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    PIPERIDINE AND PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF
    73.
    发明申请
    PIPERIDINE AND PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
    哌啶和哌嗪衍生物及其使用方法

    公开(公告)号：US20110245267A1

    公开(公告)日：2011-10-06

    申请号：US13139639

    申请日：2009-12-18

    申请人： Dong Xiao ,  Anandan Palani ,  Robert G. Aslanian

    发明人： Dong Xiao ,  Anandan Palani ,  Robert G. Aslanian

    IPC分类号： A61K31/497 ,  C07D513/04 ,  C07D417/14 ,  A61K31/437 ,  A61P11/00 ,  A61P1/00 ,  A61P25/00 ,  A61P3/10 ,  A61P3/08 ,  A61P3/04 ,  A61P3/00

    CPC分类号： C07D513/04

    摘要： The present invention relates to novel Piperidine and piperazine Derivatives, pharmaceutical compositions comprising the Piperidine and piperazine Derivatives and the use of these compounds of formula (I) for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

    摘要翻译： 本发明涉及新颖的哌啶和哌嗪衍生物，包含哌啶和哌嗪衍生物的药物组合物以及这些式（I）化合物用于治疗或预防治疗过敏，过敏引起的气道反应，充血，心血管疾病， 糖尿病，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。

    H.sub.3 receptor ligands of the phenyl-alkyl-imidazoles type
    77.
    发明授权
    H.sub.3 receptor ligands of the phenyl-alkyl-imidazoles type 失效
    苯基 - 烷基 - 咪唑型的H3受体配体

    公开(公告)号：US5990147A

    公开(公告)日：1999-11-23

    申请号：US186492

    申请日：1998-11-05

    申请人： Robert G. Aslanian

    发明人： Robert G. Aslanian

    IPC分类号： A61K31/4174 ,  C07D233/54 ,  C07D233/64 ,  A61K31/415

    CPC分类号： C07D233/64 ,  A61K31/4174

    摘要： Disclosed are novel phenyl-alkyl-imidazoles of the formula ##STR1## or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification.Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula I (or a salt or solvate thereof) to a patient in need of such treatment.Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula I in combination or admixture with a histamine H.sub.1 receptor antagonist.

    摘要翻译： 公开了下式的新型苯基 ​​- 烷基 - 咪唑或其药学上可接受的盐或溶剂合物，其中A和R如说明书中所定义。 还公开了治疗过敏，炎症，低血压，青光眼，睡眠障碍，胃肠道过度和低运动状态，中枢神经系统的低血压和多动症，阿尔茨海默病，精神分裂症，肥胖症和偏头痛的方法，包括给予有效量 的式I化合物（或其盐或溶剂合物）给予需要这种治疗的患者。 还公开了治疗上呼吸道过敏反应的方法，包括与组胺H1受体拮抗剂组合或混合施用式I化合物或其盐或溶剂合物。

    Bicyclic heterocyclic derivatives and methods of use thereof
    78.
    发明授权
    Bicyclic heterocyclic derivatives and methods of use thereof 失效
    双环杂环衍生物及其使用方法

    公开(公告)号：US08283360B2

    公开(公告)日：2012-10-09

    申请号：US13139656

    申请日：2009-12-18

    申请人： Anandan Palani ,  Ashwin U. Rao ,  Xiao Chen ,  Ning Shao ,  Ying R. Huang ,  Robert G. Aslanian

    发明人： Anandan Palani ,  Ashwin U. Rao ,  Xiao Chen ,  Ning Shao ,  Ying R. Huang ,  Robert G. Aslanian

    IPC分类号： A61K31/437 ,  C07D498/04

    CPC分类号： C07D513/04 ,  C07D498/04

    摘要： The present invention relates to novel Bicyclic Heterocyclic Derivatives, pharmaceutical compositions comprising the Bicyclic Heterocyclic Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

    摘要翻译： 本发明涉及新型双环杂环衍生物，包含双环杂环衍生物的药物组合物和这些化合物用于治疗或预防治疗过敏，过敏诱发的气道反应，充血，心血管疾病，炎性疾病，胃肠道疾病 糖尿病，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。