摘要:
Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as antimicrobial agents.
摘要:
A method and apparatus for forming a covered endoprosthesis employs a conformed polymeric coating about an expandable stent. The expandable stent has an open tubular construction. A first polymeric liner is positioned about an inner surface of the tubular stent and a second polymeric liner is positioned about an outer surface of the tubular stent. The first and second polymeric liners are conformed to the tubular stent and laminated together through the open construction of the stent at a location coextensive with the inner surface of the tubular stent.
摘要:
Various methods and apparatuses for correcting an animal to heel. Generally, the present disclosure teaches an animal training apparatus for correcting an animal to heel. The animal training apparatus includes a collar adapted to operably engaged with an animal, a stimulus unit operably engaged with the collar, and a control unit operably engaged with the collar and operatively connected with the stimulus unit, wherein the control unit is adapted to operably engage with a leash cord. The animal training apparatus also includes a tension measuring device of the control unit operably engaged with the collar and adapted for measuring tension in the leash cord and producing an electrical signal when the tension exceeds a predetermined tension threshold; wherein the control unit is selectively programmable to generate at least one correction stimulus to the animal when the animal exceeds the predetermined tension threshold set in the control unit.
摘要:
An example antimicrobial treatment system includes an illumination system configured to deliver illumination that activates a photosensitizing agent applied to a cornea. The system also includes a controller configured to control the illumination system. The controller detects an ulcerative region on a cornea and causes the illumination system to deliver the illumination to activate the photosensitizing agent applied to the ulcerative region according to a set of parameters for treating the ulcerative region. The illumination is restricted to the ulcerative region, and activation of the photosensitizing agent in the ulcerative region generates an antimicrobial effect.
摘要:
Chimeric ErbB ligand binding molecules having detectable binding activity for more ErbB ligands than any one of native ErbB 1, ErbB3 or ErbB4 are disclosed. Preferably, the binding molecules bind a broad spectrum and, more preferably, the full spectrum of ErbB ligands. The chimeric ErbB ligand binding molecules generally have a subunit LI derived from one of ErbB1, 3, or 4 and a subunit LII derived from another distinct ErbB receptor type. The sub-domain, SI, which joins LI and LII can be from either one of the receptor types or can have portions from both. Pharmaceutical compositions that contain the molecules and methods for the treatment of ErbB sensitive diseases are also disclosed.
摘要:
An annuloplasty device includes a plurality of corkscrew anchors. The annuloplasty device further includes a core wire extending along the length of the device and at least one corkscrew wire which is operably connected to the corkscrew anchors to screw the corkscrew anchors into heart tissue. One or more of the corkscrew wires can include a drive key; the corkscrew anchors are connected to a sleeve with a keyway that engages the drive key on the corkscrew wires.
摘要:
A positioning device and method of using are provided herein. The positioning device includes an expandable cage through which blood can flow. The expandable cage is insertable into a bodily organ, for example a heart, and expanded to temporarily secure the positioning device within the organ. Then, the cage can be used to steady the implantation of an annuloplasty device, for example. Alternatively, the expanded cage can be used to locate a desired area or feature of the body organ in which it is inserted by way of fluoroscopy.
摘要:
A stent assembly includes a stent, a covering on at least a portion of the stent, and a string encircling at least a portion of the covering. The string is releasably engaged to the covering or stent or both the covering and the stent. The string can be adhered to the stent, or the stent assembly, to the covering of the stent assembly, or both the covering and the stent. The string can be wrapped around the stent or covering in an interwoven loop or knit pattern. The covering can be made to overlap a perforation in a body lumen such as an artery or blood vessel and prevent bleeding.