公开(公告)号：US09814872B2

公开(公告)日：2017-11-14

申请号：US14113393

申请日：2012-04-26

申请人： Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

发明人： Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC分类号： A61M5/19 ,  A61M39/22 ,  A61M5/24 ,  A61M5/31

CPC分类号： A61M39/22 ,  A61M5/19 ,  A61M5/24 ,  A61M5/3134 ,  A61M2005/3128

摘要： The invention faces the technical problem of reducing the uncertainty over exact doses ejected from a medical device and at the same time providing a homogeneous, but controlled mixture of at least two fluids while a simple production should be maintained. A medical device comprising a first valve, a second valve, a first pre-valve ullage, a second pre-valve ullage, a post-valve ullage with a first end and a second end and a needle is presented. The first pre-valve ullage is connected to the post-valve ullage by the first valve and the second pre-valve ullage is connected to the post-valve ullage by the second valve. A first fluid is guidable from the first pre-valve ullage to the post-valve ullage and a second fluid is guidable from the second pre-valve ullage to the post-valve ullage.

公开(公告)号：US09717863B2

公开(公告)日：2017-08-01

申请号：US14113392

申请日：2012-04-26

申请人： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

发明人： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC分类号： A61M5/50 ,  A61M5/34 ,  A61M5/31

CPC分类号： A61M5/50 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/31593 ,  A61M5/3202 ,  A61M5/3286 ,  A61M5/34 ,  A61M5/347 ,  A61M2005/3118 ,  A61M2005/3128 ,  A61M2205/50 ,  A61M2205/502

摘要： The invention is related to an apparatus comprising a dispense interface comprising a lockout element for use with a drug delivery device, the lockout element comprising at least one spring component removeably maintained in a respective first position such that when the dispense interface is first attached and then removed from said drug delivery device, each spring component moves into a respective second position, which respective second position is configured to prevent said dispense interface from being reattached to a drug delivery device.

公开(公告)号：USD759572S1

公开(公告)日：2016-06-21

申请号：US29519138

申请日：2015-03-02

申请人： David Moore

设计人： David Moore

公开(公告)号：US20150314082A1

公开(公告)日：2015-11-05

申请号：US14113535

申请日：2012-04-26

申请人： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

发明人： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC分类号： A61M5/50 ,  A61M5/34

CPC分类号： A61M5/50 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/34 ,  A61M2205/273

摘要： The invention relates to a dispense interface for use with a drug delivery device with an inner body and with a lockout element, wherein the lockout element is coupled to the inner body, wherein the lockout element is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface is attachable to the drug delivery device, wherein in the locked condition the dispense interface is not-attachable to the drug delivery device and wherein the lockout element is configured to move from the receptive condition to the locked condition when said dispense interface is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface according to the invention and with a drug delivery device, wherein the dispense interface is removably attached to the drug delivery device.

摘要翻译： 本发明涉及一种用于具有内部主体和具有锁定元件的药物输送装置的分配界面，其中锁定元件联接到内部主体，其中锁定元件可从接受状态移动到锁定状态， 其中在所述接收状态下，所述分配界面可附接到所述药物输送装置，其中在所述锁定状态下，所述分配界面不能附着于所述药物输送装置，并且其中所述锁定元件构造成从所述接受状态移动到所述锁定状态 当所述分配界面附接到所述药物递送装置并从其分离时。 本发明解决了在已经与药物递送装置一起使用之后降低分配界面的再利用风险的技术问题。 本发明还涉及具有根据本发明的分配界面和药物递送装置的装置，其中分配界面可移除地附接到药物递送装置。

公开(公告)号：US20140142512A1

公开(公告)日：2014-05-22

申请号：US14130032

申请日：2012-07-12

申请人： Joseph Butler ,  David Moore ,  Paul Richard Draper ,  Stephen Francis Gilmore

发明人： Joseph Butler ,  David Moore ,  Paul Richard Draper ,  Stephen Francis Gilmore

IPC分类号： A61M5/315

CPC分类号： A61M5/31551 ,  A61M5/31525 ,  A61M5/31541 ,  A61M5/31585 ,  A61M5/31593 ,  A61M5/31595 ,  A61M2005/2488 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2205/52 ,  G01D5/2497 ,  G01D5/25

摘要： A drug delivery device is presented comprising of a housing, a plurality of contacts, and a cylindrical member configured to be rotatably supported inside the housing, wherein the outer surface of the cylindrical member is provided with a plurality of tracks together forming an encoder, each track comprising conductive segments and non-conductive segments, and wherein the cylindrical member is supported in the housing such that each track is engaged by a respective one of the plurality of contacts.

摘要翻译： 本发明提供了一种药物输送装置，其包括壳体，多个触点和构造成可旋转地支撑在壳体内的圆柱形构件，其中圆柱形构件的外表面设置有多个轨道，一起形成编码器，每个轨道各自形成编码器 轨道，其包括导电段和非导电段，并且其中所述圆柱形构件被支撑在所述壳体中，使得每个轨道由所述多个触点中的相应一个接合。

公开(公告)号：US20140066879A1

公开(公告)日：2014-03-06

申请号：US14112453

申请日：2012-04-26

申请人： Marc Holtwick ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

发明人： Marc Holtwick ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC分类号： A61M5/32

CPC分类号： A61J1/2093 ,  H01R12/724 ,  H01R13/502 ,  H01R13/6658

摘要： The invention is related to an apparatus comprising an inner body of a dispense interface and a manifold, wherein the inner body comprises a recess configured to receive a distal needle from a distal end of the inner body, a first fluid reservoir and a second fluid reservoir, and wherein the manifold comprises a filling block configured to redirect flow, a fluid groove arrangement configured to provide a fluid connection to the filling block, wherein the inner body and the manifold are assembled such that there is formed a channel providing a fluid connection from the first fluid reservoir and the second fluid reservoir, respectively, via the fluid groove arrangement and the filling block to the recess. The invention is further related to a drug delivery device comprising an apparatus of the aforementioned kind

摘要翻译： 本发明涉及包括分配界面和歧管的内部主体的装置，其中，所述内部主体包括被配置为从所述内部主体的远端接收远侧针的凹部，第一流体容器和第二流体容器 ，并且其中所述歧管包括被配置为重定向流的填充块，构造成提供到所述填充块的流体连接的流体槽布置，其中所述内主体和所述歧管被组装成使得形成通道， 第一流体储存器和第二流体储存器分别经由流体槽布置和填充块到达凹部。 本发明进一步涉及包括上述类型的装置的药物递送装置

公开(公告)号：US20140052077A1

公开(公告)日：2014-02-20

申请号：US14113987

申请日：2012-04-26

申请人： Marc Holtwick ,  Jeffrey Zajac ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

发明人： Marc Holtwick ,  Jeffrey Zajac ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC分类号： A61M5/34

CPC分类号： A61M5/349 ,  A61M5/158 ,  A61M5/34 ,  A61M5/343

摘要： The invention faces the technical problem of providing a tight connection between a tube and an dispense interface, while at the same time the biocompatibility of the connection can be improved. The technical problem is solved by an apparatus comprising a tube configured to guide a medium and a dispense interface. The tube comprises a first opening and a second opening, while the dispense interface comprises a recess. The recess has a first opening and a second opening and the tube is at least in part inserted into the recess. The tube is permanently affixed to the dispense interface by a combination of an interference fit and an adhesive, such that the interference fit prevents the adhesive from contaminating the medium.

摘要翻译： 本发明面临着在管和分配界面之间提供紧密连接的技术问题，同时可以提高连接的生物相容性。 该技术问题通过包括配置成引导介质和分配界面的管的装置来解决。 管包括第一开口和第二开口，而分配界面包括凹部。 凹部具有第一开口和第二开口，并且管至少部分地插入凹部中。 通过过盈配合和粘合剂的组合将管永久地固定到分配界面，使得过盈配合防止粘合剂污染介质。

公开(公告)号：US20130226081A1

公开(公告)日：2013-08-29

申请号：US13883190

申请日：2011-10-31

申请人： James Alexander Davies ,  David Moore

发明人： James Alexander Davies ,  David Moore

IPC分类号： A61M5/315

CPC分类号： A61M5/283 ,  A61M5/2033 ,  A61M5/2066 ,  A61M5/2425 ,  A61M5/2448 ,  A61M5/2466 ,  A61M5/31596 ,  A61M5/326 ,  A61M5/3294 ,  A61M2005/1787 ,  A61M2005/247 ,  A61M2005/31516 ,  A61M2005/3247 ,  A61M2005/3267

摘要： A medicated module attachable to a drug delivery device. The medicated module comprises a housing configured for attachment to a drug delivery device. The drug delivery device comprises a first medicament. A collapsible reservoir is contained within the housing. A pre-determined volume of a second medicament is contained within the reservoir. A needle arrangement is configured within the housing and the needle arrangement is arranged in fluid communication with the collapsible reservoir. A needle shroud may be configured, such that, during an injection step, the shroud acts on the reservoir to inject the second medicament.

摘要翻译： 可附接到药物输送装置的药物模块。 药物模块包括构造成附接到药物递送装置的壳体。 药物递送装置包括第一药物。 可拆卸的储存器容纳在壳体内。 第二药物的预定体积被包含在储存器内。 针布置配置在壳体内，并且针布置与可折叠储存器流体连通地布置。 可以配置针罩，使得在注射步骤期间，护罩作用在储存器上以注射第二药剂。

公开(公告)号：US20130204186A1

公开(公告)日：2013-08-08

申请号：US13636569

申请日：2011-03-23

申请人： David Moore ,  Garen Kouyoumjian ,  Christopher John Jones ,  James Mark Watson ,  John David Cross ,  Malcolm Stanley Boyd ,  Alasdair George Young ,  Naceur Rekaya

发明人： David Moore ,  Garen Kouyoumjian ,  Christopher John Jones ,  James Mark Watson ,  John David Cross ,  Malcolm Stanley Boyd ,  Alasdair George Young ,  Naceur Rekaya

IPC分类号： A61M5/32 ,  A61M5/50

CPC分类号： A61M5/2448 ,  A61M5/2466 ,  A61M5/31525 ,  A61M5/31533 ,  A61M5/3204 ,  A61M5/326 ,  A61M5/3272 ,  A61M5/3294 ,  A61M5/3297 ,  A61M5/347 ,  A61M5/5086 ,  A61M2005/1787 ,  A61M2005/3247 ,  A61M2005/3267 ,  A61M2205/583

摘要： A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir (22) when the needle guard (42) is retracted. The needle guard (42) prevents accidental needle sticks before and after an injection, and locks after dose delivery.

摘要翻译： 公开了一种用于共注射至少两种药物的注射系统的药物模块（4），其中包含主要药物的主要递送装置接受含有单剂量次级药物的药物组件（4），并且其中两种药物被递送 通过空心针（3）。 药物模块（4）不需要使用者手动接合含有辅助药剂的贮存器（22）。 相反，当针护罩（42）缩回时，偏置构件（48）自动启动储存器（22）。 针罩（42）防止注射前后的意外针刺，并在给药后锁定。

公开(公告)号：US08504876B2

公开(公告)日：2013-08-06

申请号：US12771263

申请日：2010-04-30

申请人： Peter Mork ,  Adriane Chapman ,  Ken Samuel ,  Irina Vayndiner ,  David Moore

发明人： Peter Mork ,  Adriane Chapman ,  Ken Samuel ,  Irina Vayndiner ,  David Moore

IPC分类号： G06F11/00

CPC分类号： G06F21/55 ,  G06F17/30442

摘要： Methods, systems and computer program products for detecting anomalies for a database system are provided. A method may include extracting workload features from a query optimizer based on a query workload and generating feature models for the extracted workload features. The method may also include extracting instance features from the query optimizer based on a query instance. Instance feature values may be obtained. The method may further include applying a query instance to the workload feature models to produce a prediction value for each workload feature. Anomalies may be reported based on a comparison of each instance feature value with a corresponding prediction value. A system for detecting anomalies for a database system may include a query optimizer, a feature modeler and an anomaly detector.

摘要翻译： 提供了用于检测数据库系统异常的方法，系统和计算机程序产品。 一种方法可以包括基于查询工作量从查询优化器提取工作负载特征，并为所提取的工作负载特征生成特征模型。 该方法还可以包括基于查询实例从查询优化器提取实例特征。 可以获得实例特征值。 该方法还可以包括将查询实例应用于工作负载特征模型以产生每个工作负载特征的预测值。 可以基于每个实例特征值与相应的预测值的比较来报告异常。 用于检测数据库系统的异常的系统可以包括查询优化器，特征建模器和异常检测器。