公开(公告)号：US20240342340A1

公开(公告)日：2024-10-17

申请号：US18269639

申请日：2021-12-27

申请人： MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： Shoji FURUSAKO ,  Naoto TSUDA

IPC分类号： A61L27/34 ,  A61L15/28 ,  A61L27/26 ,  A61L27/54

CPC分类号： A61L27/34 ,  A61L15/28 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/64

摘要： There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.

公开(公告)号：US20240299149A1

公开(公告)日：2024-09-12

申请号：US17951483

申请日：2022-09-23

申请人： Cell and Molecular Tissue Engineering, LLC

发明人： Ulrike W. Klueh ,  Donald L. Kreutzer

IPC分类号： A61F2/00 ,  A61L31/10 ,  A61L31/16 ,  A61M5/158

CPC分类号： A61F2/0063 ,  A61L31/10 ,  A61L31/16 ,  A61M5/158 ,  A61B5/14532 ,  A61B5/686 ,  A61B2562/18 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L2300/414 ,  A61L2300/64 ,  A61M2005/1581 ,  A61M2205/0205

摘要： Disclosed herein are medical products, including an implantable device coated with an extracellular matrix comprising Type IV collagen and laminin, wherein the implantable device comprises at least one member selected from the group consisting of sensors, meshes and cannulas, and the extracellular matrix contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less. Corresponding systems and method also are disclosed.

公开(公告)号：US20240181134A1

公开(公告)日：2024-06-06

申请号：US18345212

申请日：2023-06-30

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Arvydas Usas ,  Karin Payne ,  Thomas Payne ,  Ronald Jankowski ,  Johnny Huard

IPC分类号： A61L27/38 ,  A61K35/12 ,  A61K35/38 ,  A61L27/36 ,  A61L27/54 ,  A61L27/58 ,  C12N5/077 ,  C12N11/02

CPC分类号： A61L27/3895 ,  A61K35/38 ,  A61L27/3629 ,  A61L27/365 ,  A61L27/3826 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/58 ,  C12N5/0652 ,  C12N5/0658 ,  C12N5/0659 ,  C12N11/02 ,  A61K35/12 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/40 ,  C12N2533/92

摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

公开(公告)号：US11998660B2

公开(公告)日：2024-06-04

申请号：US16795770

申请日：2020-02-20

申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN

发明人： Daniel John Kelly ,  Grainne Cunniffe ,  Henrique Almeida ,  Rajalakshmanan Eswaramoorthy ,  Conor Buckley ,  Pedro Jose Diaz Payno ,  David Browe

IPC分类号： A61L27/50 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

CPC分类号： A61L27/3633 ,  A61L27/3612 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/40

摘要： A method for making a porous devitalised scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal comprises the steps of providing micronized extracellular matrix (ECM) tissue, mixing the micronized extracellular matrix with a liquid to provide a slurry, and freeze-drying the slurry to provide the porous scaffold. A porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal and comprising a porous freeze-dried matrix formed from micronised decellularised extracellular matrix tissue is also described.

公开(公告)号：US20240165046A1

公开(公告)日：2024-05-23

申请号：US18282545

申请日：2022-01-28

申请人： Aalto University Foundation sr

发明人： Jani Kuula ,  Eija Raussi-Lehto ,  Orlando Rojas ,  Rubina Ajdary ,  Tomi Mikkola

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/717 ,  A61L27/20 ,  A61L27/54

CPC分类号： A61K9/70 ,  A61K9/0024 ,  A61K31/717 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/22 ,  A61L2430/34

摘要： According to an example aspect of the present invention, there is provided a composition for use in the treatment of urinary or faecal incontinence, the composition comprising a nanostructured cellulosic material.

公开(公告)号：US20240091410A1

公开(公告)日：2024-03-21

申请号：US18038234

申请日：2021-11-24

申请人： OAK CREST INSTITUTE OF SCIENCE

发明人： Marc M. Baum ,  Peter A. Anton ,  Manjula Gunawardana ,  John A. Moss

IPC分类号： A61L27/36 ,  A61L27/16 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/3679 ,  A61L27/16 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/64

摘要： Provided herein are drug delivery devices, comprising a scaffold comprising one or more biocompatible materials, one or more chambers containing a plurality of cells, one or more membranes, and one or more nutrient supplementation systems. Also provided are methods of treating or preventing diseases and disorders in a subject in need thereof, comprising administering to the subject the drug delivery devices disclosed herein, and methods of making the drug delivery devices disclosed herein.

公开(公告)号：US20240001005A1

公开(公告)日：2024-01-04

申请号：US18250049

申请日：2021-10-21

申请人： REAPPLIX A/S

发明人： Rasmus LUNDQUIST ,  Niels Erik HOLM ,  Morten Rosenberg ESKILDSEN

IPC分类号： A61L31/04 ,  A61L31/16

CPC分类号： A61L31/046 ,  A61L31/16 ,  A61L2300/64

摘要： A method for preventing surgical adhesion between surfaces that are to be prevented uses a blood product having fibrin. The blood product can be a singled layered blood product having components from plasma, components added to initiate a coagulation process, and components created during the coagulation process. The products and methods can be used for preventing surgical adhesion, for stopping or reducing bleeding in an open surgical wound, and for treating surgical wounds.

公开(公告)号：US20230381375A1

公开(公告)日：2023-11-30

申请号：US18034564

申请日：2021-10-29

申请人： CellFiber Co., Ltd. ,  SAPPORO MEDICAL UNIVERSITY

发明人： Kanna NAGAISHI ,  Kazuhiro IKEDA

IPC分类号： A61L27/38 ,  A61L27/20 ,  A61L27/24 ,  C12N5/00 ,  A61L27/36 ,  A61L27/52 ,  A61P1/04

CPC分类号： A61L27/3834 ,  A61L27/20 ,  A61L27/24 ,  C12N5/0012 ,  A61L27/3641 ,  A61L27/52 ,  A61P1/04 ,  A61L2300/64

摘要： Provided is a novel structure containing mesenchymal stem cells that can be used in various applications. A hydrogel fiber (10) comprises a hydrogel (14) that contains mesenchymal stem cells.

公开(公告)号：US11766823B2

公开(公告)日：2023-09-26

申请号：US17233626

申请日：2021-04-19

申请人： University of Florida Research Foundation, Inc. ,  Georgia Tech Research Corporation

发明人： Thomas Ettor Angelini ,  Wallace Gregory Sawyer ,  Kyle Gene Rowe ,  Tapomoy Bhattacharjee ,  Alberto Fernandez-Nieves ,  Ya-Wen Chang ,  Samantha M. Marquez

IPC分类号： B29C64/118 ,  C12N5/00 ,  B33Y80/00 ,  B33Y70/00 ,  A61F2/30 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/36 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/60 ,  C12N5/071 ,  A61K35/00 ,  B29L31/00

CPC分类号： B29C64/118 ,  A61F2/30942 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L27/60 ,  B33Y70/00 ,  B33Y80/00 ,  C12N5/0062 ,  C12N5/069 ,  C12N5/0686 ,  A61F2002/30962 ,  A61F2240/002 ,  A61K35/00 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/20 ,  A61L2430/26 ,  B29L2031/7532 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/74 ,  C12N2533/80

摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

公开(公告)号：US11678967B2

公开(公告)日：2023-06-20

申请号：US16489601

申请日：2018-02-28

申请人： University College Cork—National University of Ireland, Cork

发明人： Noel Caplice

IPC分类号： A61F2/06 ,  A61L27/54 ,  A61F2/02 ,  A61L27/44 ,  A61L27/50 ,  A61L27/58 ,  A61F2/848

CPC分类号： A61F2/022 ,  A61F2/06 ,  A61L27/44 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/8486 ,  A61F2210/0004 ,  A61F2230/0023 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2250/0067 ,  A61L2300/64

摘要： An intravascular cell therapy device comprises a scaffold (2, 12) that is radially adjustable between a contracted orientation suitable for transluminal delivery to a vascular locus and an expanded orientation, and a biodegradable matrix provided on at least a portion of the scaffold that is suitable for seeding with cells and degrades in a vascular environment. The scaffold is configured to have a distal piercing tip (5) when in a deployed orientation. The scaffold comprises a plurality of sidewall panels (3, 13, 14) arranged around a longitudinal axis of the scaffold, and adjustable couplings (4) between the panels configured for adjustment between an expanded configuration and a contracted orientation, and in which each sidewall panel comprises a matrix suitable for seeding with cells.