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    Polymorphs of suberoylanilide hydroxamic acid
    71.
    发明申请
    Polymorphs of suberoylanilide hydroxamic acid 有权
    辛二酰苯胺异羟肟酸的多晶型物

    公开(公告)号：US20080228005A1

    公开(公告)日：2008-09-18

    申请号：US12077415

    申请日：2008-03-18

    申请人： Thomas A. Miller

    发明人： Thomas A. Miller

    IPC分类号： C07C233/01

    CPC分类号： A61K31/19 ,  A61K9/0019 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/13 ,  A61K31/165 ,  A61K31/44 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13 ,  C07C259/06

    摘要： The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.

    摘要翻译： 本发明提供了通过施用包含有效的HDAC抑制剂的药物组合物选择性诱导肿瘤细胞的终末分化，细胞生长停滞和/或细胞凋亡和/或抑制组蛋白脱乙酰酶（HDAC）的方法。 本发明的药物组合物中活性化合物的口服生物利用度令人惊奇的高。 此外，药物组合物在长时间内意外地引起活性化合物的高，治疗有效的血液水平。 本发明进一步提供这些药物组合物的安全的每日给药方案，其易于遵循，并且其在体内导致治疗有效量的HDAC抑制剂。 本发明还提供了SAHA的新型I型多晶型物，其特征在于独特的X射线衍射图和差示扫描量热法谱，以及独特的晶体结构。

    Methods of treating cancer with HDAC inhibitors
    72.
    发明申请
    Methods of treating cancer with HDAC inhibitors 审中-公开
    用HDAC抑制剂治疗癌症的方法

    公开(公告)号：US20080227862A1

    公开(公告)日：2008-09-18

    申请号：US11980994

    申请日：2007-10-30

    申请人： Victoria M. Richon ,  Judy H. Chiao ,  Thomas A. Miller ,  Nicholas G. Bacopoulos ,  Carolyn M. Paradise

    发明人： Victoria M. Richon ,  Judy H. Chiao ,  Thomas A. Miller ,  Nicholas G. Bacopoulos ,  Carolyn M. Paradise

    IPC分类号： A61K31/167 ,  A61P19/00

    CPC分类号： A61K31/19 ,  A61K31/44 ,  A61K38/12

    摘要： The present invention relates to methods of treating cancers, e.g., leukemia. More specifically, the present invention relates to methods of treating acute and chronic leukemias including Acute Lymphocytic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic leukemia (CLL), Chronic myeloid leukemia (CML) and Hairy Cell Leukemia, by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.

    摘要翻译： 本发明涉及治疗癌症例如白血病的方法。 更具体地说，本发明涉及治疗急性和慢性白血病的方法，包括急性淋巴细胞白血病（ALL），急性骨髓性白血病（AML），慢性淋巴细胞白血病（CLL），慢性骨髓性白血病（CML）和毛细胞白血病 包含HDAC抑制剂的药物组合物，例如辛二酰苯胺异羟肟酸（SAHA）。 药物组合物的口服制剂具有有利的药代动力学特征，例如高生物利用度，并且令人惊讶地在长时间内引起活性化合物的高血药浓度。 本发明进一步提供这些药物组合物的安全的每日给药方案，其易于遵循，并且其在体内导致治疗有效量的HDAC抑制剂。

    Polymorphs of suberoylanilide hydroxamic acid
    73.
    发明申请
    Polymorphs of suberoylanilide hydroxamic acid 有权

    公开(公告)号：US20080194692A1

    公开(公告)日：2008-08-14

    申请号：US11981367

    申请日：2007-10-30

    申请人： Thomas A. Miller ,  Victoria M. Richon

    发明人： Thomas A. Miller ,  Victoria M. Richon

    IPC分类号： A61K31/16 ,  A61P35/00

    CPC分类号： A61K31/19 ,  A61K9/0019 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/13 ,  A61K31/165 ,  A61K31/44 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13 ,  C07C259/06

    摘要： The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.

    Methods of Inducing Terminal Differentiation
    74.
    发明申请
    Methods of Inducing Terminal Differentiation 有权
    诱导终点分化的方法

    公开(公告)号：US20080119562A1

    公开(公告)日：2008-05-22

    申请号：US11853700

    申请日：2007-09-11

    申请人： Victoria M. Richon ,  Judy H. Chiao ,  William Kevin Kelly ,  Thomas A. Miller

    发明人： Victoria M. Richon ,  Judy H. Chiao ,  William Kevin Kelly ,  Thomas A. Miller

    IPC分类号： A61K31/164 ,  A61P35/00

    CPC分类号： A61K9/4866 ,  A61K9/0019 ,  A61K9/1652 ,  A61K31/13 ,  A61K31/164 ,  A61K31/165 ,  A61K31/19 ,  A61K31/44 ,  A61K38/12 ,  A61K47/12 ,  A61K47/38

    摘要： The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.

    摘要翻译： 本发明提供了通过施用包含有效的HDAC抑制剂的药物组合物选择性诱导肿瘤细胞的终末分化，细胞生长停滞和/或细胞凋亡和/或抑制组蛋白脱乙酰酶（HDAC）的方法。 本发明的药物组合物中活性化合物的口服生物利用度令人惊奇的高。 此外，药物组合物在长时间内意外地引起活性化合物的高，治疗有效的血液水平。 本发明进一步提供这些药物组合物的安全的每日给药方案，其易于遵循，并且其在体内导致治疗有效量的HDAC抑制剂。

    Storage tray with charging
    78.
    发明授权
    Storage tray with charging 有权
    储物盘带充电

    公开(公告)号：US08981714B2

    公开(公告)日：2015-03-17

    申请号：US13234065

    申请日：2011-09-15

    申请人： Thomas A. Miller ,  Roy Thorsell

    发明人： Thomas A. Miller ,  Roy Thorsell

    IPC分类号： H02J7/00 ,  H02J7/02

    CPC分类号： H02J50/10 ,  H02J7/025 ,  H02J50/40 ,  Y02T90/122 ,  Y10T29/49117

    摘要： A wireless charging system includes a charging pad including a base having a coil. The charging pad includes an electrical connector connected to the coil for supplying power to the coil. The charging pad can be connected by an AC cord to a household AC outlet via the electrical connector. The charging pad can also be connected to a vehicle connector for connecting the charging pad to a vehicle electrical supply. In this manner, the wireless charging pad can be used for both home and vehicle charging.

    摘要翻译： 无线充电系统包括具有线圈的基座的充电垫。 充电垫包括连接到线圈的电连接器，用于向线圈供电。 充电垫可以通过交流电线通过电气连接器连接到家用交流电源插座。 充电垫还可以连接到用于将充电垫连接到车辆电源的车辆连接器。 以这种方式，无线充电垫可以用于家庭和车辆充电。

    Recharging or connection tray for portable electronic devices
    79.
    发明授权
    Recharging or connection tray for portable electronic devices 失效
    便携式电子设备的充电或连接托盘

    公开(公告)号：US08624547B2

    公开(公告)日：2014-01-07

    申请号：US12970205

    申请日：2010-12-16

    申请人： Roy Thorsell ,  Thomas A. Miller

    发明人： Roy Thorsell ,  Thomas A. Miller

    IPC分类号： H02J7/00

    CPC分类号： H02J7/0044 ,  B60N3/002 ,  B60N2002/0264 ,  B60R11/02 ,  B60R2011/0005 ,  B60R2011/0007 ,  B60R2011/0075 ,  B60R2011/0094 ,  H02J7/0021 ,  H02J7/0027 ,  H02J7/025 ,  H02J50/10 ,  H02J50/40 ,  H02J50/90 ,  Y10T29/49826

    摘要： The present invention relates to a tray comprising: a) a base panel having two opposite edges adapted for sliding within grooves of a structure; b) a pair of electrical contacts located on the two opposite edges of the base adapted to conduct electricity; c) a battery recharging system adapted to provide one or more electromagnetic fields capable of transferring an electrical charge to a properly equipped electrical device having a rechargeable battery or a connection for a portable electronic device adapted to connect the portable electronic device to the power system of a host and/or other electronic systems of the host; d) means for connecting the pair of electrical contacts to the battery recharging system or to the connection to the portable electronic device; e) one or more display panels providing a surface for resting one or more rechargeable portable electric devices upon, such panels adapted to allow one or more users of portable electronic device to view one or more displays of the portable electronic devices; f) panels for connecting the base panel and one or more display panels and for enclosing the tray. The tray is adapted for use in a host system which supplies power to the tray. In a preferred embodiment, the host system is or is utilized in a vehicle.

    摘要翻译： 托盘技术领域本发明涉及一种托盘，该托盘包括：a）底板，其具有适于在结构的凹槽内滑动的两个相对的边缘; b）位于基座的两个相对边缘上的一对电触头，适于导电; c）电池充电系统，其适于提供一个或多个电磁场，其能够将电荷转移到具有可再充电电池的正确配备的电气装置或适于将便携式电子装置连接到电力系统的便携式电子装置的连接 主机和/或主机的其他电子系统; d）用于将一对电触点连接到电池充电系统或者连接到便携式电子设备的装置; e）一个或多个显示面板，其提供用于将一个或多个可再充电便携式电气设备放置在其上的表面，所述面板适于允许便携式电子设备的一个或多个用户观看便携式电子设备的一个或多个显示器; f）用于连接基板和一个或多个显示面板并用于封闭托盘的面板。 托盘适用于向托盘供电的主机系统中。 在优选实施例中，主机系统是或者被用于车辆中。

    Electrical probe and associated method
    80.
    发明授权
    Electrical probe and associated method 有权
    电探头及相关方法

    公开(公告)号：US08310223B2

    公开(公告)日：2012-11-13

    申请号：US12859713

    申请日：2010-08-19

    申请人： Edward K. Hoffman ,  Thomas A. Miller

    发明人： Edward K. Hoffman ,  Thomas A. Miller

    IPC分类号： G01R31/02 ,  G01R31/20

    CPC分类号： G01R1/06788

    摘要： An electrical probe and associated method are provided to establish electrical contact with a wire. The electrical probe includes an elongate member extending between opposed first and second ends, and first and second needles connected to the elongate member and extending beyond the first end of the elongate member. The electrical probe also includes first and second conductors electrically connected to the first and second needles, respectively, and extending along the elongate member. The electrical probe also includes a bumper stop connected to the elongate member proximate the first end of the tube. Further, the electrical probe includes a movable engagement member extending lengthwise along the elongate member. The moveable engagement member includes a hook that extends beyond the first end of the elongate member and beyond the first and second needles. The hook may include a terminal portion configured to contact the bumper stop.

    摘要翻译： 提供电探针和相关方法以建立与电线的电接触。 电探针包括在相对的第一和第二端之间延伸的细长构件，以及连接到细长构件并延伸超出细长构件的第一端的第一和第二针。 电探针还包括分别电连接到第一针和第二针并且沿着细长构件延伸的第一和第二导体。 电探针还包括连接到靠近管的第一端的细长构件的保险杠止动件。 此外，电探针包括沿着细长构件纵向延伸的可移动接合构件。 可移动接合构件包括延伸超过细长构件的第一端并超出第一和第二针的钩。 钩可以包括构造成接触保险杠止动件的端子部分。