公开(公告)号：US20100105105A1

公开(公告)日：2010-04-29

申请号：US12605325

申请日：2009-10-24

申请人： Oscar Azucena ,  Joel Kubby ,  Jian Cao ,  William Sullivan

发明人： Oscar Azucena ,  Joel Kubby ,  Jian Cao ,  William Sullivan

IPC分类号： C12Q1/00

CPC分类号： G01N21/41 ,  G01N21/6456 ,  G01N2496/00 ,  G02B21/16 ,  G02B26/06

摘要： Methods of microscopic imaging of biological tissue using adaptive optics technology to improve the image focus and sharpness. Wavefront measurements are taken by using a novel method of seeding biological tissue by using a fluorescent microsphere as a “guide star” as a natural point-source reference. The current methods are capable of improving the Strehl ratio of modern biological microscopes as much as 15 times.

摘要翻译： 使用自适应光学技术对生物组织进行显微成像的方法，以提高图像焦点和锐度。 通过使用荧光微球作为自然点源参考的“引导星”，通过使用将生物组织接种的新颖方法进行波前测量。 目前的方法能够将现代生物显微镜的Strehl比提高15倍。

公开(公告)号：US07706869B2

公开(公告)日：2010-04-27

申请号：US10826618

申请日：2004-04-16

申请人： Jian Cao ,  Jeffrey M. Gillberg

发明人： Jian Cao ,  Jeffrey M. Gillberg

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B5/02405 ,  A61B5/0456 ,  A61N1/3702

摘要： A method and device for generating a template that includes identifying events of a plurality of sensed events having predetermined characteristics as first selected events and generating the template from the first selected events. Events of the plurality of events having the predetermined characteristics are identified as second selected events, and a determination is made as to whether the template is valid in response to the second selected events. The template is updated from the second selected events in response to the template not being valid.

摘要翻译： 一种用于生成模板的方法和装置，包括将具有预定特征的多个感测事件的事件识别为第一选定事件，并从第一选定事件生成模板。 具有预定特性的多个事件的事件被识别为第二选定事件，并且确定该模板是否响应于第二选定事件而有效。 响应于模板无效，从第二个选定的事件更新模板。

公开(公告)号：US20090093860A1

公开(公告)日：2009-04-09

申请号：US11866700

申请日：2007-10-03

申请人： Paul A. Belk ,  Jeffrey M. Gillberg ,  Jian Cao ,  Charles D. Swerdlow

发明人： Paul A. Belk ,  Jeffrey M. Gillberg ,  Jian Cao ,  Charles D. Swerdlow

IPC分类号： A61N1/365

CPC分类号： A61N1/3987 ,  A61N1/385 ,  A61N1/3943 ,  A61N1/3962

摘要： A method and apparatus for determining a T-wave shock interval sense a cardiac electrogram (EGM) signal comprising a T-wave signal. A T-wave center is determined from the EGM signal, and a T-wave shock interval is determined in response to determining the T-wave center. A T-wave shock is delivered at the T-wave shock interval computed based on the T-wave center.

摘要翻译： 一种用于确定T波冲击间隔的方法和装置，其感测包括T波信号的心电图（EGM）信号。 从EGM信号确定T波中心，并且响应于确定T波中心来确定T波冲击间隔。 在基于T波中心计算出的T波冲击时间间隔内传递T波冲击。

公开(公告)号：US07333855B2

公开(公告)日：2008-02-19

申请号：US11107706

申请日：2005-04-15

申请人： Bruce D. Gunderson ,  Jian Cao ,  Troy E. Jackson

发明人： Bruce D. Gunderson ,  Jian Cao ,  Troy E. Jackson

IPC分类号： A61N1/08

CPC分类号： A61N1/3704 ,  A61N1/3925

摘要： A method and apparatus for determining oversensing in a medical device that includes sensing cardiac signals and detecting cardiac events via a first electrode configuration, determining the presence of an episode event in response to the detected cardiac events, and sensing the cardiac signals via a second electrode configuration. Amplitudes associated with a predetermined number of cardiac signals sensed via the second electrode configuration corresponding to the event episode are determined, and delivery of therapy is controlled in response to the determined amplitudes.

摘要翻译： 一种用于确定医疗设备中的过度感测的方法和装置，其包括经由第一电极配置感测心脏信号和检测心脏事件，响应于检测到的心脏事件确定发作事件的存在，以及经由第二电极感测心脏信号 组态。 确定与通过对应于事件发作的第二电极配置感测的预定数量的心脏信号相关联的幅度，并且响应于所确定的幅度来控制治疗的递送。

公开(公告)号：US07062315B2

公开(公告)日：2006-06-13

申请号：US10132773

申请日：2002-04-25

申请人： Lev A. Koyrakh ,  Eugene Davydov ,  Jeffrey M. Gillberg ,  Jian Cao

发明人： Lev A. Koyrakh ,  Eugene Davydov ,  Jeffrey M. Gillberg ,  Jian Cao

IPC分类号： A61B5/04

CPC分类号： A61B5/04525 ,  A61B5/0464 ,  A61N1/3622 ,  A61N1/3962

摘要： A method of generating a template in an implantable medical device for implantation within a patient, and a processor readable medium for performing the method, that includes generating a template from collected events corresponding to the patient, delaying the generation of the template for a first predetermined time period in response to the template not being generated within a predetermined number of collected events, determining whether the template is valid, and monitoring the template to determine whether the template is an accurate representation of the patient.

公开(公告)号：US20060116732A1

公开(公告)日：2006-06-01

申请号：US11107706

申请日：2005-04-15

申请人： Bruce Gunderson ,  Jian Cao ,  Troy Jackson

发明人： Bruce Gunderson ,  Jian Cao ,  Troy Jackson

IPC分类号： A61N1/37

CPC分类号： A61N1/3704 ,  A61N1/3925

摘要： A method and apparatus for determining oversensing in a medical device that includes sensing cardiac signals and detecting cardiac events via a first electrode configuration, determining the presence of an episode event in response to the detected cardiac events, and sensing the cardiac signals via a second electrode configuration. Amplitudes associated with a predetermined number of cardiac signals sensed via the second electrode configuration corresponding to the event episode are determined, and delivery of therapy is controlled in response to the determined amplitudes.

摘要翻译： 一种用于确定医疗设备中的过度感测的方法和装置，其包括经由第一电极配置感测心脏信号和检测心脏事件，响应于检测到的心脏事件确定发作事件的存在，以及经由第二电极感测心脏信号 组态。 确定与通过对应于事件发作的第二电极配置感测的预定数量的心脏信号相关联的幅度，并且响应于所确定的幅度来控制治疗的递送。

公开(公告)号：US20050234358A1

公开(公告)日：2005-10-20

申请号：US10826512

申请日：2004-04-16

申请人： Jian Cao ,  Jeffrey Gillberg

发明人： Jian Cao ,  Jeffrey Gillberg

IPC分类号： A61B5/0402 ,  A61B5/0452 ,  A61B5/0464 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/3622 ,  G16H40/63

摘要： A method and device for generating a template that includes determining whether there are consecutive events of a plurality of sensed events having first characteristics, and if a predetermined number of events of the plurality of sensed events subsequent to the consecutive events are identified as first selected events having second characteristics, the template is then generated from the first selected events.

摘要翻译： 一种用于生成模板的方法和装置，包括确定是否存在具有第一特征的多个感测事件的连续事件，以及如果连续事件之后的多个感测到的事件的预定数量的事件被识别为第一选定事件 具有第二特征，然后从第一选定事件生成模板。