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公开(公告)号：US5223266A
公开(公告)日：1993-06-29
申请号：US876734
申请日：1992-04-27
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The present invention is directed to an improvement in a delivery device, the device comprising a wall that surrounds an internal lumen or compartment which contains a beneficial agent or medicament formulation, an expandable driving member and an optional density member, and having an a exit means, and wherein the improvement comprises prehydrating the delivery device as a means for advancing the beginning or startup of agent delivery from the delivery system to give earlier release of beneficial agent to the environment of use. An embodiment of the invention concerns a fluid reservoir in contact with the expandable driving member to provide prehydration of the device.
摘要翻译： 本发明涉及递送装置的改进，该装置包括围绕包含有益剂或药物制剂的内腔或隔室的壁，可膨胀驱动构件和任选的密封构件，并且具有出口装置 ，并且其中所述改进包括将所述输送装置预水化为用于促进从所述递送系统开始或启动药剂递送的装置，以将有益药剂早期释放到使用环境。 本发明的一个实施例涉及一种与可膨胀驱动构件接触的流体储存器，以提供装置的预水化。
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公开(公告)号：US5609885A
公开(公告)日：1997-03-11
申请号：US387967
申请日：1995-02-10
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
摘要翻译： 本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件， 试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等 小于或等于初级和次级DSC峰的总合合面积的约30％。 本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于 超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。
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公开(公告)号：US5045082A
公开(公告)日：1991-09-03
申请号：US463109
申请日：1990-01-10
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.
摘要翻译： 本发明提供了一种长期分配装置，其包括用于短期和连续输送药剂的第一药剂递送装置，与能够长期和连续递送药剂的第二药剂递送装置保持在一起。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。 随后快速递送有益药剂，其次是持续和长期的药剂输送。 在优选实施例中，该装置包括（1）用于将药剂快速且连续地递送到使用环境的短期递送装置; 和（2）包括围绕并限定内腔的半透壁的长期递送装置; 用于扩张和占据体积增加的管腔中的一种装置; 内腔中的有益剂，为使用环境提供可分配的配方; 以及用于将有益剂递送到使用环境的装置中的装置。
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