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182 条记录 (耗时 0.037 秒)

    Drug releasing coatings for medical devices
    71.
    发明授权
    Drug releasing coatings for medical devices 有权
    用于医疗器械的药物释放涂层

    公开(公告)号：US08414525B2

    公开(公告)日：2013-04-09

    申请号：US12121986

    申请日：2008-05-16

    申请人： Lixiao Wang

    发明人： Lixiao Wang

    IPC分类号： A61M25/10 ,  A61K31/337 ,  A61K31/436

    CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/80 ,  A61L2300/802 ,  A61K2300/00

    摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

    摘要翻译： 本发明涉及一种用于将治疗剂递送至组织的医疗装置。 医疗装置具有覆盖医疗装置的外表面的层。 该层含有治疗剂和添加剂。 在某些实施方案中，添加剂具有亲水部分和药物亲和部分，其中药物亲和部分是疏水部分，通过氢键与治疗剂具有亲和性的部分中的至少一个，以及具有 通过范德华相互作用对治疗剂的亲和力。 在实施方案中，添加剂是水溶性的。 在另外的实施方案中，添加剂是表面活性剂和化合物中的至少一种，化合物的分子量为80至750或具有多于4个羟基。

    Drug releasing coatings for medical devices
    72.
    发明授权
    Drug releasing coatings for medical devices 有权

    公开(公告)号：US08366662B2

    公开(公告)日：2013-02-05

    申请号：US13042221

    申请日：2011-03-07

    申请人： Lixiao Wang

    发明人： Lixiao Wang

    IPC分类号： A61L29/16 ,  A61M25/10

    CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/80 ,  A61L2300/802 ,  A61K2300/00

    摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

    CATHETER HAVING AN IMPROVED BALLOON-TO-CATHETER BOND
    73.
    发明申请
    CATHETER HAVING AN IMPROVED BALLOON-TO-CATHETER BOND 有权
    具有改进的气球到导管束的导管

    公开(公告)号：US20110172599A1

    公开(公告)日：2011-07-14

    申请号：US13073334

    申请日：2011-03-28

    申请人： John Chen ,  Nie Tang ,  Ed Parsonage ,  Paul Miller ,  Lixiao Wang

    发明人： John Chen ,  Nie Tang ,  Ed Parsonage ,  Paul Miller ,  Lixiao Wang

    IPC分类号： A61M25/10 ,  B32B37/02 ,  B32B37/12 ,  B32B37/14

    CPC分类号： A61M25/0014

    摘要： A balloon catheter assembly includes a first tubular member with a proximal portion and a distal portion and a lumen extending between the proximal portion and the distal portion. A balloon has a proximal waist length, a distal waist length and an expandable region therebetween disposed about the distal portion. A tie layer is disposed between the proximal waist length or distal waist length and the first tubular member. The tie layer comprises a polyester polymer and a polyamide polymer.

    摘要翻译： 球囊导管组件包括具有近端部分和远端部分的第一管状部件和在近端部分和远端部分之间延伸的内腔。 气球具有近端腰部长度，远端腰围长度和围绕远侧部分设置的可扩张区域。 连接层设置在近端腰部长度或远端腰部长度与第一管状部件之间。 连结层包含聚酯聚合物和聚酰胺聚合物。

    Embolic protection systems for bifurcated conduits
    76.
    发明申请
    Embolic protection systems for bifurcated conduits 有权
    用于分叉管道的栓塞保护系统

    公开(公告)号：US20070150044A1

    公开(公告)日：2007-06-28

    申请号：US11645142

    申请日：2006-12-22

    申请人： Lixiao Wang ,  Martin Chambers

    发明人： Lixiao Wang ,  Martin Chambers

    IPC分类号： A61F2/06

    CPC分类号： A61M25/104 ,  A61B17/1204 ,  A61F2/958 ,  A61F2/966

    摘要： An apparatus for removing emboli from a vessel during an interventional procedure comprising a catheter. The catheter includes: an elongate member having a lumen extending from the proximal end to the distal end; a dilation element disposed on a distal portion of the elongate member, the dilation element having a contracted state and an expanded state; an occlusion element disposed on a distal portion of the elongate member, the occlusion element being disposed proximal of the dilation element, and the occlusion element having a contracted state and an expanded state; and one or more aspiration ports disposed on a distal portion of the elongate member, the one or more aspiration ports being in fluid communication with the lumen, and one or more of the aspiration ports being disposed proximal of the dilation element and distal of the occlusion element.

    摘要翻译： 一种用于在包括导管的介入手术过程中从血管中去除栓塞的装置。 导管包括：细长构件，其具有从近端延伸到远端的内腔; 设置在细长构件的远端部分上的扩张元件，膨胀元件具有收缩状态和膨胀状态; 设置在所述细长构件的远侧部分上的遮挡元件，所述遮挡元件设置在所述扩张元件的近侧，所述遮挡元件具有收缩状态和膨胀状态; 以及设置在所述细长构件的远侧部分上的一个或多个抽吸口，所述一个或多个抽吸端口与所述内腔流体连通，并且一个或多个吸入口设置在所述扩张元件的近侧和所述闭塞的远侧 元件。

    Catheter having an improved balloon-to-catheter bond
    79.
    发明授权
    Catheter having an improved balloon-to-catheter bond 有权
    导管具有改善的气球与导管接合

    公开(公告)号：US06923787B2

    公开(公告)日：2005-08-02

    申请号：US10027417

    申请日：2001-12-20

    申请人： Lixiao Wang

    发明人： Lixiao Wang

    IPC分类号： A61L29/00 ,  A61F2/958 ,  A61M25/00 ,  A61M29/00 ,  A61B1/267 ,  A61B6/00 ,  A61M31/00

    CPC分类号： A61M25/0014

    摘要： A tie layer insert is disclosed to aid in bond formation between an expandable balloon and a distal portion of a catheter shaft. The tie layer insert can be a single layer applied directly to the structural surfaces, or alternatively, the tie layer may be incorporated into a preformed polymeric insert. In the latter embodiment, the polymeric insert may include several layers of polymeric material. During the manufacturing process, the preformed polymeric insert is positioned between the distal portion of the expandable balloon and the catheter shaft. The entire distal region is then processed to form a sealably bonded expandable balloon to the distal end of the catheter shaft.

    摘要翻译： 公开了一种连接层插入件，以帮助可扩张气囊和导管轴的远端部分之间的结合。 连接层插入件可以是直接施加到结构表面的单层，或者可以将粘结层结合到预成型的聚合物插入物中。 在后一实施例中，聚合物插入物可以包括几层聚合材料。 在制造过程中，预成型的聚合物插入件位于可膨胀气囊的远端部分和导管轴之间。 然后整个远端区域被处理以形成可密封地结合的可扩张气囊到导管轴的远端。