公开(公告)号：US07887833B2

公开(公告)日：2011-02-15

申请号：US10497705

申请日：2002-12-04

申请人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

发明人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

IPC分类号： A61K9/127 ,  C07C231/00 ,  C07C229/00

CPC分类号： C07D401/04 ,  A61K9/1272 ,  C07C219/06 ,  C07C233/36 ,  C07C235/28 ,  C07C237/10 ,  C07D303/46 ,  C07H7/00 ,  C07H15/10 ,  C07H15/26

摘要： An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

摘要翻译： 提供能够形成囊泡或脂质体的两亲化合物，所述两亲化合物具有至少一个含有选择性可切割基团或部分的头基，例如胆碱或苯丙氨酸衍生物的残基，以及至少一个位于所述 头组和/或其附近。 可切割基团或部分在选择性条件下被切割，包括化学，物理或生物环境的变化，并且优选在诸如脑或血液的生物环境中酶促切割。 由所述两亲性化合物制成的囊泡或脂质体适于将治疗物质或诊断剂特异性递送至靶器官或组织，或用于递送用于基因治疗的核酸。

公开(公告)号：US07677398B2

公开(公告)日：2010-03-16

申请号：US11574643

申请日：2005-09-04

申请人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

发明人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

IPC分类号： B01D39/00 ,  B01D39/14 ,  B01D71/28 ,  B01D67/00 ,  B05D5/00

CPC分类号： B01D67/0093 ,  B01D71/56 ,  B01D2323/38 ,  C02F1/441

摘要： The invention provides a process for improving the antifouling properties and for increasing the selectivity of commercial composite polyamide nanofiltration (NF) and reverse osmosis (RO) membranes comprising circulating a low concentration of water soluble monomers and an initiating redox couple in an aqueous solvent, without transverse pressure over the surface of the membrane thereby effecting a free-radical graft polymerization on the surface of the membrane.

摘要翻译： 本发明提供了一种改善防污性能和提高市售复合聚酰胺纳滤（NF）和反渗透（RO）膜的选择性的方法，其包括在水性溶剂中循环低浓度的水溶性单体和引发氧化还原对，而没有 在膜的表面上的横向压力，从而在膜的表面上实现自由基接枝聚合。

公开(公告)号：US20090011002A1

公开(公告)日：2009-01-08

申请号：US11813311

申请日：2006-01-02

申请人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

发明人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

IPC分类号： A61K9/127 ,  A61K9/14

CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1277

摘要： Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.

摘要翻译： 由包含至少一种无机化合物和/或金属的两亲物和核心的脂质层组成的纳米和中尺寸颗粒的制备方法，包括：（i）在普通溶剂中溶解至少一种自聚集的两亲物 与所述无机化合物或金属的至少一种无机，有机金属或金属有机前体; 和（ii）将所得溶液注入水溶液中或干燥所得溶液并对其进行再水化，以形成其中前体被两亲物包封并在其中转化为所述无机化合物的颗粒， /或金属固体形式。

公开(公告)号：US20080269417A1

公开(公告)日：2008-10-30

申请号：US11574643

申请日：2005-09-04

申请人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

发明人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

IPC分类号： C08F8/00 ,  C08G73/00

CPC分类号： B01D67/0093 ,  B01D71/56 ,  B01D2323/38 ,  C02F1/441

摘要： The invention provides a process for improving the antifouling properties and for increasing the selectivity of commercial composite polyamide nanofiltration (NF) and reverse osmosis (RO) membranes comprising circulating a low concentration of water soluble monomers and an initiating redox couple in an aqueous solvent, without transverse pressure over the surface of the membrane thereby effecting a free-radical graft polymerization on the surface of the membrane.

摘要翻译： 本发明提供了一种改善防污性能和提高市售复合聚酰胺纳滤（NF）和反渗透（RO）膜的选择性的方法，其包括在水性溶剂中循环低浓度的水溶性单体和引发氧化还原对，而没有 在膜的表面上的横向压力，从而在膜的表面上实现自由基接枝聚合。

公开(公告)号：US06755735B2

公开(公告)日：2004-06-29

申请号：US10199815

申请日：2002-07-19

申请人： Charles Linder ,  Robert A. Matousek

发明人： Charles Linder ,  Robert A. Matousek

IPC分类号： A01F1200

CPC分类号： A01D41/12

摘要： A one piece blow molded cover panel removably positionable in an access opening in a structure adjacent to a threshing region of an agricultural combine. The cover panel includes an inner wall, an outer wall generally co-extending with the inner wall in spaced relation thereto defining at least one cavity therebetween, and elongate upper and lower peripheral edge, and elongate spaced, side peripheral edges. A lower inner lip extends downwardly from the inner wall and the lower peripheral edge along substantially the length thereof, and an outer upper lip extends upwardly from the outer wall and the upper peripheral edge along substantially the length thereof, the cover panel having a size for insertion into the access opening in covering relation thereto with the lower inner lip in abutting relation to a lower edge of the structure defining a lower periphery of the opening and the outer upper lip in abutting relation to an upper edge of the structure defining an upper periphery of the opening, providing effective retaining, sealing, and enclosing functions.

摘要翻译： 一体式吹塑成型的盖板可移除地定位在与农业组合的脱粒区域相邻的结构中的进入开口中。 盖板包括内壁，外壁通常与内壁以间隔开的关系共同延伸，在其间限定至少一个空腔，以及细长的上下周边边缘和细长的间隔开的侧边缘。 一个下内唇缘从内壁和下周缘基本上沿其长度向下延伸，而外上唇沿其大致长度从外壁和上周边缘向上延伸，盖板的尺寸用于 插入进入开口中以与其相关的关系，其中下内唇与结构的下边缘抵接，该边缘限定开口的下周边，而外上唇与该结构的上边缘抵接，该上边缘限定上边缘 的开口，提供有效的保持，密封和封闭功能。

公开(公告)号：US4413999A

公开(公告)日：1983-11-08

申请号：US355260

申请日：1982-03-05

申请人： Charles Linder ,  Gershon Aviv

发明人： Charles Linder ,  Gershon Aviv

IPC分类号： C07D239/34 ,  C07D239/46 ,  C07D241/44 ,  C07D251/26 ,  C07D403/12 ,  C08F8/30 ,  C09B62/02 ,  C12N11/08

CPC分类号： C07D239/34 ,  C07D239/47 ,  C07D241/44 ,  C07D251/26 ,  C07D403/12 ,  C08F8/30 ,  C09B62/02 ,  C12N11/08

摘要： The invention provides amidoxime derivatives of the general formula ##STR1## wherein R.sub.1 is an alkyl group of 1 to 8 carbon atoms, phenyl, a heterocyclic ring structure of 5 to 8 atoms containing one or more nitrogen or oxygen atoms or combinations thereof or a bicyclic condensed ring system optionally containing at least one heterocyclic ring which groups may each be optionally substituted. R.sub.2 is a mono or bicyclic heterocyclic radical containing at least two nitrogen atoms which radical is also optionally substituted. R.sub.3 and R.sub.4 are independently H, or an alkyl of 1 to 4 carbon atoms or one, but not both, is ##STR2## and the other, H, wherein R.sub.5 or R.sub.6 are alkyls of 2 to 5 carbon atoms optionally substituted by R.sub.1, or a phenyl optionally substituted by R.sub.1 or R.sub.5 or R.sub.6 is combined with R.sub.1 to jointly form cyclic imidoximes or imidedioximes. The invention also provides processes for the preparation of these compounds and many uses therefor including application in affinity chromatography, enzyme reactors and for preparing dense and porous fibers, fabrics and particles.

摘要翻译： 本发明提供具有通式“IMAGE”的酰胺肟衍生物，其中R 1为1至8个碳原子的烷基，苯基，含有一个或多个氮原子或氧原子的其中5至8个原子的杂环结构或其组合或双环 任选地含有至少一个杂环的稠环系统，其各自可以任选被取代。 R2是含有至少两个氮原子的单或双环杂环基团，其基团也可任意取代。 R 3和R 4独立地是H或1至4个碳原子的烷基或一个但不是两个的烷基是，而另一个是H，其中R 5或R 6是任选被R 1取代的2至5个碳原子的烷基， 或任选被R 1或R 5或R 6取代的苯基与R 1组合以共同形成环状亚氨基肟或亚胺肟。 本发明还提供了这些化合物的制备方法及其许多用途，包括在亲和色谱法，酶反应器中的应用，以及用于制备致密和多孔纤维，织物和颗粒的方法。