公开(公告)号：US11320366B2

公开(公告)日：2022-05-03

申请号：US16219030

申请日：2018-12-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezer ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

IPC: B01L9/00 ,  G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10 ,  B01L7/00

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US11156801B2

公开(公告)日：2021-10-26

申请号：US16360257

申请日：2019-03-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  D. T. Le ,  Aaron Leimkuehler ,  George Sigal ,  Leo Tabakin ,  Jon Willoughby

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20210109100A1

公开(公告)日：2021-04-15

申请号：US16937500

申请日：2020-07-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: G01N33/573 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/58 ,  G01N21/76 ,  G01N33/53

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

公开(公告)号：US20210060567A1

公开(公告)日：2021-03-04

申请号：US17032524

申请日：2020-09-25

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

IPC: B01L7/00 ,  B01L3/00

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20210033523A1

公开(公告)日：2021-02-04

申请号：US16996418

申请日：2020-08-18

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

IPC: G01N21/25 ,  B01L3/00 ,  G01N21/66 ,  G01N21/76 ,  B01L9/00

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adopted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20200011866A1

公开(公告)日：2020-01-09

申请号：US16555271

申请日：2019-08-29

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/569 ,  G01N33/68 ,  G01N33/566

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US10241112B2

公开(公告)日：2019-03-26

申请号：US14285086

申请日：2014-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/569 ,  G01N33/543 ,  G01N33/566

Abstract: The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.

公开(公告)号：US20170362668A1

公开(公告)日：2017-12-21

申请号：US15696953

申请日：2017-09-06

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  George Sigal

IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/542 ,  G01N33/543

CPC classification number: C12Q1/70 ,  C12Q1/6813 ,  C12Q1/6834 ,  G01N33/542 ,  G01N33/54333 ,  C12Q2563/179

Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

公开(公告)号：US09777338B2

公开(公告)日：2017-10-03

申请号：US14357653

申请日：2012-11-09

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  George Sigal

IPC: G01N33/542 ,  C12Q1/70 ,  C12Q1/68 ,  G01N33/543

CPC classification number: C12Q1/70 ,  C12Q1/6813 ,  C12Q1/6834 ,  G01N33/542 ,  G01N33/54333 ,  C12Q2563/179

Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

公开(公告)号：US09618510B2

公开(公告)日：2017-04-11

申请号：US14206284

申请日：2014-03-12

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/569 ,  G01N33/533 ,  G01N33/543 ,  G01N33/53 ,  C12Q1/68

CPC classification number: G01N33/54393 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/56988 ,  G01N33/582 ,  G01N2021/7786 ,  C12Q2537/125 ,  C12Q2563/179

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.