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公开(公告)号：US10436784B2
公开(公告)日：2019-10-08
申请号：US14854514
申请日：2015-09-15
申请人： Meso Scale Technologies, LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/53 , G01N33/569 , G01N33/68 , G01N33/566
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20180246100A1
公开(公告)日：2018-08-30
申请号：US15902597
申请日：2018-02-22
申请人： Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/569 , G01N33/566 , G01N33/68
CPC分类号： G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US11600373B2
公开(公告)日：2023-03-07
申请号：US16555271
申请日：2019-08-29
申请人： MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/566 , G01N33/569 , G01N33/68 , G16H20/40 , G01T1/02 , G01T1/00 , G01N27/327 , G01N35/00
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20140315742A1
公开(公告)日：2014-10-23
申请号：US14348275
申请日：2012-09-28
申请人： MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/566
CPC分类号： G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
摘要翻译： 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。
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公开(公告)号：US11967410B2
公开(公告)日：2024-04-23
申请号：US15902597
申请日：2018-02-22
申请人： Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
CPC分类号： G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
摘要： Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20200011866A1
公开(公告)日：2020-01-09
申请号：US16555271
申请日：2019-08-29
申请人： MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/569 , G01N33/68 , G01N33/566
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20160003822A1
公开(公告)日：2016-01-07
申请号：US14854514
申请日：2015-09-15
申请人： Meso Scale Technologies, LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
摘要翻译： 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。
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公开(公告)号：USRE49774E1
公开(公告)日：2024-01-02
申请号：US17173898
申请日：2021-02-11
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/543 , G01N33/68
CPC分类号： B01L3/50853 , C12Q1/6804 , C12Q1/6816 , C12Q1/6876 , G01N33/54306 , G01N33/54353 , G01N33/6845 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0829 , G01N2458/10 , C12Q1/6816 , C12Q2563/131
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US11148145B2
公开(公告)日：2021-10-19
申请号：US16210165
申请日：2018-12-05
发明人： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6816 , C12Q1/6804 , G01N33/68
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20190178787A1
公开(公告)日：2019-06-13
申请号：US16219030
申请日：2018-12-13
发明人： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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