Neuronal cell lineages and methods of production thereof
    72.
    发明申请
    Neuronal cell lineages and methods of production thereof 审中-公开
    神经元细胞谱系及其生产方法

    公开(公告)号:US20070053883A1

    公开(公告)日:2007-03-08

    申请号:US10550220

    申请日:2004-03-24

    摘要: Methods are provided in which a sterol-depleting agent such as β-cyclodextrin (βCD), is used to modulate signaling by a differentiation signaling protein such as Hedgehog protein or a BMP in vitro. As illustrated herein, the use of βCD in conjunction with Sonic Hedgehog N-terminal peptide (ShhN) causes substantially all of the cells in neural plate explants to differentiate as neurons, such as motor neurons. Also provided are cell therapy methods and screening methods that rely on the modulation of signaling of a differentiation signaling protein such as Hedgehog, by a sterol-depleting agent such as βCD.

    摘要翻译: 提供了其中使用甾体消耗剂如β-环糊精(βCD)来调节由分化信号蛋白如Hedgehog蛋白或BMP在体外的信号转导的方法。 如本文所示,βCD与Sonic Hedgehog N末端肽(ShhN)结合使用导致神经平板外植体中的所有细胞基本上分化为神经元,例如运动神经元。 还提供了依赖于诸如Hedgehog的分化信号蛋白的信号调节的细胞治疗方法和筛选方法,其通过消耗甾烷醇的消耗剂如βCD。

    System and method for selling on-line and off-line advertising in content delivered to a display screen
    75.
    发明申请
    System and method for selling on-line and off-line advertising in content delivered to a display screen 审中-公开
    用于在内容传送到显示屏幕上销售在线和离线广告的系统和方法

    公开(公告)号:US20060111970A1

    公开(公告)日:2006-05-25

    申请号:US10997520

    申请日:2004-11-24

    IPC分类号: G06Q30/00

    摘要: A method for selling on-screen advertising based on the relative page percentage an advertisement consumes on a paginated page displayed on a user's display. The invention includes a payment model for on-screen advertising based on “eyeball space” and placement. In one embodiment, paginated adaptable pages with advertising panes are authored and adaptable advertisements are created to fit the advertising panes. Advertisements are then sold based in part on a percentage of on-screen display space they occupy.

    摘要翻译: 一种用于根据广告消耗在用户显示器上显示的分页上的相对页面百分比来销售屏幕上广告的方法。 本发明包括基于“眼球空间”和放置的用于屏幕上广告的支付模型。 在一个实施例中,具有广告窗格的分页适应性页面被创作,并且创建适应性广告以适合广告窗格。 然后广告部分地基于它们占据的屏幕显示空间的百分比来出售。

    E-plane filter and a method of forming an E-plane filter
    76.
    发明授权
    E-plane filter and a method of forming an E-plane filter 有权
    E平面滤波器和形成E平面滤波器的方法

    公开(公告)号:US06876277B2

    公开(公告)日:2005-04-05

    申请号:US10325749

    申请日:2002-12-23

    申请人: Michael Cooper

    发明人: Michael Cooper

    IPC分类号: H01P1/207 H01P1/208 H01P11/00

    CPC分类号: H01P1/207

    摘要: An E-plane filter comprises a housing having a waveguide filter channel and a septum defining a plurality of couplers spaced apart along the length of the filter channel, thereby forming a resonator cavity between each adjacent coupler. The portion of the filter channel which accommodates the couplers and each resonator cavity is curved or otherwise changes direction in a plane transverse to the channel walls.

    摘要翻译: E平面滤波器包括具有波导滤波器通道的壳体和限定沿着滤波器通道的长度间隔开的多个耦合器的隔膜,从而在每个相邻耦合器之间形成谐振腔。 容纳耦合器和每个谐振器腔的滤波器通道的部分在横向于通道壁的平面中弯曲或以其它方式改变方向。