公开(公告)号：US20080058298A1

公开(公告)日：2008-03-06

申请号：US11894712

申请日：2007-08-20

申请人： Philip Beachy ,  Michael Cooper ,  Jeffrey Porter

发明人： Philip Beachy ,  Michael Cooper ,  Jeffrey Porter

IPC分类号： A61K31/438 ,  A61K31/435 ,  A61K31/58 ,  A61P21/00 ,  A61P25/00 ,  A61P35/00 ,  C12N5/00

CPC分类号： A61K31/4355 ,  A61K31/00 ,  A61K31/435 ,  A61K31/438 ,  A61K31/58

摘要： The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

摘要翻译： 本发明提供了抑制由刺猬蛋白产生的旁分泌和/或自分泌信号的测定和试剂，例如涉及使用甾族生物碱或其他小分子的刺猬蛋白信号转导途径的异常活化。

公开(公告)号：US20060142245A1

公开(公告)日：2006-06-29

申请号：US11270984

申请日：2005-11-11

申请人： Philip Beachy ,  Michael Cooper ,  Jeffery Porter

发明人： Philip Beachy ,  Michael Cooper ,  Jeffery Porter

IPC分类号： A61K31/695 ,  A61K31/66 ,  A61K31/56

CPC分类号： A61K31/4355 ,  A61K31/00 ,  A61K31/435 ,  A61K31/438 ,  A61K31/58

摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。

公开(公告)号：US20070053883A1

公开(公告)日：2007-03-08

申请号：US10550220

申请日：2004-03-24

申请人： Philip Beachy ,  Michael Cooper

发明人： Philip Beachy ,  Michael Cooper

IPC分类号： A61K35/30 ,  A61K38/17 ,  A61K31/724 ,  C12N5/08

CPC分类号： A61K35/30 ,  C12N5/0619 ,  C12N2500/36 ,  C12N2501/41 ,  C12N2501/90

摘要： Methods are provided in which a sterol-depleting agent such as β-cyclodextrin (βCD), is used to modulate signaling by a differentiation signaling protein such as Hedgehog protein or a BMP in vitro. As illustrated herein, the use of βCD in conjunction with Sonic Hedgehog N-terminal peptide (ShhN) causes substantially all of the cells in neural plate explants to differentiate as neurons, such as motor neurons. Also provided are cell therapy methods and screening methods that rely on the modulation of signaling of a differentiation signaling protein such as Hedgehog, by a sterol-depleting agent such as βCD.

摘要翻译： 提供了其中使用甾体消耗剂如β-环糊精（βCD）来调节由分化信号蛋白如Hedgehog蛋白或BMP在体外的信号转导的方法。 如本文所示，βCD与Sonic Hedgehog N末端肽（ShhN）结合使用导致神经平板外植体中的所有细胞基本上分化为神经元，例如运动神经元。 还提供了依赖于诸如Hedgehog的分化信号蛋白的信号调节的细胞治疗方法和筛选方法，其通过消耗甾烷醇的消耗剂如βCD。

公开(公告)号：US08610743B2

公开(公告)日：2013-12-17

申请号：US13174358

申请日：2011-06-30

申请人： Ricky Poston ,  Michael Cooper ,  Ting He ,  Scott Sellers

发明人： Ricky Poston ,  Michael Cooper ,  Ting He ,  Scott Sellers

IPC分类号： G09G5/00

CPC分类号： G06F3/0481 ,  G06F3/04815 ,  G06F2203/04805 ,  G06T19/003 ,  G06T2200/24

摘要： A computer program product is tangibly embodied on a computer-readable medium and includes executable code that, when executed, is configured to cause a data processing apparatus to display multiple objects in a three dimensional (3D) representation, where the multiple objects are visual representations of real objects, and display a subset of the objects and associated metadata in a shaped lens that is movable within the 3D representation in all three axes, where the subset of the objects displayed within the shaped lens are sized larger than the objects outside of the shaped lens.

摘要翻译： 计算机程序产品被有形地体现在计算机可读介质上并且包括可执行代码，所述可执行代码在被执行时被配置为使数据处理设备在三维（3D）表示中显示多个对象，其中所述多个对象是视觉表示 并且在所有三个轴中在3D表示内可移动的成形透镜中显示对象和相关元数据的子集，其中显示在成形透镜内的对象的子集的尺寸大于 形状的镜片。

公开(公告)号：US08180897B2

公开(公告)日：2012-05-15

申请号：US10889158

申请日：2004-07-12

申请人： Geoffrey S. Barrall ,  Trevor Willis ,  Simon Benham ,  Michael Cooper ,  Jonathan Meyer ,  Christopher J. Aston ,  John Winfield

发明人： Geoffrey S. Barrall ,  Trevor Willis ,  Simon Benham ,  Michael Cooper ,  Jonathan Meyer ,  Christopher J. Aston ,  John Winfield

IPC分类号： G06F15/16

CPC分类号： H04L29/06 ,  G06F17/30203 ,  H04L67/00 ,  H04L67/42 ,  H04L69/08 ,  H04L69/12 ,  H04L69/329

摘要： An apparatus in one embodiment handles service requests over a network, wherein the network utilizes a protocol. In this aspect, the apparatus includes: a network subsystem for receiving and transmitting network service requests using the network protocol; and a service subsystem, coupled to the network subsystem, for satisfying the network service requests. At least one of the network subsystem and the service subsystem is hardware-implemented; the other of the network subsystem and the service subsystem may optionally be hardware-accelerated. A variety of related embodiments are also provided, including file servers and web servers.

摘要翻译： 一个实施例中的装置通过网络处理服务请求，其中网络利用协议。 在这方面，该装置包括：网络子系统，用于使用网络协议接收和发送网络服务请求; 以及耦合到网络子系统的用于满足网络服务请求的服务子系统。 网络子系统和服务子系统中的至少一个是硬件实现的; 网络子系统和服务子系统中的另一个可以可选地被硬件加速。 还提供了各种相关实施例，包括文件服务器和web服务器。

公开(公告)号：US08028115B2

公开(公告)日：2011-09-27

申请号：US12535402

申请日：2009-08-04

申请人： Geoffrey S. Barrall ,  Trevor E. Willis ,  Simon L. Benham ,  Michael Cooper ,  Jonathan Meyer ,  Christopher J. Aston ,  John Winfield

发明人： Geoffrey S. Barrall ,  Trevor E. Willis ,  Simon L. Benham ,  Michael Cooper ,  Jonathan Meyer ,  Christopher J. Aston ,  John Winfield

IPC分类号： H05K7/10

CPC分类号： H04L29/06 ,  G06F17/30203 ,  H04L67/00 ,  H04L67/42 ,  H04L69/08 ,  H04L69/12 ,  H04L69/329

摘要： A file system adapter card that may be plugged into a host computer system for providing hardware-based file system accesses outside the purview of a host operating system running on the host computer system. The file system adapter card includes a hardware-implemented or hardware-accelerated file service subsystem and a computer bus that permits a host computer system to communicate directly with the file service subsystem for providing file service requests and receiving file service responses. The file service subsystem includes dedicated hardware that operates outside the immediate control of a host operating system, including specialized circuitry for performing at least one major subsystem function.

摘要翻译： 可插入到主计算机系统中的文件系统适配器卡，用于在主计算机系统上运行的主机操作系统的权限之外提供基于硬件的文件系统访问。 文件系统适配器卡包括硬件实现的或硬件加速的文件服务子系统和允许主计算机系统直接与文件服务子系统进行通信的计算机总线，用于提供文件服务请求和接收文件服务响应。 文件服务子系统包括在主机操作系统的即时控制之外操作的专用硬件，包括用于执行至少一个主要子系统功能的专用电路。

公开(公告)号：US20080081367A1

公开(公告)日：2008-04-03

申请号：US11868093

申请日：2007-10-05

申请人： Samuel Sowemimo-Coker ,  Marcus Scott ,  Marc Long ,  Ed Margerrison ,  Michael Cooper

发明人： Samuel Sowemimo-Coker ,  Marcus Scott ,  Marc Long ,  Ed Margerrison ,  Michael Cooper

IPC分类号： C12N5/06

CPC分类号： A61K35/17 ,  A61K35/15 ,  A61K35/19 ,  A61K35/28 ,  A61K35/32 ,  A61K35/35 ,  A61L27/3616 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/3895 ,  A61L2430/02 ,  C12M47/02 ,  C12N5/0087 ,  C12N5/0634 ,  C12N5/0644

摘要： The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

公开(公告)号：US20070271247A1

公开(公告)日：2007-11-22

申请号：US11828084

申请日：2007-07-25

申请人： Steven Best ,  Michael Brown ,  Michael Cooper

发明人： Steven Best ,  Michael Brown ,  Michael Cooper

IPC分类号： G06F17/30

CPC分类号： G06Q30/0623 ,  G06F17/30867

摘要： Personalized searching including providing in a search portal a personal search term list; receiving from a user a navigation identification message; and inserting index records in a personalized search index. Inserting index records in a personalized search index typically comprises retrieving a document from a navigation location and indexing the navigation location and keywords from the personal search term list that occur in the retrieved document. A navigation identification message may comprise a search keyword and inserting index records in a personalized search index may include indexing the search keyword with the navigation location in the personalized search index. Embodiments typically include creating and transmitting to users, in dependence upon the personalized search index, search criteria, and user identification, responses to search query messages.

摘要翻译： 个性化搜索，包括在搜索门户中提供个人搜索词列表; 从用户接收导航标识消息; 并将索引记录插入到个性化搜索索引中。 在个性化搜索索引中插入索引记录通常包括从导航位置检索文档并且从检索到的文档中出现的个人搜索词列表中索引导航位置和关键词。 导航识别消息可以包括搜索关键字，并且在个性化搜索索引中插入索引记录可以包括将搜索关键字与个性化搜索索引中的导航位置进行索引。 实施例通常包括根据个性化搜索索引，搜索条件和用户标识，向用户创建和发送对搜索查询消息的响应。

公开(公告)号：US20070114105A1

公开(公告)日：2007-05-24

申请号：US11433928

申请日：2006-05-15

申请人： Leigh Fraser ,  Neil McNab ,  Paul Rouse ,  Peter Riemer ,  James Lethbridge ,  Michael Cooper ,  David Harries ,  Melvin Dyke

发明人： Leigh Fraser ,  Neil McNab ,  Paul Rouse ,  Peter Riemer ,  James Lethbridge ,  Michael Cooper ,  David Harries ,  Melvin Dyke

IPC分类号： F16D25/00

CPC分类号： F16D48/0206 ,  F16D2048/0212 ,  F16D2048/0221 ,  F16D2500/5114

摘要： A hydraulic clutch actuation system having a hydraulic clutch control device which includes at least one clutch master cylinder that communicates via a pressure-medium line with a clutch slave cylinder used for actuating a clutch device, the pressure prevailing in the pressure-medium line being relievable via at least one emergency release valve device to permit disengagement of the clutch device in an emergency situation. The hydraulic clutch actuation system is distinguished in that the emergency release valve device has a seal-carrier device for a sealing element which is movable in response to an electromagnet out of an open position, in which a pressure-medium inlet is open, into a closed position in which the sealing element seals the pressure-medium inlet.

摘要翻译： 一种具有液压离合器控制装置的液压离合器驱动系统，该液压离合器控制装置包括至少一个离合器主缸，所述至少一个离合器主缸经由压力介质管线与用于致动离合器装置的离合器从动缸连通，压力介质管线中的压力可以缓解 通过至少一个紧急释放阀装置，以在紧急情况下允许离合器装置脱离。 液压离合器致动系统的特征在于，紧急释放阀装置具有用于密封元件的密封载体装置，其可响应于电磁体在压力介质入口打开的打开位置而移动到 关闭位置，其中密封元件密封压力介质入口。

公开(公告)号：US20060017529A1

公开(公告)日：2006-01-26

申请号：US10894563

申请日：2004-07-20

申请人： Michael Cooper ,  Robert Leroux

发明人： Michael Cooper ,  Robert Leroux

IPC分类号： H01P3/08

CPC分类号： H01P3/088 ,  H05K1/0237 ,  H05K1/0272 ,  H05K3/4652 ,  H05K3/4697 ,  H05K2201/09536

摘要： An improved multi-layered integrated RF/IF circuit board has been disclosed. The board is fabricated beginning with a center layer of material. In a first preferred embodiment, the center layer is a rigid core material. In a second preferred embodiment, the center layer is a pliable non-conductive material. For every layer added to the upper surface of the stack-up structure of the board, a corresponding layer of the same material is added to the lower surface of the stack-up structure. Thus, during the lamination process, both the upper and lower surfaces are primarily soft, pliable non-conductive material. These non-conductive layers absorb any stresses introduced during the lamination process. Thus, when cooled, the board has large area flatness. Standard manufacturing processes can be used for each individual step in the fabrication of the board. Therefore, a multi-layered integrated RF/IF circuit board in accordance with the present invention can be fabricated inexpensively.

摘要翻译： 已经公开了改进的多层集成RF / IF电路板。 该电路板是以中心层材料制成的。 在第一优选实施例中，中心层是刚性芯材料。 在第二优选实施例中，中心层是柔韧的非导电材料。 对于添加到板的堆叠结构的上表面的每个层，将相同材料的相应层添加到叠层结构的下表面。 因此，在层压过程中，上表面和下表面都是柔软的，柔韧的非导电材料。 这些非导电层吸收层压过程中引入的任何应力。 因此，当冷​​却时，板具有大的面积平坦度。 标准制造工艺可用于板的制造中的每个单独步骤。 因此，可以廉价地制造根据本发明的多层集成RF / IF电路板。