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    Long-term delivery device with early startup
    1.
    发明授权
    Long-term delivery device with early startup 失效
    早期启动的长期配送装置

    公开(公告)号：US5368863A

    公开(公告)日：1994-11-29

    申请号：US6448

    申请日：1993-01-21

    申请人： James B. Eckenhoff ,  Terry L. Burkoth ,  John P. Carr ,  Jeremy C. Wright

    发明人： James B. Eckenhoff ,  Terry L. Burkoth ,  John P. Carr ,  Jeremy C. Wright

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24

    CPC分类号： A61K9/0068 ,  A61K9/0004

    摘要： The present invention is directed to an improvement in a delivery device, the device comprising a wall that surrounds an internal lumen or compartment which contains a beneficial agent or medicament formulation, an expandable driving member and an optional density member, and having an exit means, and wherein the improvement comprises prehydrating the delivery device as a means for advancing the beginning or startup of agent delivery from the delivery system to give earlier release of beneficial agent to the environment of use. An embodiment of the invention concerns a fluid reservoir in contact with the expandable driving member to provide prehydration of the device.

    摘要翻译： 本发明涉及一种输送装置的改进，该装置包括围绕包含有益剂或药物制剂的内腔或隔室的壁，可膨胀的驱动构件和任选的密封构件，并且具有出口装置， 并且其中所述改进包括将所述递送装置预水化，作为用于促进从所述递送系统开始或启动药剂递送的装置，以将有益药剂早期释放到使用环境中。 本发明的一个实施例涉及一种与可膨胀驱动构件接触的流体储存器，以提供装置的预水化。

    Long-term delivery device with early startup
    2.
    发明授权
    Long-term delivery device with early startup 失效
    早期启动的长期配送装置

    公开(公告)号：US5223266A

    公开(公告)日：1993-06-29

    申请号：US876734

    申请日：1992-04-27

    申请人： James B. Eckenhoff ,  Terry L. Burkoth ,  John P. Carr ,  Jeremy C. Wright

    发明人： James B. Eckenhoff ,  Terry L. Burkoth ,  John P. Carr ,  Jeremy C. Wright

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0068 ,  A61K9/0004

    摘要： The present invention is directed to an improvement in a delivery device, the device comprising a wall that surrounds an internal lumen or compartment which contains a beneficial agent or medicament formulation, an expandable driving member and an optional density member, and having an a exit means, and wherein the improvement comprises prehydrating the delivery device as a means for advancing the beginning or startup of agent delivery from the delivery system to give earlier release of beneficial agent to the environment of use. An embodiment of the invention concerns a fluid reservoir in contact with the expandable driving member to provide prehydration of the device.

    摘要翻译： 本发明涉及递送装置的改进，该装置包括围绕包含有益剂或药物制剂的内腔或隔室的壁，可膨胀驱动构件和任选的密封构件，并且具有出口装置 ，并且其中所述改进包括将所述输送装置预水化为用于促进从所述递送系统开始或启动药剂递送的装置，以将有益药剂早期释放到使用环境。 本发明的一个实施例涉及一种与可膨胀驱动构件接触的流体储存器，以提供装置的预水化。

    Long-term delivery device including hydrophobic loading dose
    3.
    发明授权
    Long-term delivery device including hydrophobic loading dose 失效
    长期输送装置，包括疏水加载剂

    公开(公告)号：US5227167A

    公开(公告)日：1993-07-13

    申请号：US842939

    申请日：1992-02-27

    申请人： John P. Carr ,  James B. Eckenhoff ,  Terry L. Burkoth

    发明人： John P. Carr ,  James B. Eckenhoff ,  Terry L. Burkoth

    IPC分类号： A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0004

    摘要： The invention provides a dispensing device comprising a loading dose (first agent delivery means) for short-term and continuous delivery of an agent having a high potency, retained together with a long-term dispensing device (second agent delivery means) capable of a long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent may be delivered to the environment of use over time. A rapid initial delivery of beneficial agent is followed by continuous and prolonged delivery of agent.

    摘要翻译： 本发明提供了一种分配装置，其包括用于短期和连续输送具有高效力的药剂的负荷剂量（第一药剂递送装置），其与能够长时间的长期分配装置（第二药剂递送装置）一起保持 - 连续递送代理。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂可随时间递送到使用环境中。 快速初始交付有益药剂之后是持续和长期的药剂输送。

    Controlled release dispenser comprising beneficial agent
    6.
    发明授权
    Controlled release dispenser comprising beneficial agent 失效
    控制释放分配器包括有益剂

    公开(公告)号：US5273752A

    公开(公告)日：1993-12-28

    申请号：US763393

    申请日：1991-09-19

    申请人： Atul D. Ayer ,  Terry L. Burkoth ,  Anthony L. Kuczynski ,  Joseph C. Deters

    发明人： Atul D. Ayer ,  Terry L. Burkoth ,  Anthony L. Kuczynski ,  Joseph C. Deters

    IPC分类号： A61K9/00 ,  A23K1/18

    CPC分类号： A61K9/0068 ,  A61K31/70 ,  A61K9/0004

    摘要： A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising a beneficial agent and a pharmaceutically acceptable hydrophilic carrier in the space, (3) an expandable hydrophilic driving member in the space, (4) a density member in the space, and (5) one exit passageway or a multiplicity of exit passageways in the housing for delivering the beneficial agent from the dispenser, the diameter of each exit passageway being of a size to maximize release of the beneficial agent by osmotic pumping and to minimize release of the beneficial agent by diffusion or erosion to substantially avoid mechanical agitation-dependent release of the beneficial agent.

    摘要翻译： 公开了一种分配器，用于以速率控制的方式将亲水载体制剂中的有益剂递送给动物。 所述分配器包括（1）限定内部空间的半透明壳体，（2）至少一种组合物，其包含所述空间中的有益剂和药学上可接受的亲水载体，（3）所述空间中的可膨胀亲水性驱动构件，（4） 空间中的密度构件，以及（5）壳体中的一个出口通道或多个出口通道，用于从分配器输送有益物质，每个出口通道的直径具有使得有益剂释放最大化的大小 渗透泵送并且通过扩散或侵蚀来最小化有益剂的释放，以基本上避免有益剂的机械搅动依赖性释放。