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    METHOD AND APPARATUS FOR GENERATING A TEMPLATE FOR ARRHYTHMIA DETECTION AND ELECTROGRAM MORPHOLOGY CLASSIFICATION
    1.
    发明申请
    METHOD AND APPARATUS FOR GENERATING A TEMPLATE FOR ARRHYTHMIA DETECTION AND ELECTROGRAM MORPHOLOGY CLASSIFICATION 有权
    用于产生ARRHYTHMIA检测和电子形态学分类的模板的方法和装置

    公开(公告)号：US20070276276A1

    公开(公告)日：2007-11-29

    申请号：US11757495

    申请日：2007-06-04

    申请人： Jian Cao ,  Jeffrey Gillberg ,  Chris Gennaro

    发明人： Jian Cao ,  Jeffrey Gillberg ,  Chris Gennaro

    IPC分类号： A61B5/0452

    CPC分类号： A61B5/7264 ,  A61B5/04525 ,  A61B5/0464 ,  A61B5/726 ,  A61N1/3622 ,  A61N1/3956

    摘要： An implantable medical device and associated method for automatically generating morphology templates during fast cardiac rhythms, confirming a provisional template as a confirmed template, and using the confirmed template to classify subsequent detected arrhythmias. A provisional SVT template may be created during a fast ventricular rate and activated as a confirmed SVT template upon verification that the fast rate was due to an SVT. The confirmed SVT template may be used to discriminate SVT from VT/VF.

    摘要翻译： 一种用于在快速心脏节律期间自动生成形态学模板的可植入医疗装置和相关联的方法，确认临时模板作为确认的模板，并使用确认的模板来分类随后检测的心律失常。 可以在快速心室率期间创建临时SVT模板，并且在验证快速率是由于SVT引起的情况下被激活为确认的SVT模板。 可以使用确认的SVT模板来区分SVT与VT / VF。

    Automated Template Generation Algorithm for Implantable Device
    2.
    发明申请
    Automated Template Generation Algorithm for Implantable Device 有权
    可植入装置的自动模板生成算法

    公开(公告)号：US20060270937A1

    公开(公告)日：2006-11-30

    申请号：US11420521

    申请日：2006-05-26

    申请人： Lev Koyrakh ,  Eugene Davydov ,  Jeffrey Gillberg ,  Jian Cao

    发明人： Lev Koyrakh ,  Eugene Davydov ,  Jeffrey Gillberg ,  Jian Cao

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04525

    摘要： A method of generating a template in an implantable medical device for implantation within a patient, and a processor readable medium for performing the method, that includes generating a template from collected events corresponding to the patient, delaying the generation of the template for a first predetermined time period in response to the template not being generated within a predetermined number of collected events, determining whether the template is valid, and monitoring the template to determine whether the template is an accurate representation of the patient.

    摘要翻译： 一种在用于植入患者体内的可植入医疗装置中生成模板的方法，以及用于执行该方法的处理器可读介质，其包括从与患者相对应的收集的事件生成模板，延迟模板的生成，用于第一预定 响应于在预定数量的收集事件中不生成模板的时间段，确定模板是否有效，以及监视模板以确定模板是否是患者的准确表示。

    Automated template generation algorithm for implantable device
    3.
    发明申请
    Automated template generation algorithm for implantable device 有权
    用于植入式装置的自动模板生成算法

    公开(公告)号：US20050234358A1

    公开(公告)日：2005-10-20

    申请号：US10826512

    申请日：2004-04-16

    申请人： Jian Cao ,  Jeffrey Gillberg

    发明人： Jian Cao ,  Jeffrey Gillberg

    IPC分类号： A61B5/0402 ,  A61B5/0452 ,  A61B5/0464 ,  A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3956 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/3622 ,  G16H40/63

    摘要： A method and device for generating a template that includes determining whether there are consecutive events of a plurality of sensed events having first characteristics, and if a predetermined number of events of the plurality of sensed events subsequent to the consecutive events are identified as first selected events having second characteristics, the template is then generated from the first selected events.

    摘要翻译： 一种用于生成模板的方法和装置，包括确定是否存在具有第一特征的多个感测事件的连续事件，以及如果连续事件之后的多个感测到的事件的预定数量的事件被识别为第一选定事件 具有第二特征，然后从第一选定事件生成模板。

    Apparatus and method for testing an implantable medical device and sensing parameter settings
    4.
    发明申请
    Apparatus and method for testing an implantable medical device and sensing parameter settings 有权
    用于测试可植入医疗设备和感测参数设置的装置和方法

    公开(公告)号：US20070049982A1

    公开(公告)日：2007-03-01

    申请号：US11217050

    申请日：2005-08-31

    申请人： Jian Cao ,  Jeffrey Gillberg

    发明人： Jian Cao ,  Jeffrey Gillberg

    IPC分类号： A61N1/37

    CPC分类号： A61N1/37247 ,  A61N1/371

    摘要： In an apparatus and a method for use in setting a sensing parameter of an implantable medical device (IMD) of a patient, cardiac data corresponding to a cardiac episode experienced by the patient is obtained from a sensing electrode associated with the IMD. At the time the cardiac data is obtained, the IMD is operated at a first setting of the sensing parameter. Based upon this cardiac data, a simulation is performed of cardiac event identification if the IMD were operated at a different setting of the sensing parameter. The simulated cardiac event identification performance of the IMD is then reported.

    摘要翻译： 在用于设置患者的可植入医疗装置（IMD）的感测参数的装置和方法中，从与IMD相关联的感测电极获得与患者经历的心脏发作相对应的心脏数据。 在获得心脏数据时，在感测参数的第一设定下操作IMD。 基于该心脏数据，如果IMD在感测参数的不同设置下操作，则进行心脏事件识别的模拟。 然后报告IMD的模拟心脏事件识别性能。

    Automated template generation algorithm for implantable device
    5.
    发明申请
    Automated template generation algorithm for implantable device 有权
    用于植入式装置的自动模板生成算法

    公开(公告)号：US20050234359A1

    公开(公告)日：2005-10-20

    申请号：US10826618

    申请日：2004-04-16

    申请人： Jian Cao ,  Jeffrey Gillberg

    发明人： Jian Cao ,  Jeffrey Gillberg

    IPC分类号： A61B5/0456 ,  A61N1/362 ,  A61N1/37 ,  A61B5/04

    CPC分类号： A61N1/3622 ,  A61B5/02405 ,  A61B5/0456 ,  A61N1/3702

    摘要： A method and device for generating a template that includes identifying events of a plurality of sensed events having predetermined characteristics as first selected events and generating the template from the first selected events. Events of the plurality of events having the predetermined characteristics are identified as second selected events, and a determination is made as to whether the template is valid in response to the second selected events. The template is updated from the second selected events in response to the template not being valid.

    摘要翻译： 一种用于生成模板的方法和装置，包括将具有预定特征的多个感测事件的事件识别为第一选定事件，并从第一选定事件生成模板。 具有预定特性的多个事件的事件被识别为第二选定事件，并且确定该模板是否响应于第二选定事件而有效。 响应于模板无效，从第二个选定的事件更新模板。

    Safety and Efficacy with a CHO Cell Glycosylated Chimeric Antibody to TNF
    7.
    发明申请
    Safety and Efficacy with a CHO Cell Glycosylated Chimeric Antibody to TNF 审中-公开

    公开(公告)号：US20170247443A1

    公开(公告)日：2017-08-31

    申请号：US15403115

    申请日：2017-01-10

    申请人： Jian Cao ,  Jeffrey Su

    发明人： Jian Cao ,  Jeffrey Su

    IPC分类号： C07K16/24

    CPC分类号： C07K16/241 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515

    摘要： There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% NANA glycosylation terminal sialic acid and a glycosylation pattern of Gal-α(2,3/6)-Gal that binds to tumor necrosis factor alpha (TNF). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 2) as infliximab (Remicade®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1,3)-Gal.

    Electrical-assisted double side incremental forming and processes thereof
    9.
    发明授权
    Electrical-assisted double side incremental forming and processes thereof 有权
    电辅双面递增成型及其工艺

    公开(公告)号：US08741079B2

    公开(公告)日：2014-06-03

    申请号：US13221304

    申请日：2011-08-30

    申请人： John Roth ,  Jian Cao

    发明人： John Roth ,  Jian Cao

    IPC分类号： B21D26/00

    CPC分类号： C21D1/09 ,  B21D31/005 ,  B21D37/16 ,  B21J1/06 ,  C21D1/40 ,  C21D7/02 ,  C21D7/13 ,  C21D9/0018 ,  C21D9/0068 ,  C21D9/46 ,  C21D9/48 ,  C21D2261/00

    摘要： A process for forming a sheet metal component using an electric current passing through the component is provided. The process can include providing a double side incremental forming machine, the machine operable to perform a plurality of double side incremental deformations on the sheet metal component and also apply an electric direct current to the sheet metal component during at least part of the forming. The direct current can be applied before or after the forming has started and/or be terminated before or after the forming has stopped. The direct current can be applied to any portion of the sheet metal. The electrical assistance can reduce the magnitude of force required to produce a given amount of deformation, increase the amount of deformation exhibited before failure and/or reduce any springback typically exhibited by the sheet metal component.

    摘要翻译： 提供了使用通过该部件的电流来形成钣金元件的工艺。 该方法可以包括提供双面增量成型机，该机器可操作以在金属片部件上执行多个双面增量变形，并且还在成形的至少一部分期间向金属片部件施加电直流电。 可以在成形开始之前或之后施加直流电流和/或在成形停止之后终止直流电流。 直流电可以应用于金属片的任何部分。 电气辅助可以减少产生给定量的变形所需的力的大小，增加在故障之前显示的变形量和/或减少通常由金属片组件表现的任何回弹。