公开(公告)号：US08465533B2

公开(公告)日：2013-06-18

申请号：US12042830

申请日：2008-03-05

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N5/06

CPC分类号： A61B18/04 ,  A61N1/40 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

摘要： A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.

公开(公告)号：US08406870B2

公开(公告)日：2013-03-26

申请号：US13216865

申请日：2011-08-24

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/18

CPC分类号： A61N1/40 ,  A61K31/337 ,  A61K41/0052 ,  A61N1/326

摘要： Chemotherapeutic treatment for certain cancers may be combined with low intensity, intermediate frequency alternating electric fields that are tuned to a particular type of target cell. When the tuned fields were combined with Paclitaxel, Doxorubicin or Cyclophosphamide, excellent results were obtained against human breast cancer cells (MDA-MB-231) and non-small cell lung (H1299) carcinomas in culture. More specifically, cell proliferation inhibition similar to that obtained by drug alone was reached by exposure to the combined treatment at drug concentrations between one and two orders of magnitude lower than for drug-only regimens of treatment.

摘要翻译： 某些癌症的化学治疗可以与被调谐到特定类型的靶细胞的低强度中频交变电场组合。 当调谐场与紫杉醇，多柔比星或环磷酰胺组合时，获得针对培养物中的人乳腺癌细胞（MDA-MB-231）和非小细胞肺（H1299）癌的优异结果。 更具体地，与药物单独获得的细胞增殖抑制类似，通过暴露于药物浓度比药物治疗方案低1至2个数量级的组合治疗来达到。

公开(公告)号：US20120197128A1

公开(公告)日：2012-08-02

申请号：US13364851

申请日：2012-02-02

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61B8/00 ,  A61B8/02 ,  A61B5/08

CPC分类号： A61B8/02 ,  A61B5/0816 ,  A61B8/06 ,  A61B8/0883 ,  A61B8/488 ,  A61B8/5223 ,  A61B8/543

摘要： Operation of a patient's heart or lungs may be analyzed by transmitting ultrasound energy into the patient's lung, and detecting Doppler shifts of reflected ultrasound induced by moving borders between blood vessels/soft tissue in the lung and air filled alveoli that surround the blood vessels. Movement of the border is caused by pressure waves in the blood vessels that result in changes in diameter of those blood vessels. The detected Doppler shifts are processed with a noise reduction algorithm, and periodic features in the resulting data are then analyzed to determine the rate of the patient's heartbeat, the rate of the patient's breathing, and/or the appearance of anomalies in the patient's heartbeat

摘要翻译： 可以通过将超声能量发射到患者的肺中来检测患者心脏或肺的操作，并且通过在肺内的血管/软组织和围绕血管的空气填充的肺泡之间移动边界来检测反射超声波的多普勒频移。 边界运动是造成血管压力波，造成血管直径的变化。 检测到的多普勒频移用噪声降低算法进行处理，然后分析所得数据中的周期特征，以确定患者心跳的速率，患者呼吸的速率和/或患者心跳异常的出现

公开(公告)号：US20120184895A1

公开(公告)日：2012-07-19

申请号：US13428887

申请日：2012-03-23

申请人： Yoram Palti ,  Moshe Giladi

发明人： Yoram Palti ,  Moshe Giladi

IPC分类号： A61B18/00 ,  A61M37/00

CPC分类号： A61N1/326 ,  A61N1/40

摘要： Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

摘要翻译： 处于过程部分的电池容易受到具有特定频率和场强特性的交流电场的损害。 因此，快速分裂细胞的选择性破坏可以通过在目标区域中长时间施加AC电场来实现。 一些应用场地分割的细胞将被破坏，但不分裂的细胞不会受到伤害。 这有选择地损害快速分裂的细胞，如细菌，但不会伤害不分裂的正常细胞。 由于分割单元的脆弱性与分割单元的长轴与电场的力线之间的对准强烈相关，所以当场依次施加在不同的方向时，可以获得改进的结果。

公开(公告)号：US08175698B2

公开(公告)日：2012-05-08

申请号：US12146918

申请日：2008-06-26

申请人： Yoram Palti ,  Moshe Giladi

发明人： Yoram Palti ,  Moshe Giladi

IPC分类号： A61N1/32

CPC分类号： A61N1/326 ,  A61N1/40

摘要： Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

摘要翻译： 处于过程部分的电池容易受到具有特定频率和场强特性的交流电场的损害。 因此，快速分裂细胞的选择性破坏可以通过在目标区域中长时间施加AC电场来实现。 一些应用场地分割的细胞将被破坏，但不分裂的细胞不会受到伤害。 这有选择地损害快速分裂的细胞，如细菌，但不会伤害不分裂的正常细胞。 由于分割单元的脆弱性与分割单元的长轴与电场的力线之间的对准强烈相关，所以当场依次施加在不同的方向时，可以获得改进的结果。

公开(公告)号：US08170684B2

公开(公告)日：2012-05-01

申请号：US12729545

申请日：2010-03-23

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/40

CPC分类号： A61N1/0476 ,  A61N1/0408 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/046 ,  A61N1/0492

摘要： As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

摘要翻译： 与常规电极相比，本文所公开的电极构造在使患者的身体长时间放置时能够使对皮肤的刺激和损伤最小化。 电极由涂覆有薄介电材料的导电基底形成，并且多个开放空间通过电极。 这些开放空间是分布和大小的，以便当电极与患者身体接触时允许患者身体表面上的水分逸出。 电极的一个预期用途是通过在长时间内施加具有特定频率和场强特性的AC电场来治疗肿瘤。

公开(公告)号：US20120101381A1

公开(公告)日：2012-04-26

申请号：US13276463

申请日：2011-10-19

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61B8/04

CPC分类号： A61B6/06 ,  A61B6/02 ,  A61B8/04 ,  A61B8/488 ,  A61B8/5223 ,  A61B8/5269 ,  A61B8/5284

摘要： Operation of a patient's heart or lungs may be analyzed by transmitting ultrasound energy into the patient's lung, and detecting Doppler shifts of reflected ultrasound induced by moving borders between blood vessels in the lung and air filled alveoli that surround the blood vessels. Movement of the border is caused by pressure waves in the blood vessels that result in changes in diameter of those blood vessels. The detected Doppler shifts are used to obtain power and velocity data at each of a plurality of different air pressure levels, and the pulmonary blood pressure of the patient is then estimated based on the obtained data.

摘要翻译： 可以通过将超声能量传输到患者的肺中来检测患者心脏或肺的操作，并且通过在肺内的血管和围绕血管的空气填充的肺泡之间移动边界来检测反射超声波的多普勒频移。 边界运动是造成血管压力波，造成血管直径的变化。 所检测的多普勒频移用于在多个不同气压水平的每一个处获得功率和速度数据，然后基于获得的数据来估计患者的肺血压。

公开(公告)号：US20110137229A1

公开(公告)日：2011-06-09

申请号：US12958623

申请日：2010-12-02

申请人： Yoram Palti ,  Moshe Giladi

发明人： Yoram Palti ,  Moshe Giladi

IPC分类号： A61M37/00

CPC分类号： A61N1/205 ,  A61B18/04 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/32 ,  A61N1/326 ,  A61N1/40 ,  C12N13/00

摘要： Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time at particular frequencies with particular filed strengths. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

摘要翻译： 处于过程部分的电池容易受到具有特定频率和场强特性的交流电场的损害。 因此，快速分裂细胞的选择性破坏可以通过在特定场景强度的特定频率下在目标区域中延长的时间段内施加AC电场来实现。 一些应用场地分割的细胞将被破坏，但不分裂的细胞不会受到伤害。 这有选择地损害快速分裂的细胞，如细菌，但不会伤害不分裂的正常细胞。 由于分割单元的脆弱性与分割单元的长轴与电场的力线之间的对准强烈相关，所以当场依次施加在不同的方向时，可以获得改进的结果。

公开(公告)号：US07912540B2

公开(公告)日：2011-03-22

申请号：US11424141

申请日：2006-06-14

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/40

CPC分类号： A61N1/18 ,  A61N1/40

摘要： An article of clothing is provided for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected to one another by a cleavage furrow. The article of clothing includes insulated electrodes to be coupled to a generator for subjecting the living tissue to electric field conditions sufficient to cause movement of the polarizable intracellular members toward the cleavage furrow in response to a non-homogeneous electric field being induced in the dividing cells. The non-homogeneous electric field produces an increased density electric field in the region of the cleavage furrow. The movement of the polarizable intracellular intracellular members towards the cleavage furrow causes the breakdown thereof which adversely impacts the multiplication of the dividing cells.

摘要翻译： 提供了一种服装，用于选择性地破坏由分割细胞和非分裂细胞形成的活组织中的分裂细胞。 分裂细胞含有可极化的细胞内成员，并且在晚期后期或端粒酶期间，分裂细胞通过分裂沟相互连接。 该衣服包括要耦合到发生器的绝缘电极，用于使生物体组织响应于在分裂细胞中诱导的非均匀电场而使足够的可极化细胞内成员向分裂沟移动的电场条件 。 非均匀电场在分裂沟的区域产生增加的密度电场。 可极化细胞内细胞内成员向分裂沟的运动导致其破坏，这不利地影响分裂细胞的增殖。

公开(公告)号：US20100280385A1

公开(公告)日：2010-11-04

申请号：US12771091

申请日：2010-04-30

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61B8/06

CPC分类号： A61B8/06 ,  A61B8/488 ,  G01S7/52066 ,  G01S7/52071 ,  G01S7/52073 ,  G01S15/8979

摘要： A new approach to processing and displaying received Doppler signals is disclosed. This approach starts with a set of N power spectra corresponding to each of N times. Those power spectra are then used to create of set of pixels for display with respect to an X axis and a Y axis so that the X coordinate of each pixel in the set corresponds to a time and the Y coordinate of each pixel in the set corresponds to a quantized power level. An attribute (e.g., color or intensity) of each pixel in the set is set to represent the highest velocity for the time-and-quantized-power-level combination that corresponds to the X and Y coordinates of each pixel in the set.

摘要翻译： 公开了一种处理和显示接收的多普勒信号的新方法。 这种方法从对应于N次中的每一个的一组N个功率谱开始。 然后，这些功率谱用于创建相对于X轴和Y轴显示的像素组，使得组中每个像素的X坐标对应于时间，并且集合中的每个像素的Y坐标对应于 达到量化的功率水平。 将集合中的每个像素的属性（例如，颜色或强度）设置为表示对应于组中每个像素的X和Y坐标的时间和量化功率级组合的最高速度。