公开(公告)号：US20240302273A1

公开(公告)日：2024-09-12

申请号：US18180931

申请日：2023-03-09

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

发明人： Khurram Karim QURESHI ,  Md. Ahasan HABIB

IPC分类号： G01N21/41 ,  C03B37/027 ,  G02B6/02

CPC分类号： G01N21/41 ,  C03B37/0279 ,  G02B6/02328 ,  C03B2201/02 ,  C03B2203/42 ,  G01N2201/08

摘要： An optical sensor that includes a photonic crystal fiber (PCF) and an optical coupler. The PCF includes a hollow core with a first diameter (Dc), an inner cladding section, and an outer layer surrounding the inner cladding section. The inner cladding section includes a cladding material and a plurality of spaced apart circular-shaped channels disposed in the cladding material surrounding the hollow core. The cladding material includes at least one of glass, ceramic, and glass-ceramic. Each spaced apart circular-shaped channel has substantially the same size and an average diameter (d). A first end of the PCF is in optical communication with a light source and a second end of the PCF is in optical communication with the optical coupler.

公开(公告)号：US12036558B2

公开(公告)日：2024-07-16

申请号：US16963428

申请日：2018-10-24

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Koji Miyazaki ,  Hideyuki Fujii ,  Ko Osawa ,  Takanori Murayama

IPC分类号： G01N21/03 ,  B01L7/00 ,  G01N21/41 ,  G01N31/22

CPC分类号： B01L7/00 ,  G01N21/03 ,  G01N21/41 ,  G01N31/22

摘要： To provide a temperature adjustment stage that can efficiently heat a cartridge in accordance with necessity of heating each well. A temperature adjustment stage for heating a cartridge in which a plurality of wells that store a liquid are formed. The cartridge is used in an inspection system that detects an object captured by an immunoreaction, the wells include a labeled antibody well that stores a labeled antibody that labels the object, and there is provided a structure that does not heat the labeled antibody well.

公开(公告)号：US20240077415A1

公开(公告)日：2024-03-07

申请号：US18272421

申请日：2021-12-22

申请人： LS ELECTRIC CO., LTD.

发明人： Jae-Hun YOON

IPC分类号： G01N21/33 ,  G01N21/41

CPC分类号： G01N21/33 ,  G01N21/41 ,  G01N2021/1742

摘要： A transformer lifetime evaluation apparatus comprises a first storage part for storing insulation oil used for insulation of a transformer; a second storage part provided to be separated from the first storage part and storing insulation oil which is not used for the insulation of the transformer; a light-emitting unit for emitting light of a specified wavelength; a light-receiving unit for receiving light emitted from the light-emitting unit; a first optical cable connecting the light-emitting unit and the light-receiving unit, providing a moving path of light emitted from the light-emitting unit and received in the light-receiving unit; a second optical cable connecting the light-emitting unit and the light-receiving unit, providing a moving path of light emitted from the light-emitting unit and received in the light-receiving unit; and a calculation part connected to the light-receiving unit and receiving information about an optical property of methanol from the light-receiving unit.

公开(公告)号：US11823927B2

公开(公告)日：2023-11-21

申请号：US17229197

申请日：2021-04-13

申请人： Samsung Electronics Co., Ltd.

发明人： Kyunghun Han ,  Ingi Kim ,  Sangwoo Bae ,  Jungchul Lee ,  Minhwan Seo ,  Myeongock Ko ,  Youngjoo Lee ,  Taehyun Kim ,  Seulgi Lee

IPC分类号： G01J3/14 ,  H01L21/67 ,  G02B7/02 ,  G06T5/20 ,  G06T7/00 ,  G01N21/41 ,  G01N21/95 ,  G01N21/65

CPC分类号： H01L21/67288 ,  G01N21/41 ,  G01N21/65 ,  G01N21/9505 ,  G02B7/021 ,  G06T5/20 ,  G06T7/0004 ,  G01N2021/653 ,  G01N2201/06113 ,  G06T2207/30148

摘要： A wafer inspection apparatus includes: an objective lens on an optical path of first and second input beams; and an image sensor configured to generate an image of the wafer based on scattered light according to a nonlinear optical phenomenon based on the first and second input beams, wherein the first input beam passing through the objective lens is obliquely incident on the wafer at a first incident angle with respect to a vertical line that is normal to an upper surface of the wafer, the second input beam passing through the objective lens is incident on the wafer at a second incident angle oblique to the vertical line that is normal to the upper surface of the wafer, and the first and second incident angles are different from each other.

公开(公告)号：US11668608B2

公开(公告)日：2023-06-06

申请号：US17063816

申请日：2020-10-06

申请人： Tokyo Electron Limited

发明人： Tong Wu ,  Kenji Nagai

IPC分类号： G01J3/427 ,  G01K11/125 ,  G01N21/41 ,  G01K7/02 ,  G01N21/71

CPC分类号： G01K7/02 ,  G01J3/427 ,  G01K11/125 ,  G01N21/41 ,  G01N21/71 ,  G01N2201/1211

摘要： A temperature measurement system configured to measure a temperature of a target object having a first main surface and a second main surface includes a light source unit configured to emit output light penetrating the target object and including a first wavelength range and a second wavelength range; a measurement unit configured to measure a spectrum of reflected light; an optical path length ratio calculator configured to calculate an optical path length ratio between the output light of the first wavelength range and the output light of the second wavelength range; and a temperature calculator configured to calculate the temperature of the target object based on the optical path length ratio and a previously investigated relationship between the temperature of the target object and a refractive index ratio between the output light of the first wavelength range and the output light of the second wavelength range.

公开(公告)号：US11650149B2

公开(公告)日：2023-05-16

申请号：US17040647

申请日：2019-03-26

申请人： Georgia Tech Research Corporation

发明人： Francisco Robles ,  Patrick Ledwig

IPC分类号： G01N21/41 ,  G01N33/483 ,  G02B21/36 ,  G02B21/06 ,  G06K9/00 ,  G06V20/69

CPC分类号： G01N21/41 ,  G01N33/4833 ,  G02B21/06 ,  G02B21/365 ,  G06V20/693 ,  G06V20/698 ,  G01N2021/418 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/0826

摘要： Disclosed herein are systems and methods for imaging cells. Quantitative phase imaging uses variations in the index of refraction of a sample as a source of endogenous contrast, providing label-free information of sub-cellular structures and allowing for the reconstruction of valuable biophysical parameters, such as cell dry-mass at femtogram scales, mass transport, and sample thickness and fluctuations at nanometer scales. As a result, QPI has become a valuable tool in biology and medicine. However, QPI has suffered from the need for trans-illumination through relatively thin objects in order to gain access to the forward-scattered field, which carries crucial low spatial frequency information of a sample and avoid contributions from multiple scattered light or out-of-focus planes. The disclosed methods and systems can provide for reconstruction of QPI and corresponding analysis for imaging samples of cells in thick samples using an epi-illumination configuration.

公开(公告)号：US20190195872A1

公开(公告)日：2019-06-27

申请号：US16206294

申请日：2018-11-30

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Axel SCHERER ,  Samuel NJOROGE ,  Jingqing HUANG

IPC分类号： G01N33/566 ,  G01N33/543 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552

CPC分类号： G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

摘要： An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US20190154576A1

公开(公告)日：2019-05-23

申请号：US15571197

申请日：2016-05-03

申请人： BAE Systems Information and Electronic Systems Integration Inc.

发明人： Kevin R. Maschhoff ,  Gerard M. Perron ,  John J. Polizotti

IPC分类号： G01N21/41 ,  G01J3/18 ,  G01J3/28 ,  G01J5/00 ,  G01J5/20 ,  H01L31/107

CPC分类号： G01N21/41 ,  G01J3/18 ,  G01J3/2823 ,  G01J5/007 ,  G01J5/0205 ,  G01J5/041 ,  G01J5/061 ,  G01J5/20 ,  G01J2005/202 ,  G01N21/3518 ,  G01N21/3554 ,  G01N2021/1793 ,  G01N2021/3531 ,  G01W1/04 ,  H01L31/107

摘要： A mid-wave infrared system provides high spatial and temporal resolution measurements of atmospheric temperatures and moisture fields using a constellation of low earth orbit satellites. The disclosed system is smaller, lighter, less complex, and requires less energy than existing systems, due to implementation of an infrared avalanche photodiode array detector that provides enhanced sensitivity with reduced cooling requirements, and an Offner spectrometer having a novel a refractive element inserted near the grating that reduces the size and power requirements of the spectrometer. Embodiments of the disclosed method include deploying a constellation of devices for cooperative infrared sensing of atmospheric phenomena at similar rates, lower cost, and much higher resolution compared to geosynchronous approaches. Some embodiments further include combined analysis of measurements obtained by the disclosed devices with complementary measurements made by other low-earth and high-earth orbital and/or ground-based devices.

公开(公告)号：US20190033284A1

公开(公告)日：2019-01-31

申请号：US16046530

申请日：2018-07-26

申请人： HAMAMATSU PHOTONICS K.K.

发明人： Naoya MATSUMOTO ,  Koyo WATANABE ,  Hirotoshi TERADA

IPC分类号： G01N33/483 ,  G01N21/41 ,  G03H1/00 ,  G01N21/64 ,  G02B27/00 ,  G03H1/08 ,  G02B5/32 ,  G01B11/24 ,  G03H1/22 ,  G02B21/00 ,  G01N21/63

CPC分类号： G01N33/4833 ,  G01B11/24 ,  G01N21/41 ,  G01N21/636 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B5/32 ,  G02B21/00 ,  G02B21/16 ,  G02B27/0068 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0072

摘要： A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

公开(公告)号：US20180265908A1

公开(公告)日：2018-09-20

申请号：US15760348

申请日：2016-06-22

申请人： HAMAMATSU PHOTONICS K.K.

发明人： Tadashi FUKAMI ,  Hidenao YAMADA

IPC分类号： C12Q1/04 ,  G01N21/45 ,  G02B21/36

CPC分类号： C12Q1/04 ,  C12M41/38 ,  G01N15/1434 ,  G01N15/1468 ,  G01N21/41 ,  G01N21/45 ,  G01N33/5073 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2201/063 ,  G01N2400/00 ,  G02B21/00 ,  G02B21/361 ,  G02B21/365

摘要： The present invention relates to a cell determination method for determining a cell type based on a content of glycogen in a cell, including: an acquisition step of acquiring optical path length data by measuring an optical path length of the cell; a calculation step of calculating an optical path length indicator correlated with the optical path length of the cell from the obtained optical path length data; a comparison step of comparing the calculated optical path length indicator with a threshold; and a determination step of determining whether the cell is a cell type having a high glycogen content in the cell or a cell type having a low glycogen content in the cell, based on the comparison result.