispenser for use in an aqueous environment that pumps a solution of active agent, such as a drug, at a predetermined, constant rate. The dispenser is in the form of a coated tablet comprising: a core of an osmotically effective active agent composition; and an inexpandable wall that encloses the core, has a controlled permeability to water and includes means, such as brittleness or sites of structural weakness, that is responsive to the pressure generated within the dispenser by imbibition of water from the environment by the core through the wall to form at least one, and usually many, passageways in situ in the wall through which the active agent composition in solution is pumped osmotically at a rate that is substantially dependent of the rate at which water is being imbibed into the dispenser.
摘要翻译： 渗透驱动的活性剂分配器，用于以预定的恒定速率泵送活性剂如药物的溶液的水性环境。 分配器是包衣片剂的形式，包括：渗透有效的活性剂组合物的核心; 并且包围核心的廉价的壁具有受控的水渗透性，并且包括诸如脆性或结构弱点的装置，该装置通过由核心通过芯部吸收来自环境的水来响应分配器内产生的压力 壁在壁中原位形成至少一个通常多个通道，通过该通道，溶液中的活性剂组合物通过渗透液体以基本上取决于水被吸入分配器的速率的速率被泵送。
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72.发明授权Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method 失效流体输送装置具有带有阴离子交换膜的电化学泵和相关方法公开(公告)号：US07470267B2
公开(公告)日：2008-12-30
申请号：US10137661
申请日：2002-05-01
IPC分类号： A61K9/22
CPC分类号： A61M5/1452 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513
摘要： A fluid delivery device, comprising an electrochemical pump, wherein the pump is capable of transporting water; a pump product chamber, wherein the pump product chamber is capable of retaining water generated from the pump; a displaceable member positioned between the pump product chamber and a reservoir, wherein the displaceable member is controllably displaced upon generation of water from the electrochemical pump; a reservoir, wherein the reservoir is capable of containing a fluid which is delivered upon displacement of the displaceable member; and an housing for containing the pump, the pump product chamber, the displaceable member, and the reservoir.
摘要翻译： 一种流体输送装置，包括电化学泵，其中所述泵能够输送水; 泵产品室，其中所述泵产品室能够保留从所述泵产生的水; 定位在所述泵产品室和储存器之间的可移位构件，其中所述可移位构件在从所述电化学泵产生水时可控地移位; 储存器，其中所述储存器能够容纳在所述可移位构件移位时被输送的流体; 以及用于容纳泵，泵产品室，可移动构件和储存器的壳体。
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公开(公告)号：US07438701B2
公开(公告)日：2008-10-21
申请号：US09917181
申请日：2001-07-26
申请人： Felix Theeuwes , Su Il Yum
发明人： Felix Theeuwes , Su Il Yum
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译： 本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。 对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。 稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。 稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。
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公开(公告)号：US07371229B2
公开(公告)日：2008-05-13
申请号：US10353769
申请日：2003-01-28
IPC分类号： A61K9/22
CPC分类号： H01M2/0202 , A61M2005/14513 , A61N1/30 , B01D61/427 , H01M10/425 , H01M10/484
摘要： The present invention is disclosed herein as an electrochemical cell having a cell housing with a first half cell and a second half cell, and an ion selective membrane between the cells. The electrochemical cell further has a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with both the first electrode and the second electrode. The electrodes of the cell are configured so that the electrochemical cell maintains a substantially constant salt concentration level throughout operation. The cell is preferably used in conjunction with an implantable fluid delivery apparatus. A method for using the device is additionally disclosed.
摘要翻译： 本发明在此被公开为具有具有第一半电池和第二半电池的电池壳体的电化学电池以及电池之间的离子选择性膜。 电化学电池还具有位于第一半单元内的第一电极，位于第二半单元内的第二电极，与第一电极和第二电极电连通的电解质。 电池的电极被配置为使得电化学电池在整个操作中保持基本上恒定的盐浓度水平。 细胞优选与可植入流体输送装置结合使用。 另外公开了一种使用该装置的方法。
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公开(公告)号：US06918901B1
公开(公告)日：2005-07-19
申请号：US08988292
申请日：1997-12-10
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/0046
摘要： An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.
摘要翻译： 一种药剂输送或取样装置（2），包括具有用于刺穿皮肤的多个叶片（4）的构件（6）和覆盖该构件的皮肤接触侧（48）的至少一部分的连接介质 （6）用于增加药剂的经皮通量。
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公开(公告)号：US20050126912A1
公开(公告)日：2005-06-16
申请号：US10906433
申请日：2005-02-18
申请人： Felix Theeuwes , Jeremy Wright
发明人： Felix Theeuwes , Jeremy Wright
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译： 公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极 位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于 在电渗透细胞内抵消盐浓度增加。 这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口 港口。 类似地公开了使用这种装置的方法。
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公开(公告)号：US06872292B2
公开(公告)日：2005-03-29
申请号：US10353770
申请日：2003-01-28
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译： 公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极 位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于 在电渗透细胞内抵消盐浓度增加。 这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口 港口。 类似地公开了使用这种装置的方法。
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公开(公告)号：US06544252B1
公开(公告)日：2003-04-08
申请号：US09472600
申请日：1999-12-27
申请人： Felix Theeuwes , Ben Eckenhoff
发明人： Felix Theeuwes , Ben Eckenhoff
IPC分类号： A61K922
CPC分类号： A61K9/0004
摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The moveable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.
摘要翻译： 具有空间高效活塞的渗透输送系统。 胶囊具有保持活塞的内部，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂通过半透水体吸收来自周围环境的液体，引起活塞移动，从而导致有益剂从胶囊的输送。
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公开(公告)号：US06368315B1
公开(公告)日：2002-04-09
申请号：US09339465
申请日：1999-06-23
申请人： Edward M. Gillis , Felix Theeuwes
发明人： Edward M. Gillis , Felix Theeuwes
IPC分类号： A61M2500
CPC分类号： A61M25/0026 , A61M25/0032 , A61M2025/0036 , A61M2025/0056 , A61M2025/0063
摘要： The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and implantation of the composite catheter, while the inner diameter of the inner member has the size and other characteristics suitable for delivery of a drug through a lumen of the inner member. The interstitial space imparts flexibility to the composite catheter by, for example, removing material from the cross-sectional area that would otherwise provide additional stiffness to the catheter, and/or by accommodating movement of the outer member relative to the inner member.
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公开(公告)号：US06183466B2
公开(公告)日：2001-02-06
申请号：US09344811
申请日：1999-06-25
IPC分类号： A61K948
CPC分类号： A61K9/4808 , A61K9/0004
摘要： A dosage form is disclosed comprising a wall that defines an injection-molded compartment housing a capsule comprising a drug formulation.
摘要翻译： 公开了一种剂型，其包含壁，其限定容纳包含药物制剂的胶囊的注射模制隔室。
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